All Curated Mutation Sites in HBV 
Back to Mutation Home

 The Virus Mutation(VM) module provides researchers the annotations of reported pathogenic mutations in HBV related to human diseases. The curated VM information includes mutation site, mutation level, virus gene/protein/region, virus-associated disease, genotype/subtype, literature evidence, etc.


Browse Data by Virus Gene/Protein/Region, Disease OR Description
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For highly variable viruses (e.g., HBV, HIV, SARS-CoV-2), ViMIC defaults to displaying mutations in a specific region. Click the green button to search for other regions, or click "Show All" to view all mutations (loading speed may be affected by network conditions).

Show All
  
S
  
BCP
  
X
  
C
  
Core Promoter
  
Core Upstream Regulatory Sequence
  
DR1
  
EnhI
  
EnhII
  
PreC
  
P
  
PreC Promoter
  
PreS
  
PreS1
  
PreS1 Promoter
  
PreS2
  
RT
  
S Promoter
  
S1 Promoter
  
S2 Promoter
  
X Promoter
  

Keyword: EnhII
ID PMID Mutation Gene/Protein/Region Encoding Gene/Protein Disease Description Detail
1 26647737 G1719T
EnhII
Hepatitis B, Chronic
G
C
L
View
2 31324819 C1653T
EnhII
Hepatitis B, Chronic
G
R
View
3 31359359 C1653T
EnhII
Hepatitis B, Chronic
D
G
R
C
L
View
4 34920100 A1635T
EnhII
Hepatitis B, Chronic
Liver Cirrhosis
G
R
C
L
View
5 34920100 C1678T
EnhII
Hepatitis B, Chronic
Liver Cirrhosis
G
R
C
L
View
6 34920100 A1633G
EnhII
Hepatitis B, Chronic
Liver Cirrhosis
G
R
C
L
View
7 34920100 A1635G
EnhII
Hepatitis B, Chronic
Liver Cirrhosis
G
R
C
L
View
8 18551606 H94Y
EnhII
Hepatitis B, Chronic
Liver Cirrhosis
Carcinoma, Hepatocellular
G
C
L
View
9 21063480 A1846C
EnhII;BCP;PreC
C
Carcinoma, Hepatocellular
G
C
L
View
10 21063480 A1846T
EnhII;BCP;PreC
C
Carcinoma, Hepatocellular
G
C
L
View
11 21063480 C1653T
EnhII;BCP;PreC
C
Carcinoma, Hepatocellular
G
C
L
View
12 21063480 C1766T
EnhII;BCP;PreC
C
Carcinoma, Hepatocellular
G
C
L
View
13 21063480 G1613A
EnhII;BCP;PreC
C
Carcinoma, Hepatocellular
G
C
L
View
14 21063480 G1896A
EnhII;BCP;PreC
C
Carcinoma, Hepatocellular
G
C
L
View
15 21063480 T1768A
EnhII;BCP;PreC
C
Carcinoma, Hepatocellular
G
C
L
View
16 21063480 T1858C
EnhII;BCP;PreC
C
Carcinoma, Hepatocellular
G
C
L
View
17 21063480 A1762T
EnhII;BCP;PreC
C
Carcinoma, Hepatocellular
G
C
L
View
18 21063480 G1764A
EnhII;BCP;PreC
C
Carcinoma, Hepatocellular
G
C
L
View
19 21063480 G1899A
EnhII;BCP;PreC
C
Carcinoma, Hepatocellular
G
C
L
View
20 21063480 T1753A
EnhII;BCP;PreC
C
Carcinoma, Hepatocellular
G
C
L
View
21 21063480 T1753C
EnhII;BCP;PreC
C
Carcinoma, Hepatocellular
G
C
L
View
22 21108338 A1652G
EnhII
Carcinoma, Hepatocellular
G
C
L
View
23 21108338 C1653T
EnhII
Carcinoma, Hepatocellular
G
C
L
View
24 21108338 C1673T
EnhII
Carcinoma, Hepatocellular
G
C
L
View
25 21108338 C1730G
EnhII
Carcinoma, Hepatocellular
G
C
L
View
26 21108338 G1727A
EnhII
Carcinoma, Hepatocellular
G
C
L
View
27 21108338 G1727T
EnhII
Carcinoma, Hepatocellular
G
C
L
View
28 21108338 T1674G
EnhII
Carcinoma, Hepatocellular
G
C
L
View
29 21108338 T1719G
EnhII
Carcinoma, Hepatocellular
G
C
L
View
30 23386590 A1652G
EnhII
Carcinoma, Hepatocellular
G
S
C
L
View
31 23386590 A1727G
EnhII
Carcinoma, Hepatocellular
G
S
C
L
View
32 23386590 A1727T
EnhII
Carcinoma, Hepatocellular
G
S
C
L
View
33 23386590 C1653T
EnhII
Carcinoma, Hepatocellular
G
S
C
L
View
34 23386590 C1673T
EnhII
Carcinoma, Hepatocellular
G
S
C
L
View
35 23386590 C1730G
EnhII
Carcinoma, Hepatocellular
G
S
C
L
View
36 23386590 G1719T
EnhII
Carcinoma, Hepatocellular
G
S
C
L
View
37 23516510 G1896A
EnhII;BCP;PreC
C
Carcinoma, Hepatocellular
G
C
L
View
38 23516510 T1674C
EnhII;BCP;PreC
C
Carcinoma, Hepatocellular
G
C
L
View
39 23516510 T1674G
EnhII;BCP;PreC
C
Carcinoma, Hepatocellular
G
C
L
View
40 23516510 C1730G
EnhII;BCP;PreC
C
Carcinoma, Hepatocellular
G
C
L
View
41 23516510 C1653T
EnhII;BCP;PreC
C
Carcinoma, Hepatocellular
G
C
L
View
42 23516510 G1764A
EnhII;BCP;PreC
C
Carcinoma, Hepatocellular
G
C
L
View
43 23516510 T1753V
EnhII;BCP;PreC
C
Carcinoma, Hepatocellular
G
C
L
View
44 23516510 A1762T
EnhII;BCP;PreC
C
Carcinoma, Hepatocellular
G
C
L
View
45 23621183 C1653T
EnhII
Carcinoma, Hepatocellular
G
View
46 24118778 T1674C
EnhII
Carcinoma, Hepatocellular
C
L
View
47 24118778 T1674G
EnhII
Carcinoma, Hepatocellular
C
L
View
48 24748463 T1674C
EnhII
Carcinoma, Hepatocellular
G
C
L
View
49 24748463 T1674G
EnhII
Carcinoma, Hepatocellular
G
C
L
View
50 26543337 C1653T
EnhII
Carcinoma, Hepatocellular
G
View
51 33381105 C1653T
EnhII
Carcinoma, Hepatocellular
G
R
S
L
View
52 36292082 C1653T
EnhII;X
X
Carcinoma, Hepatocellular
G
C
L
View
53 36292082 G1613A
EnhII;X
X
Carcinoma, Hepatocellular
G
C
L
View
54 36292082 G1721A
EnhII;X
X
Carcinoma, Hepatocellular
G
C
L
View
55 36292082 H94Y
EnhII;X
X
Carcinoma, Hepatocellular
G
C
L
View
56 18844615 C1653T
EnhII
Carcinoma, Hepatocellular
Hepatitis B, Chronic
Liver Cirrhosis
L
View
57 35880842 C1913A
EnhII;BCP;PreC
C
Carcinoma, Hepatocellular
Hepatitis B, Chronic
Liver Cirrhosis
G
C
L
View
58 35880842 T1674C
EnhII;BCP;PreC
C
Carcinoma, Hepatocellular
Hepatitis B, Chronic
Liver Cirrhosis
G
C
L
View
59 35880842 A1762T
EnhII;BCP;PreC
C
Carcinoma, Hepatocellular
Hepatitis B, Chronic
Liver Cirrhosis
G
C
L
View
60 35880842 C1653T
EnhII;BCP;PreC
C
Carcinoma, Hepatocellular
Hepatitis B, Chronic
Liver Cirrhosis
G
C
L
View
61 35880842 G1764A
EnhII;BCP;PreC
C
Carcinoma, Hepatocellular
Hepatitis B, Chronic
Liver Cirrhosis
G
C
L
View
62 35880842 G1899A
EnhII;BCP;PreC
C
Carcinoma, Hepatocellular
Hepatitis B, Chronic
Liver Cirrhosis
G
C
L
View
63 35880842 T1768A
EnhII;BCP;PreC
C
Carcinoma, Hepatocellular
Hepatitis B, Chronic
Liver Cirrhosis
G
C
L
View
64 35880842 A1726C
EnhII;BCP;PreC
C
Carcinoma, Hepatocellular
Hepatitis B, Chronic
Liver Cirrhosis
G
C
L
View
65 38037048 A1762T
EnhII;BCP;PreC
C
Carcinoma, Hepatocellular
Hepatitis B, Chronic
Liver Cirrhosis
G
C
L
T
View
66 38037048 A1846T
EnhII;BCP;PreC
C
Carcinoma, Hepatocellular
Hepatitis B, Chronic
Liver Cirrhosis
G
C
L
T
View
67 38037048 C1653T
EnhII;BCP;PreC
C
Carcinoma, Hepatocellular
Hepatitis B, Chronic
Liver Cirrhosis
G
C
L
T
View
68 38037048 G1719T
EnhII;BCP;PreC
C
Carcinoma, Hepatocellular
Hepatitis B, Chronic
Liver Cirrhosis
G
C
L
T
View
69 38037048 G1764A
EnhII;BCP;PreC
C
Carcinoma, Hepatocellular
Hepatitis B, Chronic
Liver Cirrhosis
G
C
L
T
View
70 38037048 G1896A
EnhII;BCP;PreC
C
Carcinoma, Hepatocellular
Hepatitis B, Chronic
Liver Cirrhosis
G
C
L
T
View
71 38037048 G1899A
EnhII;BCP;PreC
C
Carcinoma, Hepatocellular
Hepatitis B, Chronic
Liver Cirrhosis
G
C
L
T
View
72 38037048 T1674C
EnhII;BCP;PreC
C
Carcinoma, Hepatocellular
Hepatitis B, Chronic
Liver Cirrhosis
G
C
L
T
View
73 38037048 T1674G
EnhII;BCP;PreC
C
Carcinoma, Hepatocellular
Hepatitis B, Chronic
Liver Cirrhosis
G
C
L
T
View
74 38037048 T1753A
EnhII;BCP;PreC
C
Carcinoma, Hepatocellular
Hepatitis B, Chronic
Liver Cirrhosis
G
C
L
T
View
75 38037048 T1753C
EnhII;BCP;PreC
C
Carcinoma, Hepatocellular
Hepatitis B, Chronic
Liver Cirrhosis
G
C
L
T
View
76 22095534 C1726A
EnhII
Liver Diseases
G
C
L
View
77 19431214 G1721A
EnhII
Occult HBV Infection
Carcinoma, Hepatocellular
G
R
C
L
View
78 20173647 C1653T
EnhII
Hepatitis B Virus Infection
G
L
View
79 23346148 G1730C
EnhII
Hepatitis B Virus Infection
G
C
L
View
80 23346148 T1727A
EnhII
Hepatitis B Virus Infection
G
C
L
View
81 23346148 C1726A
EnhII
Hepatitis B Virus Infection
G
C
L
View
82 23346148 G1719T
EnhII
Hepatitis B Virus Infection
G
C
L
View
83 23903967 A1762T
EnhII
Hepatitis B Virus Infection
G
R
S
C
L
View
84 23903967 G1764A
EnhII
Hepatitis B Virus Infection
G
R
S
C
L
View
85 23903967 G1896A
EnhII
Hepatitis B Virus Infection
G
R
S
C
L
View
86 23903967 G1613A
EnhII
Hepatitis B Virus Infection
G
R
S
C
L
View
87 25333524 C1653T
EnhII
Hepatitis B Virus Infection
G
S
C
L
View
88 10745228 C1653T
EnhII
Fulminant Hepatitis B
Acute Hepatitis B
L
View
89 10745228 T1753M
EnhII
Fulminant Hepatitis B
Acute Hepatitis B
G
L
View
90 31434918 C1653T
EnhII
Hepatitis B Virus Infection
G
C
L
View
91 34982798 1610_1614del
EnhII
Hepatitis B Virus Infection
G
R
C
L
View
92 34982798 1630_1635del
EnhII
Hepatitis B Virus Infection
G
R
C
L
View
93 34982798 1653_1655del
EnhII
Hepatitis B Virus Infection
G
R
C
L
View
94 34982798 1717_1721del
EnhII
Hepatitis B Virus Infection
G
R
C
L
View
95 34982798 1718_1721del
EnhII
Hepatitis B Virus Infection
G
R
C
L
View
96 34982798 1726_del
EnhII
Hepatitis B Virus Infection
G
R
C
L
View
97 34982798 1731_del
EnhII
Hepatitis B Virus Infection
G
R
C
L
View
98 34982798 94delH
EnhII
Hepatitis B Virus Infection
G
R
C
L
View
99 34982798 A102G
EnhII
Hepatitis B Virus Infection
G
R
C
L
View
100 34982798 A102I
EnhII
Hepatitis B Virus Infection
G
R
C
L
View
101 34982798 A102R
EnhII
Hepatitis B Virus Infection
G
R
C
L
View
102 34982798 A102V
EnhII
Hepatitis B Virus Infection
G
R
C
L
View
103 34982798 A110K
EnhII
Hepatitis B Virus Infection
G
R
C
L
View
104 34982798 A110S
EnhII
Hepatitis B Virus Infection
G
R
C
L
View
105 34982798 D107R
EnhII
Hepatitis B Virus Infection
G
R
C
L
View
106 34982798 D114G
EnhII
Hepatitis B Virus Infection
G
R
I
C
L
View
107 34982798 D119N
EnhII
Hepatitis B Virus Infection
G
R
I
C
L
View
108 34982798 E109A
EnhII
Hepatitis B Virus Infection
G
R
C
L
View
109 34982798 E109Y
EnhII
Hepatitis B Virus Infection
G
R
C
L
View
110 34982798 F112L
EnhII
Hepatitis B Virus Infection
G
R
I
C
L
View
111 34982798 F117S
EnhII
Hepatitis B Virus Infection
G
R
I
C
L
View
112 34982798 K113E
EnhII
Hepatitis B Virus Infection
G
R
I
C
L
View
113 34982798 K118E
EnhII
Hepatitis B Virus Infection
G
R
I
C
L
View
114 34982798 K118I
EnhII
Hepatitis B Virus Infection
G
R
I
C
L
View
115 34982798 K91R
EnhII
Hepatitis B Virus Infection
G
R
C
L
View
116 34982798 K91W
EnhII
Hepatitis B Virus Infection
G
R
C
L
View
117 34982798 K95S
EnhII
Hepatitis B Virus Infection
G
R
C
L
View
118 34982798 L100G
EnhII
Hepatitis B Virus Infection
G
R
C
L
View
119 34982798 L108P
EnhII
Hepatitis B Virus Infection
G
R
C
L
View
120 34982798 L93P
EnhII
Hepatitis B Virus Infection
G
R
C
L
View
121 34982798 M103A
EnhII
Hepatitis B Virus Infection
G
R
C
L
View
122 34982798 M103L
EnhII
Hepatitis B Virus Infection
G
R
C
L
View
123 34982798 P90F
EnhII
Hepatitis B Virus Infection
G
R
C
L
View
124 34982798 R96C
EnhII
Hepatitis B Virus Infection
G
R
C
L
View
125 34982798 S101F
EnhII
Hepatitis B Virus Infection
G
R
C
L
View
126 34982798 S104I
EnhII
Hepatitis B Virus Infection
G
R
C
L
View
127 34982798 S104W
EnhII
Hepatitis B Virus Infection
G
R
C
L
View
128 34982798 T106I
EnhII
Hepatitis B Virus Infection
G
R
C
L
View
129 34982798 T106N
EnhII
Hepatitis B Virus Infection
G
R
C
L
View
130 34982798 T97A
EnhII
Hepatitis B Virus Infection
G
R
C
L
View
131 34982798 V92A
EnhII
Hepatitis B Virus Infection
G
R
C
L
View
132 34982798 V92P
EnhII
Hepatitis B Virus Infection
G
R
C
L
View
133 34982798 Y111D
EnhII
Hepatitis B Virus Infection
G
R
C
L
View
134 34982798 Y111E
EnhII
Hepatitis B Virus Infection
G
R
C
L
View
135 19574418 C1653T
EnhII
Hepatitis B Virus Infection
Carcinoma, Hepatocellular
G
S
View
136 19998495 C1653T
EnhII;BCP;PreC
C
Hepatitis B Virus Infection
Carcinoma, Hepatocellular
View
137 24006435 A1727T
EnhII;BCP;PreC
C
Hepatitis B, Chronic
G
S
C
View
138 24006435 A1846T
EnhII;BCP;PreC
C
Hepatitis B, Chronic
G
S
C
View
139 24006435 C1653T
EnhII;BCP;PreC
C
Hepatitis B, Chronic
G
S
C
View
140 24006435 G1652A
EnhII;BCP;PreC
C
Hepatitis B, Chronic
G
S
C
View
141 24006435 G1719T
EnhII;BCP;PreC
C
Hepatitis B, Chronic
G
S
C
View
142 24006435 G1730C
EnhII;BCP;PreC
C
Hepatitis B, Chronic
G
S
C
View
143 24006435 G1799C
EnhII;BCP;PreC
C
Hepatitis B, Chronic
G
S
C
View
144 24006435 G1896A
EnhII;BCP;PreC
C
Hepatitis B, Chronic
G
S
C
View
145 24006435 T1673C
EnhII;BCP;PreC
C
Hepatitis B, Chronic
G
S
C
View
146 24006435 T1674C
EnhII;BCP;PreC
C
Hepatitis B, Chronic
G
S
C
View
147 24006435 T1674G
EnhII;BCP;PreC
C
Hepatitis B, Chronic
G
S
C
View
148 24006435 C1673T
EnhII;BCP;PreC
C
Hepatitis B, Chronic
S
C
View
149 24006435 C1730G
EnhII;BCP;PreC
C
Hepatitis B, Chronic
S
C
View
150 24006435 C1799G
EnhII;BCP;PreC
C
Hepatitis B, Chronic
S
C
View
151 24006435 A1762T
EnhII;BCP;PreC
C
Hepatitis B, Chronic
G
S
C
View
152 24006435 G1764A
EnhII;BCP;PreC
C
Hepatitis B, Chronic
G
S
C
View
153 24006435 G1899A
EnhII;BCP;PreC
C
Hepatitis B, Chronic
G
S
C
View
154 24006435 T1753C
EnhII;BCP;PreC
C
Hepatitis B, Chronic
G
S
C
View
Contents
Description

The table shows all curated mutation sites of HBV in each literature

Table Description Column Note
D
The study mentioned a certain treatment method, such as drug resistance caused by mutations.
G
The study mentioned the virus genotype/subtype information.
R
The study mentioned the reference sequence used for comparison, or the original strain of the virus used for site-directed mutagenesis.
S
The study provided sequence information or accession numbers.
L
The study provided the geographic region/country of data origin.
C
The study provided clinical baseline information.
I
The study involved information related to immune.
T
The study involved host target genes.