*Please select one option you are interested in, the page will be automatically redirected.

Virus Gene/Protein ORF1a ORF1b ORF3a S E M N ORF7a ORF7b ORF8 ORF1ab ORF9b ORF10 ORF6 ORF9c

Disease COVID-19 Cell line Cystic Fibrosis Pediatric Multisystem Inflammatory Disease, COVID-19 related Thrombosis, COVID-19 related HIV Infections

Description Genotype/Subtype Immune Target gene Clinical data Treatment Location Sequence data

For highly variable viruses (e.g., HBV, HIV, SARS-CoV-2), ViMIC defaults to displaying mutations in a specific region. Click the green button to search for other regions, or click "Show All" to view all mutations (loading speed may be affected by network conditions).

Show All

  

ORF1a

  

ORF1b

  

ORF3a

  

3CLpro

  

3'UTR

  

5'UTR

  

RBD

  

ORF7b-ORF8

  

upstream of N

  

Furin cleavage site

  

E

  

endoRNase

  

Exonuclease

  

S

  

NSP13

  

NSP3

  

M

  

Mpro

  

Methyltransferase

  

N

  

NSP14

  

NSP12

  

Non-coding region

  

NP

  

NS3

  

NS7a

  

NS7b

  

NS8

  

NSP5

  

NSP1

  

NSP10

  

NSP11

  

NSP15

  

NSP16

  

NSP2

  

NSP4

  

NSP6

  

NSP7

  

NSP8

  

NSP9

  

NTD

  

ORF8

  

ORF1ab

  

ORF9b

  

ORF10

  

ORF3

  

ORF6

  

ORF7a

  

ORF7b

  

ORF9

  

ORF9c

  

PLpro

  

RdRp

  

RBM

  

Replicase

  

RNA primase

  

• Mutation
• Sequence

ID	PMID	Mutation	Gene/Protein/Region	Encoding Gene/Protein	Disease	Description	Detail
1	35317858	E375A	NSP13	ORF1b	Cell line		View
2	35317858	K345A	NSP13	ORF1b	Cell line		View
3	35317858	K347A	NSP13	ORF1b	Cell line		View
4	36512569	C16391T	NSP13	ORF1b		G R L	View
5	36512569	C16726T	NSP13	ORF1b		G R L	View
6	36512569	A52V	NSP13	ORF1b		G R L	View
7	36512569	H164Y	NSP13	ORF1b		G R L	View
8	36512569	A17615G	NSP13	ORF1b		G R L	View
9	36512569	K460R	NSP13	ORF1b		G R L	View
10	36686884	T416V	NSP13	ORF1b		R L	View
11	36686884	N423N	NSP13	ORF1b		R L	View
12	36686884	N423K	NSP13	ORF1b		R L	View
13	36686884	L417V	NSP13	ORF1b		R L	View
14	35706980	R5661C	NSP13	ORF1b		S C L	View
15	33391880	M576I	NSP13	ORF1b	COVID-19	G R S L	View
16	35966679	P77L	NSP13	ORF1b	COVID-19	G L	View
17	36590492	P77L	NSP13	ORF1b	COVID-19	G R S L	View
18	36560614	T481M	NSP13	ORF1b	COVID-19	G	View
19	37224159	C16887T	NSP13	ORF1b	COVID-19	G R L	View
20	37224159	R392C	NSP13	ORF1b	COVID-19	G R L	View
21	37224159	Y217Y	NSP13	ORF1b	COVID-19	G R L	View
22	39227954	Y324C	NSP13	ORF1b	COVID-19	G R L	View
23	34925297	P77L	NSP13	ORF1b	COVID-19	G R I	View
24	34925297	M429I	NSP13	ORF1b	COVID-19	G R I	View
25	36687433	M233I	NSP13	ORF1b	COVID-19	G R S L	View
26	34925297	Q88H	NSP13	ORF1b	COVID-19	G R I	View
27	35966679	G439R	NSP13	ORF1b	COVID-19	G L	View
28	34925297	D260Y	NSP13	ORF1b	COVID-19	G R I	View
29	34925297	E341D	NSP13	ORF1b	COVID-19	G R I	View
30	35992703	I334V	NSP13	ORF1b	COVID-19	G L	View
31	35992703	Y541C	NSP13	ORF1b	COVID-19	G L	View
32	35992703	D204E	NSP13	ORF1b	COVID-19	G L	View
33	35992703	A598V	NSP13	ORF1b	COVID-19	G L	View
34	35966679	E261D	NSP13	ORF1b	COVID-19	G L	View
35	38791536	S486L	NSP13	ORF1b	COVID-19	R L	View
36	38791536	S468L	NSP13	ORF1b	COVID-19	R L	View
37	38605705	T16456C	NSP13	ORF1b	COVID-19	G R S C L	View
38	38605705	C16616A	NSP13	ORF1b	COVID-19	G R S C L	View
39	38605705	C16887T	NSP13	ORF1b	COVID-19	G R S C L	View
40	38605705	T17208C	NSP13	ORF1b	COVID-19	G R S C L	View
41	38605705	C17410T	NSP13	ORF1b	COVID-19	G R S C L	View
42	38605705	S74P	NSP13	ORF1b	COVID-19	G R S C L	View
43	38605705	T127N	NSP13	ORF1b	COVID-19	G R S C L	View
44	38605705	R392C	NSP13	ORF1b	COVID-19	G R S C L	View
45	40281619	T127N	NSP13	ORF1b	COVID-19	C L	View
46	36090111	K1062K	NSP13	ORF1b	COVID-19	R C L	View
47	36090111	K1383R	NSP13	ORF1b	COVID-19	R C L	View
48	36090111	P1000L	NSP13	ORF1b	COVID-19	R C L	View
49	36090111	T903T	NSP13	ORF1b	COVID-19	R C L	View
50	36841805	P77L	NSP13	ORF1b	COVID-19	R	View
51	35614572	R292C	NSP13	ORF1b	COVID-19	R	View
52	35707124	S259L	NSP13	ORF1b	COVID-19	R L	View
53	35759503	A85P	NSP13	ORF1b	COVID-19	R L	View
54	35759503	G16489C	NSP13	ORF1b	COVID-19	R L	View
55	35913920	P504L	NSP13	ORF1b	COVID-19	R	View
56	35913920	Y541C	NSP13	ORF1b	COVID-19	R	View
57	33384909	A5770D	NSP13	ORF1b	COVID-19	R	View
58	33384909	I5582V	NSP13	ORF1b	COVID-19	R	View
59	35891618	L138L	NSP13	ORF1b	COVID-19	S L	View
60	35891618	L227L	NSP13	ORF1b	COVID-19	S L	View
61	35891618	P77L	NSP13	ORF1b	COVID-19	S L	View
62	38348230	R155C	NSP13	ORF1b	COVID-19	C L	View
63	38348230	R579K	NSP13	ORF1b	COVID-19	C L	View
64	37529147	R392C	NSP13	ORF1b	COVID-19	R S L	View
65	33347622	P504L	NSP13	ORF1b	COVID-19		View
66	33347622	C541Y	NSP13	ORF1b	COVID-19		View
67	33622851	P409L	NSP13	ORF1b	COVID-19	R	View
68	33622851	Y446C	NSP13	ORF1b	COVID-19	R	View
69	33932525	S5398L	NSP13	ORF1b	COVID-19	R C L	View
70	34419925	K460R	NSP13	ORF1b	COVID-19	L	View
71	32793182	Y541C	NSP13	ORF1b	COVID-19	R	View
72	32793182	P504L	NSP13	ORF1b	COVID-19	R	View
73	32904401	Y541C	NSP13	ORF1b	COVID-19	R	View
74	32980406	A17858G	NSP13	ORF1b	COVID-19	R S	View
75	32980406	C17747T	NSP13	ORF1b	COVID-19	R S	View
76	33357233	P504L	NSP13	ORF1b	COVID-19	R	View
77	33357233	S539A	NSP13	ORF1b	COVID-19	R	View
78	33357233	S539Y	NSP13	ORF1b	COVID-19	R	View
79	33357233	V49I	NSP13	ORF1b	COVID-19	R	View
80	33357233	Y541A	NSP13	ORF1b	COVID-19	R	View
81	33357233	Y541C	NSP13	ORF1b	COVID-19	R	View
82	33920487	K218R	NSP13	ORF1b	COVID-19	R	View
83	33920487	E261D	NSP13	ORF1b	COVID-19	R	View
84	33920487	H290Y	NSP13	ORF1b	COVID-19	R	View
85	38435775	P77L	NSP13	ORF1b	COVID-19	C L	View
86	36008511	A5376V	NSP13	ORF1b	COVID-19	R C L	View
87	36008511	D5584Y	NSP13	ORF1b	COVID-19	R C L	View
88	36008511	A5620S	NSP13	ORF1b	COVID-19	R C L	View
89	36008511	N5827Y	NSP13	ORF1b	COVID-19	R C L	View
90	36008511	V5493F	NSP13	ORF1b	COVID-19	R C L	View
91	38364100	L1220F	NSP13	ORF1b	COVID-19	R S	View
92	38364100	L1220I	NSP13	ORF1b	COVID-19	R S	View
93	32595354	S485L	NSP13	ORF1b	COVID-19	R L	View
94	40358207	M233I	NSP13	ORF1b	Cell line	G	View
95	39047088	S468L	NSP13	ORF1b	Cell line	R S	View
96	39047088	K94N	NSP13	ORF1b	Cell line	R S	View
97	39047088	N1543K	NSP13	ORF1b	Cell line	R S	View