CHIKV Mutation Detail Information

Virus Mutation CHIKV Mutation A226V


Basic Characteristics of Mutations
Mutation Site A226V
Mutation Site Sentence The E1 A226V mutation was detected from autochthonous outbreaks, including Italy in 2007 and France in 2014 and 2017.
Mutation Level Amino acid level
Mutation Type Nonsynonymous substitution
Gene/Protein/Region E1
Standardized Encoding Gene E1
Genotype/Subtype -
Viral Reference -
Functional Impact and Mechanisms
Disease Chikungunya Fever    
Immune -
Target Gene -
Clinical and Epidemiological Correlations
Clinical Information -
Treatment -
Location Italy;France
Literature Information
PMID 40053531
Title Chikungunya virus in Europe: A retrospective epidemiology study from 2007 to 2023
Author Liu Q,Shen H,Gu L,Yuan H,Zhu W
Journal PLoS neglected tropical diseases
Journal Info 2025 Mar 7;19(3):e0012904
Abstract BACKGROUND: Chikungunya virus (CHIKV), a mosquito-borne alphavirus, is responsible for disease outbreaks worldwide. However, systematic knowledge of spatiotemporal distribution and risk patterns of CHIKV in mainland Europe remains unclear. Our aim was to decipher the epidemiological characteristics, diversity, and clinical manifestations of CHIKV. METHODS: In this retrospective study, we retrieved the surveillance bulletins of chikungunya infections reported in Europe during 2007-2023 to depict the epidemiological characteristics. We performed genotyping and phylogenetic analyses to examine the evolution and mutation. We also searched PubMed, Web of Science, and Google Scholar to conduct meta-analyses of clinical manifestations. RESULTS: 4730 chikungunya cases across twenty-two countries were documented in mainland Europe from 2007-2022, with no cases reported in 2023. The age-standardized incidence rate was highest in 2014 (0.31), with significant variations observed in each country per year. Although autochthonous outbreaks occurred in several countries, the majority of cases were travel-related, with individuals mainly getting infected during summer vacation. Most travel-related cases were reported as being acquired in India (11.7%), followed by Dominican Republic (9.0%), Guadeloupe (8.7%), and Thailand (7.8%). Genotyping of genome sequences identified two genotypes, with the majority belonging to II-ECSA. The E1 A226V mutation was detected from autochthonous outbreaks, including Italy in 2007 and France in 2014 and 2017. The most common symptoms reported were fever (97.6%), joint pain (94.3%), fatigue (63.5%), and skin rash (52.3%). CONCLUSION: The suitable niches for CHIKV are expanding due to climate change and global travel. With the absence of specific antiviral treatments and vaccines still in development, surveillance and vector control are essential in suppressing the re-emergence and epidemics of CHIKV.
Sequence Data EPI_ISL_17454873-EPI_ISL_17454876;EPI_ISL_17455499;EPI_ISL_17455726;EPI_ISL_17455796;EPI_ISL_17455798-EPI_ISL_17455800;EPI_ISL_17455803;EPI_ISL_17455804;EPI_ISL_17455808;EPI_ISL_17455809;EPI_ISL_17455812-EPI_ISL_17455819;EPI_ISL_17455821-EPI_ISL_17455825;EPI_ISL_17455827-EPI_ISL_17455837;EPI_ISL_17455839_EPI_ISL_17455844;EPI_ISL_17458068;EPI_ISL_17458069;EPI_ISL_17458071-EPI_ISL_17458073;EPI_ISL_17458082;EPI_ISL_17458415;EPI_ISL_17458684;EPI_ISL_17458751;EPI_ISL_17458755;EPI_ISL_17458920;EPI_ISL_17459935;EPI_ISL_17459939-EPI_ISL_17459941;EPI_ISL_17459944- EPI_ISL_17459946;EPI_ISL_17459948;EPI_ISL_17459949;EPI_ISL_17459951-EPI_ISL_17459955;EPI_ISL_17459957;EPI_ISL_17460710;EPI_ISL_17461258;EPI_ISL_17461259;EPI_ISL_17461283-EPI_ISL_17461286;EPI_ISL_17461337-EPI_ISL_17461340;EPI_ISL_17461546
Mutation Information
Note
Basic Characteristics of Mutations
  • Mutation Site: The specific location in a gene or protein sequence where a change occurs.
  • Mutation Level: The level at which a mutation occurs, including the nucleotide or amino acid level.
  • Mutation Type: The nature of the mutation, such as missense mutation, nonsense mutation, synonymous mutation, etc.
  • Gene/Protein/Region: Refers to the specific region of the virus where the mutation occurs. Including viral genes, viral proteins, or a specific viral genome region. If the article does not specifically indicate the relationship between the mutation and its correspondence, the main
  • Gene/Protein/Region studied in the article is marked.
  • Genotype/Subtype: Refers to the viral genotype or subtype where the mutation occurs. If the article does not specifically indicate the relationship between the mutation and its correspondence, the main Genotype/Subtype studied in the article is marked.
  • Viral Reference: Refers to the standard virus strain used to compare and analyze viral sequences.
Functional Impact and Mechanisms
  • Disease: An abnormal physiological state with specific symptoms and signs caused by viral infection.
  • Immune: The article focuses on the study of mutations and immune.
  • Target Gene: Host genes that viral mutations may affect.
Clinical and Epidemiological Correlations
  • Clinical Information: The study is a clinical or epidemiological study and provides basic information about the population.
  • Treatment: The study mentioned a certain treatment method, such as drug resistance caused by mutations. If the study does not specifically indicate the relationship between mutations and their correspondence treatment, the main treatment studied in the article is marked.
  • Location: The source of the research data.
Literature Information
  • Sequence Data: The study provides the data accession number.