YFV Mutation Detail Information

Virus Mutation YFV Mutation A146V


Basic Characteristics of Mutations
Mutation Site A146V
Mutation Site Sentence Furthermore, an additional ongoing substitution (A146V) was identified in the NS4A gene of P20-2 strain, while another substitution (G196V) was found in the NS1 gene of P20-3 strain (marked in blue font in Table 1).
Mutation Level Amino acid level
Mutation Type Nonsynonymous substitution
Gene/Protein/Region NS4A
Standardized Encoding Gene NS4A
Genotype/Subtype -
Viral Reference JN628279;AY640589
Functional Impact and Mechanisms
Disease Cell line    
Immune -
Target Gene -
Clinical and Epidemiological Correlations
Clinical Information -
Treatment -
Location -
Literature Information
PMID 39398246
Title A safer cell-based yellow fever live attenuated vaccine protects mice against YFV infection
Author Guo W,Jiang T,Rao J,Zhang Z,Zhang X,Su J,Yin C,Lu M,Hu X,Shan C
Journal iScience
Journal Info 2024 Sep 17;27(10):110972
Abstract The live attenuated yellow fever vaccine (YF17D) has caused controversial safety issues in history with low-yield problems, which has led to a large population being unable to be vaccinated and vaccine shortage in facing recent outbreaks. Here, we report a safer live attenuated vaccine candidate, YF17D-Delta77, which contains 77 nucleotides deletion in the 3' untranslated region (3' UTR) of the YF17D genome. YF17D-Delta77 exhibited no neurotropism and decreased viscerotropism and caused significantly lower lethality in mice compared to YF17D. Mechanistically, the deletion enhanced the sensitivity of the virus to type I and type II interferon responses, which hindered viral replication. Encouragingly, YF17D-Delta77 provided comparable immune protection in mice as did YF17D. Even 10 PFU of YF17D-Delta77 completely protected mice against YFV-Asibi challenge. In addition, the Delta77 mutation showed excellent stability after successive passages in Vero cells. Collectively, the data suggest that further development of YF17D-Delta77 as vaccine candidate is warranted.
Sequence Data -
Mutation Information
Note
Basic Characteristics of Mutations
  • Mutation Site: The specific location in a gene or protein sequence where a change occurs.
  • Mutation Level: The level at which a mutation occurs, including the nucleotide or amino acid level.
  • Mutation Type: The nature of the mutation, such as missense mutation, nonsense mutation, synonymous mutation, etc.
  • Gene/Protein/Region: Refers to the specific region of the virus where the mutation occurs. Including viral genes, viral proteins, or a specific viral genome region. If the article does not specifically indicate the relationship between the mutation and its correspondence, the main
  • Gene/Protein/Region studied in the article is marked.
  • Genotype/Subtype: Refers to the viral genotype or subtype where the mutation occurs. If the article does not specifically indicate the relationship between the mutation and its correspondence, the main Genotype/Subtype studied in the article is marked.
  • Viral Reference: Refers to the standard virus strain used to compare and analyze viral sequences.
Functional Impact and Mechanisms
  • Disease: An abnormal physiological state with specific symptoms and signs caused by viral infection.
  • Immune: The article focuses on the study of mutations and immune.
  • Target Gene: Host genes that viral mutations may affect.
Clinical and Epidemiological Correlations
  • Clinical Information: The study is a clinical or epidemiological study and provides basic information about the population.
  • Treatment: The study mentioned a certain treatment method, such as drug resistance caused by mutations. If the study does not specifically indicate the relationship between mutations and their correspondence treatment, the main treatment studied in the article is marked.
  • Location: The source of the research data.
Literature Information
  • Sequence Data: The study provides the data accession number.