HPV Mutation Detail Information

Virus Mutation HPV Mutation E113D


Basic Characteristics of Mutations
Mutation Site E113D
Mutation Site Sentence Six single-nucleotide variants were detected in the E6 gene of HPV16: G176A (D25N), T178G (D25E), C335T (H78Y), T350G (L83V), A442C (E113D), and A131C (R10R).
Mutation Level Amino acid level
Mutation Type Nonsynonymous substitution
Gene/Protein/Region E6
Standardized Encoding Gene E6
Genotype/Subtype HPV16
Viral Reference -
Functional Impact and Mechanisms
Disease Squamous Intraepithelial Lesions    
Immune -
Target Gene -
Clinical and Epidemiological Correlations
Clinical Information Y
Treatment -
Location China
Literature Information
PMID 31933750
Title Variant sublineages of human papillomavirus type 16 predispose women to persistent infection characterized by a sequence analysis of the E6, L1, and LCR regions
Author Yang B,Zhang L,Zhang A,Zhou A,Yuan J,Wang Y,Sun L,Cao H,Zheng W
Journal International journal of clinical and experimental pathology
Journal Info 2019 Jan 1;12(1):337-343
Abstract BACKGROUND: One of the precursors of cervical cancer is persistent infection with human papillomavirus (HPV), especially high-risk HPV. The aim of this study was to verify the relationship between HPV16 variants and persistent viral infection. METHODS: Three-hundred and eighty-six Chinese women who had a low-grade squamous intraepithelial lesion (LSIL) or a lesion below LSIL with normal cellular morphology were selected and enrolled in this study. Flow-through hybridization and gene chip technology were applied to identify the HPV type, and a PCR-sequencing assay was performed to detect HPV16 E6, L1, and long control region (LCR) gene variants. The relationship between HPV16 variants and persistent infection was analyzed using Fisher's exact test. RESULTS: In this population, 74.09% of HPV16 isolates belonged to the A4 sublineage, 24.87% to the A1/A2 sublineages, and 3.13% to B1/B2 sublineages. In addition, the A4 sublineage T178G (P<0.001) and the A1/A2 sublineages T350G and A442C (P<0.001) were associated with persistent HPV16 infection. L1 and LCR variants were found to be common in this population. Nonetheless, no significant relation was identified between the L1 or LCR variants and the persistence of infection (P>0.05). CONCLUSION: HPV16 E6 variants in the Shanghai Pudong District mainly belong to the A4 sublineage, and detection of the specific HPV E6 T178G genotype may be considered a risk factor for viral persistence and progression to other cervical diseases.
Sequence Data -
Mutation Information
Note
Basic Characteristics of Mutations
  • Mutation Site: The specific location in a gene or protein sequence where a change occurs.
  • Mutation Level: The level at which a mutation occurs, including the nucleotide or amino acid level.
  • Mutation Type: The nature of the mutation, such as missense mutation, nonsense mutation, synonymous mutation, etc.
  • Gene/Protein/Region: Refers to the specific region of the virus where the mutation occurs. Including viral genes, viral proteins, or a specific viral genome region. If the article does not specifically indicate the relationship between the mutation and its correspondence, the main
  • Gene/Protein/Region studied in the article is marked.
  • Genotype/Subtype: Refers to the viral genotype or subtype where the mutation occurs. If the article does not specifically indicate the relationship between the mutation and its correspondence, the main Genotype/Subtype studied in the article is marked.
  • Viral Reference: Refers to the standard virus strain used to compare and analyze viral sequences.
Functional Impact and Mechanisms
  • Disease: An abnormal physiological state with specific symptoms and signs caused by viral infection.
  • Immune: The article focuses on the study of mutations and immune.
  • Target Gene: Host genes that viral mutations may affect.
Clinical and Epidemiological Correlations
  • Clinical Information: The study is a clinical or epidemiological study and provides basic information about the population.
  • Treatment: The study mentioned a certain treatment method, such as drug resistance caused by mutations. If the study does not specifically indicate the relationship between mutations and their correspondence treatment, the main treatment studied in the article is marked.
  • Location: The source of the research data.
Literature Information
  • Sequence Data: The study provides the data accession number.