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Virus Gene/Protein ORF1a ORF1b ORF3a S E M N ORF7a ORF7b ORF8 ORF1ab ORF9b ORF10 ORF6 ORF9c

Disease COVID-19 Cell line Cystic Fibrosis Pediatric Multisystem Inflammatory Disease, COVID-19 related Thrombosis, COVID-19 related HIV Infections

Description Genotype/Subtype Immune Target gene Clinical data Treatment Location Sequence data

For highly variable viruses (e.g., HBV, HIV, SARS-CoV-2), ViMIC defaults to displaying mutations in a specific region. Click the green button to search for other regions, or click "Show All" to view all mutations (loading speed may be affected by network conditions).

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ORF1a

  

ORF1b

  

ORF3a

  

3CLpro

  

3'UTR

  

5'UTR

  

RBD

  

ORF7b-ORF8

  

upstream of N

  

Furin cleavage site

  

E

  

endoRNase

  

Exonuclease

  

S

  

NSP13

  

NSP3

  

M

  

Mpro

  

Methyltransferase

  

N

  

NSP14

  

NSP12

  

Non-coding region

  

NP

  

NS3

  

NS7a

  

NS7b

  

NS8

  

NSP5

  

NSP1

  

NSP10

  

NSP11

  

NSP15

  

NSP16

  

NSP2

  

NSP4

  

NSP6

  

NSP7

  

NSP8

  

NSP9

  

NTD

  

ORF8

  

ORF1ab

  

ORF9b

  

ORF10

  

ORF3

  

ORF6

  

ORF7a

  

ORF7b

  

ORF9

  

ORF9c

  

PLpro

  

RdRp

  

RBM

  

Replicase

  

RNA primase

  

• Mutation
• Sequence

ID	PMID	Mutation	Gene/Protein/Region	Encoding Gene/Protein	Disease	Description	Detail
1	40062859	A260V	3CLpro	ORF1a	Cell line	D	View
2	40062859	D515Y	3CLpro	ORF1a	Cell line		View
3	40062859	E166V	3CLpro	ORF1a	Cell line	D	View
4	40062859	F140A	3CLpro	ORF1a	Cell line	D	View
5	40062859	G1543T	3CLpro	ORF1a	Cell line		View
6	40062859	H172Y	3CLpro	ORF1a	Cell line	D	View
7	40062859	S144A	3CLpro	ORF1a	Cell line	D	View
8	40062859	T21I	3CLpro	ORF1a	Cell line	D	View
9	40062859	T688C	3CLpro	ORF1a	Cell line		View
10	40062859	T771A	3CLpro	ORF1a	Cell line		View
11	40062859	Y54A	3CLpro	ORF1a	Cell line	D	View
12	36689809	A193V	3CLpro	ORF1a	Cell line		View
13	36689809	A255V	3CLpro	ORF1a	Cell line		View
14	36689809	G15S	3CLpro	ORF1a	Cell line		View
15	36689809	H246Y	3CLpro	ORF1a	Cell line		View
16	36689809	K88R	3CLpro	ORF1a	Cell line		View
17	36689809	K90R	3CLpro	ORF1a	Cell line		View
18	36689809	L89F	3CLpro	ORF1a	Cell line		View
19	36689809	P108S	3CLpro	ORF1a	Cell line		View
20	36689809	P132H	3CLpro	ORF1a	Cell line		View
21	36689809	T21I	3CLpro	ORF1a	Cell line		View
22	36689809	T24I	3CLpro	ORF1a	Cell line		View
23	37243152	T21T	3CLpro	ORF1a	COVID-19	D G L	View
24	38004723	D216N	3CLpro	ORF1a		G R S C L	View
25	38004723	L232F	3CLpro	ORF1a		G R S C L	View
26	38004723	G15S	3CLpro	ORF1a		R S C L	View
27	37243152	M49I	3CLpro	ORF1a	COVID-19	D G L	View
28	37243152	M165K	3CLpro	ORF1a	COVID-19	D G L	View
29	37243152	M165M	3CLpro	ORF1a	COVID-19	D G L	View
30	37243152	M165R	3CLpro	ORF1a	COVID-19	D G L	View
31	37243152	M165T	3CLpro	ORF1a	COVID-19	D G L	View
32	37243152	D48D	3CLpro	ORF1a	COVID-19	D G L	View
33	37243152	D48H	3CLpro	ORF1a	COVID-19	D G L	View
34	37243152	D48N	3CLpro	ORF1a	COVID-19	D G L	View
35	37243152	D48Y	3CLpro	ORF1a	COVID-19	D G L	View
36	37243152	Q189K	3CLpro	ORF1a	COVID-19	D G L	View
37	37243152	Y54C	3CLpro	ORF1a	COVID-19	D G L	View
38	37243152	E166K	3CLpro	ORF1a	COVID-19	D G L	View
39	37243152	E166Q	3CLpro	ORF1a	COVID-19	D G L	View
40	37243152	F140I	3CLpro	ORF1a	COVID-19	D G L	View
41	37243152	F140V	3CLpro	ORF1a	COVID-19	D G L	View
42	37243152	G15C	3CLpro	ORF1a	COVID-19	D G L	View
43	37243152	G15G	3CLpro	ORF1a	COVID-19	D G L	View
44	37243152	G15R	3CLpro	ORF1a	COVID-19	D G L	View
45	37243152	H172R	3CLpro	ORF1a	COVID-19	D G L	View
46	37243152	L50C	3CLpro	ORF1a	COVID-19	D G L	View
47	37243152	L50S	3CLpro	ORF1a	COVID-19	D G L	View
48	37243152	L50Y	3CLpro	ORF1a	COVID-19	D G L	View
49	37243152	P252L	3CLpro	ORF1a	COVID-19	D G L	View
50	37243152	Q192K	3CLpro	ORF1a	COVID-19	D G L	View
51	37243152	Q192L	3CLpro	ORF1a	COVID-19	D G L	View
52	37243152	Q192P	3CLpro	ORF1a	COVID-19	D G L	View
53	37243152	Q192R	3CLpro	ORF1a	COVID-19	D G L	View
54	37243152	S144L	3CLpro	ORF1a	COVID-19	D G L	View
55	37243152	T21N	3CLpro	ORF1a	COVID-19	D G L	View
56	37243152	T21S	3CLpro	ORF1a	COVID-19	D G L	View
57	37243152	V186A	3CLpro	ORF1a	COVID-19	D G L	View
58	37243152	V186D	3CLpro	ORF1a	COVID-19	D G L	View
59	37243152	V186G	3CLpro	ORF1a	COVID-19	D G L	View
60	37243152	V186V	3CLpro	ORF1a	COVID-19	D G L	View
61	37243152	L50F	3CLpro	ORF1a	COVID-19	D G L	View
62	37243152	L50I	3CLpro	ORF1a	COVID-19	D G L	View
63	37243152	L50L	3CLpro	ORF1a	COVID-19	D G L	View
64	37243152	L50V	3CLpro	ORF1a	COVID-19	D G L	View
65	37243279	T24I	3CLpro	ORF1a	COVID-19	G R S C L	View
66	37243279	G15S	3CLpro	ORF1a	COVID-19	G R S C L	View
67	37243152	M49M	3CLpro	ORF1a	COVID-19	D G L	View
68	37243152	M49T	3CLpro	ORF1a	COVID-19	D G L	View
69	37060743	T21I	3CLpro	ORF1a	COVID-19	D G L	View
70	37060743	G15S	3CLpro	ORF1a	COVID-19	D G L	View
71	35079088	P108S	3CLpro	ORF1a	COVID-19	G	View
72	38793600	C10116T	3CLpro	ORF1a	COVID-19	G R C L	View
73	38793600	T21I	3CLpro	ORF1a	COVID-19	D G R C L	View
74	37243152	A173T	3CLpro	ORF1a	COVID-19	D G L	View
75	37243152	A173V	3CLpro	ORF1a	COVID-19	D G L	View
76	37181765	H41H	3CLpro	ORF1a	COVID-19		View
77	38058248	G11S	3CLpro	ORF1a	COVID-19	R	View
78	37060743	A173T	3CLpro	ORF1a	COVID-19	D	View
79	37060743	A173V	3CLpro	ORF1a	COVID-19	D	View
80	37060743	D248E	3CLpro	ORF1a	COVID-19	D	View
81	37060743	D48Y	3CLpro	ORF1a	COVID-19	D	View
82	37060743	E166A	3CLpro	ORF1a	COVID-19	D	View
83	37060743	E166G	3CLpro	ORF1a	COVID-19	D	View
84	37060743	E166V	3CLpro	ORF1a	COVID-19	D	View
85	37060743	F140A	3CLpro	ORF1a	COVID-19	D	View
86	37060743	F140L	3CLpro	ORF1a	COVID-19	D	View
87	37060743	H164N	3CLpro	ORF1a	COVID-19	D	View
88	37060743	H172F	3CLpro	ORF1a	COVID-19	D	View
89	37060743	H172Q	3CLpro	ORF1a	COVID-19	D	View
90	37060743	H172Y	3CLpro	ORF1a	COVID-19	D	View
91	37060743	L167F	3CLpro	ORF1a	COVID-19	D	View
92	37060743	L50F	3CLpro	ORF1a	COVID-19	D	View
93	37060743	M165T	3CLpro	ORF1a	COVID-19	D	View
94	37060743	M49I	3CLpro	ORF1a	COVID-19	D	View
95	37060743	M49L	3CLpro	ORF1a	COVID-19	D	View
96	37060743	P252L	3CLpro	ORF1a	COVID-19	D	View
97	37060743	Q189K	3CLpro	ORF1a	COVID-19	D	View
98	37060743	Q192L	3CLpro	ORF1a	COVID-19	D	View
99	37060743	Q192P	3CLpro	ORF1a	COVID-19	D	View
100	37060743	Q192S	3CLpro	ORF1a	COVID-19	D	View
101	37060743	Q192T	3CLpro	ORF1a	COVID-19	D	View
102	37060743	S144A	3CLpro	ORF1a	COVID-19	D	View
103	37060743	S144E	3CLpro	ORF1a	COVID-19	D	View
104	37060743	S144F	3CLpro	ORF1a	COVID-19	D	View
105	37060743	S144G	3CLpro	ORF1a	COVID-19	D	View
106	37060743	S144T	3CLpro	ORF1a	COVID-19	D	View
107	37060743	T135I	3CLpro	ORF1a	COVID-19	D	View
108	37060743	T304I	3CLpro	ORF1a	COVID-19	D	View
109	37060743	T45I	3CLpro	ORF1a	COVID-19	D	View
110	37060743	V186G	3CLpro	ORF1a	COVID-19	D	View
111	37060743	Y54A	3CLpro	ORF1a	COVID-19	D	View
112	37060743	Y54C	3CLpro	ORF1a	COVID-19	D	View
113	37947496	E166A	3CLpro	ORF1a	Cell line	D G	View
114	37947496	S144A	3CLpro	ORF1a	Cell line	D G	View
115	37402789	E166A	3CLpro	ORF1a	Cell line	D G R S	View
116	37402789	E166V	3CLpro	ORF1a	Cell line	D G R S	View
117	37402789	L167F	3CLpro	ORF1a	Cell line	D G R S	View
118	37402789	L50F	3CLpro	ORF1a	Cell line	D G R S	View