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Basic Characteristics of Mutations
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Mutation Site
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D614G |
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Mutation Site Sentence
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SARS-CoV-2 spike D614G change enhances replication and transmission. |
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Mutation Level
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Amino acid level |
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Mutation Type
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Nonsynonymous substitution |
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Gene/Protein/Region
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S |
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Standardized Encoding Gene
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S
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Genotype/Subtype
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- |
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Viral Reference
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MT108784
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Functional Impact and Mechanisms
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Disease
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COVID-19
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Immune
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- |
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Target Gene
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-
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Clinical and Epidemiological Correlations
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Clinical Information
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- |
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Treatment
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- |
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Location
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- |
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Literature Information
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PMID
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33636719
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Title
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SARS-CoV-2 spike D614G change enhances replication and transmission
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Author
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Zhou B,Thao TTN,Hoffmann D,Taddeo A,Ebert N,Labroussaa F,Pohlmann A,King J,Steiner S,Kelly JN,Portmann J,Halwe NJ,Ulrich L,Trueb BS,Fan X,Hoffmann B,Wang L,Thomann L,Lin X,Stalder H,Pozzi B,de Brot S,Jiang N,Cui D,Hossain J,Wilson MM,Keller MW,Stark TJ,Barnes JR,Dijkman R,Jores J,Benarafa C,Wentworth DE,Thiel V,Beer M
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Journal
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Nature
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Journal Info
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2021 Apr;592(7852):122-127
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Abstract
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During the evolution of SARS-CoV-2 in humans, a D614G substitution in the spike glycoprotein (S) has emerged; virus containing this substitution has become the predominant circulating variant in the COVID-19 pandemic(1). However, whether the increasing prevalence of this variant reflects a fitness advantage that improves replication and/or transmission in humans or is merely due to founder effects remains unknown. Here we use isogenic SARS-CoV-2 variants to demonstrate that the variant that contains S(D614G) has enhanced binding to the human cell-surface receptor angiotensin-converting enzyme 2 (ACE2), increased replication in primary human bronchial and nasal airway epithelial cultures as well as in a human ACE2 knock-in mouse model, and markedly increased replication and transmissibility in hamster and ferret models of SARS-CoV-2 infection. Our data show that the D614G substitution in S results in subtle increases in binding and replication in vitro, and provides a real competitive advantage in vivo-particularly during the transmission bottleneck. Our data therefore provide an explanation for the global predominance of the variant that contains S(D614G) among the SARS-CoV-2 viruses that are currently circulating.
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Sequence Data
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PRJNA669553
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