SARS-CoV-2 Mutation Detail Information

Virus Mutation SARS-CoV-2 Mutation E484Q


Basic Characteristics of Mutations
Mutation Site E484Q
Mutation Site Sentence More detailed analysis disclosed that the prevailing lineage in distribution is a novel identified lineage B.1.617 holding in common signature mutations D111D, G142D, L452R, E484Q, D614G, and P681R, in the spike protein, containing within the receptor-binding domain (RBD) [2, 3].
Mutation Level Amino acid level
Mutation Type Nonsynonymous substitution
Gene/Protein/Region S
Standardized Encoding Gene S  
Genotype/Subtype Delta
Viral Reference -
Functional Impact and Mechanisms
Disease COVID-19    
Immune -
Target Gene -
Clinical and Epidemiological Correlations
Clinical Information -
Treatment -
Location -
Literature Information
PMID 35075065
Title COVID-19 Delta variation; more contagious or more pernicious?
Author Yazdanpanah F,Yazdanpanah S,Rezaei N
Journal Acta bio-medica : Atenei Parmensis
Journal Info 2022 Jan 19;92(6):e2021454
Abstract To the editor, Among the advancement of the COVID-19 pandemic, the pathogenic virus proceeds to change genomic epidemiology and steadily whole-genome sequencing evolution. One of the latest variations, SARS-CoV-2 delta, B.1.617.2 variant of concern (VOC) formerly, has become the most prevalent type of SARS-CoV-2 in many countries [1]. It identified following an upsurge in the western part of India since January 2021. More detailed analysis disclosed that the prevailing lineage in distribution is a novel identified lineage B.1.617 holding in common signature mutations D111D, G142D, L452R, E484Q, D614G, and P681R, in the spike protein, containing within the receptor-binding domain (RBD) [2, 3]. Following the initial high mortality rate of this variation in India as its hostess, as the growing number of fatal reports from several countries regarding its transfer to most parts of world in recent months, Delta variation was known as the deadliest COVID-19 [4, 5, 6]. According to official statistics, the mortality rate in individuals in areas where the Delta variant has become dominant is much higher than the same period and the epidemic with previous COVID-19 lineages. The enigma here is, does this mean more lethality of this variant?
Sequence Data -
Mutation Information
Note
Basic Characteristics of Mutations
  • Mutation Site: The specific location in a gene or protein sequence where a change occurs.
  • Mutation Level: The level at which a mutation occurs, including the nucleotide or amino acid level.
  • Mutation Type: The nature of the mutation, such as missense mutation, nonsense mutation, synonymous mutation, etc.
  • Gene/Protein/Region: Refers to the specific region of the virus where the mutation occurs. Including viral genes, viral proteins, or a specific viral genome region. If the article does not specifically indicate the relationship between the mutation and its correspondence, the main
  • Gene/Protein/Region studied in the article is marked.
  • Genotype/Subtype: Refers to the viral genotype or subtype where the mutation occurs. If the article does not specifically indicate the relationship between the mutation and its correspondence, the main Genotype/Subtype studied in the article is marked.
  • Viral Reference: Refers to the standard virus strain used to compare and analyze viral sequences.
Functional Impact and Mechanisms
  • Disease: An abnormal physiological state with specific symptoms and signs caused by viral infection.
  • Immune: The article focuses on the study of mutations and immune.
  • Target Gene: Host genes that viral mutations may affect.
Clinical and Epidemiological Correlations
  • Clinical Information: The study is a clinical or epidemiological study and provides basic information about the population.
  • Treatment: The study mentioned a certain treatment method, such as drug resistance caused by mutations. If the study does not specifically indicate the relationship between mutations and their correspondence treatment, the main treatment studied in the article is marked.
  • Location: The source of the research data.
Literature Information
  • Sequence Data: The study provides the data accession number.