SARS-CoV-2 Mutation Detail Information

Virus Mutation SARS-CoV-2 Mutation 144delY


Basic Characteristics of Mutations
Mutation Site 144delY
Mutation Site Sentence The spike protein substitutions observed in C.1.2 include five within the N-terminal domain (NTD: C136F, Y144del, R190S, D215G, and 242-243del or 243-244del (either deletion results in the same amino acid sequence)), three within the receptor binding motif (RBM: Y449H, E484K, and N501Y) and three adjacent to the furin cleavage site (H655Y, N679K, and T716I) (Fig.
Mutation Level Amino acid level
Mutation Type Deletion
Gene/Protein/Region S
Standardized Encoding Gene S  
Genotype/Subtype C.1.2
Viral Reference NC_045512.2;MN908947.3
Functional Impact and Mechanisms
Disease -
Immune -
Target Gene -
Clinical and Epidemiological Correlations
Clinical Information -
Treatment -
Location South Africa
Literature Information
PMID 35396511
Title Emergence and phenotypic characterization of the global SARS-CoV-2 C.1.2 lineage
Author Scheepers C,Everatt J,Amoako DG,Tegally H,Wibmer CK,Mnguni A,Ismail A,Mahlangu B,Lambson BE,Martin DP,Wilkinson E,San JE,Giandhari J,Manamela N,Ntuli N,Kgagudi P,Cele S,Richardson SI,Pillay S,Mohale T,Ramphal U,Naidoo Y,Khumalo ZT,Kwatra G,Gray G,Bekker LG,Madhi SA,Baillie V,Van Voorhis WC,Treurnicht FK,Venter M,Mlisana K,Wolter N,Sigal A,Williamson C,Hsiao NY,Msomi N,Maponga T,Preiser W,Makatini Z,Lessells R,Moore PL,de Oliveira T,von Gottberg A,Bhiman JN
Journal Nature communications
Journal Info 2022 Apr 8;13(1):1976
Abstract Global genomic surveillance of SARS-CoV-2 has identified variants associated with increased transmissibility, neutralization resistance and disease severity. Here we report the emergence of the PANGO lineage C.1.2, detected at low prevalence in South Africa and eleven other countries. The initial C.1.2 detection is associated with a high substitution rate, and includes changes within the spike protein that have been associated with increased transmissibility or reduced neutralization sensitivity in SARS-CoV-2 variants of concern or variants of interest. Like Beta and Delta, C.1.2 shows significantly reduced neutralization sensitivity to plasma from vaccinees and individuals infected with the ancestral D614G virus. In contrast, convalescent donors infected with either Beta or Delta show high plasma neutralization against C.1.2. These functional data suggest that vaccine efficacy against C.1.2 will be equivalent to Beta and Delta, and that prior infection with either Beta or Delta will likely offer protection against C.1.2.
Sequence Data -
Mutation Information
Note
Basic Characteristics of Mutations
  • Mutation Site: The specific location in a gene or protein sequence where a change occurs.
  • Mutation Level: The level at which a mutation occurs, including the nucleotide or amino acid level.
  • Mutation Type: The nature of the mutation, such as missense mutation, nonsense mutation, synonymous mutation, etc.
  • Gene/Protein/Region: Refers to the specific region of the virus where the mutation occurs. Including viral genes, viral proteins, or a specific viral genome region. If the article does not specifically indicate the relationship between the mutation and its correspondence, the main
  • Gene/Protein/Region studied in the article is marked.
  • Genotype/Subtype: Refers to the viral genotype or subtype where the mutation occurs. If the article does not specifically indicate the relationship between the mutation and its correspondence, the main Genotype/Subtype studied in the article is marked.
  • Viral Reference: Refers to the standard virus strain used to compare and analyze viral sequences.
Functional Impact and Mechanisms
  • Disease: An abnormal physiological state with specific symptoms and signs caused by viral infection.
  • Immune: The article focuses on the study of mutations and immune.
  • Target Gene: Host genes that viral mutations may affect.
Clinical and Epidemiological Correlations
  • Clinical Information: The study is a clinical or epidemiological study and provides basic information about the population.
  • Treatment: The study mentioned a certain treatment method, such as drug resistance caused by mutations. If the study does not specifically indicate the relationship between mutations and their correspondence treatment, the main treatment studied in the article is marked.
  • Location: The source of the research data.
Literature Information
  • Sequence Data: The study provides the data accession number.