HBV Mutation Detail Information

Virus Mutation HBV Mutation G102S


Basic Characteristics of Mutations
Mutation Site G102S
Mutation Site Sentence Out of the 23 isolates, 15 (65%) exhibited single or multiple substitutions, which resulted to specific amino acid changes as follows: Tyrosine (Y) to Cysteine (C) at position 100, Glutamine (Q) to Lysine (K) at position 101, Glycine (G) to Serine (S) at position 102, Methionine (M) to Isoleucine (I) at position 103, Leucine (L) to Proline (P) at position 109, Isoleucine (I) to Leucine (L) at position 110, Leucine (L) to Isoleucine (I) at position 110, Threonine (T) to Serine (S) at position 113, Threonine (T) to Asparagine (N) at position 116, Serine (S) to Arginine (R) at position 117, Isoluecine (I) to Threonine (T) at position 126, Isoleucine (I) to Serine (S) at position 126, Proline (P) to Threonine (T) at position 127, Glycine (G) to Serine (S) at position 130, Methionine (M) to Threonine (T) at position 133, Phenylalanine (F) to Isoleucine (I) at position 134, Serine (S) to Leucine (L) at position 136, and Aspartic acid (D) to Alanine (A) at position 144 as shown in Figures 1-3.
Mutation Level Amino acid level
Mutation Type Nonsynonymous substitution
Gene/Protein/Region S
Standardized Encoding Gene S  
Genotype/Subtype -
Viral Reference Fig.1;Fig.2;Fig.3
Functional Impact and Mechanisms
Disease Hepatitis B, Chronic    
Immune -
Target Gene -
Clinical and Epidemiological Correlations
Clinical Information -
Treatment -
Location -
Literature Information
PMID 24009186
Title Unique surface gene variants of hepatitis B virus isolated from patients in the Philippines
Author Baclig MO,Alvarez MR,Gopez-Cervantes J,Natividad FF
Journal Journal of medical virology
Journal Info 2014 Feb;86(2):209-16
Abstract Point mutations and multiple variants across the ""a"" determinant can destroy the antigenicity and immunogenicity of hepatitis B virus (HBV) leading to false negative assay and vaccine escape. In this study, the presence of surface gene variants of HBV was investigated among patients clinically diagnosed with chronic hepatitis B and positive for HBV DNA from 2002 to 2009. Sequence analysis of the surface gene of HBV showed that 23 (43%) of the 53 isolates had variations. Out of the 23 isolates, 15 (65%) exhibited single or multiple substitutions, which resulted to specific amino acid changes. The remaining 8 (35%) isolates had silent mutations. The amino acid substitution M133T which was associated with failure of HBsAg detection was found in one isolate (7%, 1/15), while the amino acid substitution D144A which was associated with vaccine escape was observed in one isolate (7%, 1/15). No G145R mutation was observed. Of the 15 isolates with identified single or multiple substitutions, 6 (40%) were found to have unique sequences which caused changes in the hydrophobicity profile in the protein. Unique sequence variants at amino acid positions M103I, L109P, S117R, F134I, and S136L found in this study have not yet been reported. These data should be taken into account when developing next generation HBV assays to detect both common and unique variants, and when new HBV vaccines will be designed.
Sequence Data HM371272-HM371323;AEI70508-AEI70555
Mutation Information
Note
Basic Characteristics of Mutations
  • Mutation Site: The specific location in a gene or protein sequence where a change occurs.
  • Mutation Level: The level at which a mutation occurs, including the nucleotide or amino acid level.
  • Mutation Type: The nature of the mutation, such as missense mutation, nonsense mutation, synonymous mutation, etc.
  • Gene/Protein/Region: Refers to the specific region of the virus where the mutation occurs. Including viral genes, viral proteins, or a specific viral genome region. If the article does not specifically indicate the relationship between the mutation and its correspondence, the main
  • Gene/Protein/Region studied in the article is marked.
  • Genotype/Subtype: Refers to the viral genotype or subtype where the mutation occurs. If the article does not specifically indicate the relationship between the mutation and its correspondence, the main Genotype/Subtype studied in the article is marked.
  • Viral Reference: Refers to the standard virus strain used to compare and analyze viral sequences.
Functional Impact and Mechanisms
  • Disease: An abnormal physiological state with specific symptoms and signs caused by viral infection.
  • Immune: The article focuses on the study of mutations and immune.
  • Target Gene: Host genes that viral mutations may affect.
Clinical and Epidemiological Correlations
  • Clinical Information: The study is a clinical or epidemiological study and provides basic information about the population.
  • Treatment: The study mentioned a certain treatment method, such as drug resistance caused by mutations. If the study does not specifically indicate the relationship between mutations and their correspondence treatment, the main treatment studied in the article is marked.
  • Location: The source of the research data.
Literature Information
  • Sequence Data: The study provides the data accession number.