SARS-CoV-2 Mutation Detail Information

Virus Mutation SARS-CoV-2 Mutation C26645T


Basic Characteristics of Mutations
Mutation Site C26645T
Mutation Site Sentence The C26645T mutation in the M-protein was associated with attending specific nightclub venues.
Mutation Level Nucleotide level
Mutation Type
Gene/Protein/Region M
Standardized Encoding Gene M  
Genotype/Subtype P.1.17.1
Viral Reference NC_045512.2
Functional Impact and Mechanisms
Disease COVID-19    
Immune -
Target Gene -
Clinical and Epidemiological Correlations
Clinical Information -
Treatment -
Location Luxembourg(Germany)
Literature Information
PMID 40133357
Title Nightlife and low immunity drove transmission of SARS-CoV-2 gamma in Luxembourg, 2021
Author Afonso YP,Bejko D,Ernst C,Huberty C,Wienecke-Baldacchino A,Berger S,Herold M,Walczak C,Ogorzaly L,Vergison A,Mossong J
Journal Scientific reports
Journal Info 2025 Mar 25;15(1):10293
Abstract In summer 2021, while the Delta variant was predominant in many European countries, Luxembourg experienced a large outbreak of the P.1.17.1 SARS-CoV-2 Gamma variant. This surge coincided with the introduction of digital COVID-19 certificates and eased restrictions prior to national holiday festivities. We investigated the molecular and epidemiological factors contributing to SARS-CoV-2 Gamma transmission. All laboratory SARS-CoV-2 confirmed cases were interviewed by contact tracing teams on exposures at nightlife venues, family gatherings, schools, and workplaces. Gamma sublineages were investigated through environmental wastewater surveillance, in addition to whole genome sequencing of clinical data. Infection clusters were analysed combining phylogenetic with epidemiological exposures. From June 22 to August 12, 2021, we identified 1,049 cases of the Gamma P.1.17.1 sublineage, representing 39.2% of all sequenced cases. Initially, nightlife was the most frequent source setting (49.1%) with young adults accounting for 92.3% of these cases. Later, transmission shifted towards family (30.4%) setting with a corresponding increase in the age distribution. The C26645T mutation in the M-protein was associated with attending specific nightclub venues. Notably, 96.8% of cases were in unvaccinated individuals, and while P.1.17.1 was also detected in neighboring countries, 75.6% of the sequences submitted to GISAID were from Luxembourg. The study suggests the role of nightlife and low population immunity in driving the summer surge of SARS-CoV-2 among young adults, with digital certificates showing minimal impact on transmission. Sequencing of clinical and wastewater samples in combination with contact tracing was crucial to inform the outbreak investigation.
Sequence Data -
Mutation Information
Note
Basic Characteristics of Mutations
  • Mutation Site: The specific location in a gene or protein sequence where a change occurs.
  • Mutation Level: The level at which a mutation occurs, including the nucleotide or amino acid level.
  • Mutation Type: The nature of the mutation, such as missense mutation, nonsense mutation, synonymous mutation, etc.
  • Gene/Protein/Region: Refers to the specific region of the virus where the mutation occurs. Including viral genes, viral proteins, or a specific viral genome region. If the article does not specifically indicate the relationship between the mutation and its correspondence, the main
  • Gene/Protein/Region studied in the article is marked.
  • Genotype/Subtype: Refers to the viral genotype or subtype where the mutation occurs. If the article does not specifically indicate the relationship between the mutation and its correspondence, the main Genotype/Subtype studied in the article is marked.
  • Viral Reference: Refers to the standard virus strain used to compare and analyze viral sequences.
Functional Impact and Mechanisms
  • Disease: An abnormal physiological state with specific symptoms and signs caused by viral infection.
  • Immune: The article focuses on the study of mutations and immune.
  • Target Gene: Host genes that viral mutations may affect.
Clinical and Epidemiological Correlations
  • Clinical Information: The study is a clinical or epidemiological study and provides basic information about the population.
  • Treatment: The study mentioned a certain treatment method, such as drug resistance caused by mutations. If the study does not specifically indicate the relationship between mutations and their correspondence treatment, the main treatment studied in the article is marked.
  • Location: The source of the research data.
Literature Information
  • Sequence Data: The study provides the data accession number.