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Basic Characteristics of Mutations
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Mutation Site
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E484D |
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Mutation Site Sentence
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Remarkably,H522 infection requires the E484D S variant;viruses expressing wild-type S are not infectious. |
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Mutation Level
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Amino acid level |
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Mutation Type
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Nonsynonymous substitution |
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Gene/Protein/Region
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S |
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Standardized Encoding Gene
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S
|
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Genotype/Subtype
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- |
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Viral Reference
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NC_045512.2
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Functional Impact and Mechanisms
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Disease
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Cell line
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Immune
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- |
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Target Gene
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-
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Clinical and Epidemiological Correlations
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Clinical Information
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- |
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Treatment
|
- |
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Location
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- |
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Literature Information
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PMID
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34214467
|
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Title
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Systematic analysis of SARS-CoV-2 infection of an ACE2-negative human airway cell
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Author
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Puray-Chavez M,LaPak KM,Schrank TP,Elliott JL,Bhatt DP,Agajanian MJ,Jasuja R,Lawson DQ,Davis K,Rothlauf PW,Liu Z,Jo H,Lee N,Tenneti K,Eschbach JE,Shema Mugisha C,Cousins EM,Cloer EW,Vuong HR,VanBlargan LA,Bailey AL,Gilchuk P,Crowe JE Jr,Diamond MS,Hayes DN,Whelan SPJ,Horani A,Brody SL,Goldfarb D,Major MB,Kutluay SB
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Journal
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Cell reports
|
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Journal Info
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2021 Jul 13;36(2):109364
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Abstract
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Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) variants govern transmissibility, responsiveness to vaccination, and disease severity. In a screen for new models of SARS-CoV-2 infection, we identify human H522 lung adenocarcinoma cells as naturally permissive to SARS-CoV-2 infection despite complete absence of angiotensin-converting enzyme 2 (ACE2) expression. Remarkably, H522 infection requires the E484D S variant; viruses expressing wild-type S are not infectious. Anti-S monoclonal antibodies differentially neutralize SARS-CoV-2 E484D S in H522 cells as compared to ACE2-expressing cells. Sera from vaccinated individuals block this alternative entry mechanism, whereas convalescent sera are less effective. Although the H522 receptor remains unknown, depletion of surface heparan sulfates block H522 infection. Temporally resolved transcriptomic and proteomic profiling reveal alterations in cell cycle and the antiviral host cell response, including MDA5-dependent activation of type I interferon signaling. These findings establish an alternative SARS-CoV-2 host cell receptor for the E484D SARS-CoV-2 variant, which may impact tropism of SARS-CoV-2 and consequently human disease pathogenesis.
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Sequence Data
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GSE163547
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