HBV Mutation Detail Information

Virus Mutation HBV Mutation G145K


Basic Characteristics of Mutations
Mutation Site G145K
Mutation Site Sentence The classical immune escape mutations sG145A/K were found in both anti-HBs (+) and anti-HBs (-) OBIC strains with low mutation frequency, suggesting that this classical mutation might be better detected due to the improvement in HBsAg detection reagents, and the mutation may occur randomly regardless of the pressure of anti-HBs.
Mutation Level Amino acid level
Mutation Type Nonsynonymous substitution
Gene/Protein/Region S
Standardized Encoding Gene S  
Genotype/Subtype B;C
Viral Reference FJ386582;FJ386600;FJ386608;FJ386610;FJ386634;FJ386654;FJ386655;FJ386658;FJ386668;FJ386669;FJ386680;FJ386681;FJ386683;FJ386684;FJ386688;FJ386577;FJ386579;FJ386585;FJ386587;FJ386603;FJ386604;FJ386614;FJ386619;FJ386639;FJ386644;FJ386649;FJ386657;FJ386661;FJ386662;FJ386685.
Functional Impact and Mechanisms
Disease Occult HBV Infection    
Immune Y
Target Gene -
Clinical and Epidemiological Correlations
Clinical Information -
Treatment -
Location China
Literature Information
PMID 35903154
Title The Investigation of HBV Pre-S/S Gene Mutations in Occult HBV Infected Blood Donors with anti-HBs Positive
Author Guo Y,Lan Y,Jing Y,Cai B,Gong H,Zhang Y,Duan Y
Journal The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale
Journal Info 2022 Jul 19;2022:1874435
Abstract INTRODUCTION: The coexistence of hepatitis B virus (HBV) and hepatitis B surface antibodies (anti-HBs) in occult hepatitis B virus infection (OBI) is a contradictory phenomenon, and the underlying mechanism is not fully understood. The characteristics of pre-S/S mutations in OBI genotypes B and C (OBI(B) and OBI(C)) in the presence or absence of anti-HBs were analyzed extensively in this study. Methodology. The amino acid substitutions of envelope proteins of 21 OBI strains, including 4 HBs (+) OBI(B), 6 HBs (-) OBI(B), 6 HBs (+) OBIc, and 5 HBs (-) OBI(C) samples, were analyzed and fully compared among groups of HBV genotypes and the presence of anti-HBs. RESULTS: The mutation rates in pre-S1, pre-S2, and S proteins of OBI(C) were significantly higher than wild-type HBV (wt-HBV) genotype C strains, but only the mutation rate of S protein in OBI(B) was significantly higher compared to wild-type HBV genotype B. The mutation rates in S protein of anti-HBs (-) OBI were higher than anti-HBs(+) OBI samples (4.40% vs. 2.43% in genotype B, P > 0.05; 6.81% vs. 3.47% in genotype C, P < 0.05). For these high-frequency substitutions in the pre-S/S region, the mutations sN40S and sK122R were found in 27.3% and 45.5% of anti-HBs (-) OBI strains, respectively. 7 substitutions were uniquely found in OBI(C) strains and 9 substitutions were commonly detected in OBI(B) and OBI(C) strains. CONCLUSIONS: These results suggested that the mutations might occur randomly and were not selected by antibody pressure.
Sequence Data -
Mutation Information
Note
Basic Characteristics of Mutations
  • Mutation Site: The specific location in a gene or protein sequence where a change occurs.
  • Mutation Level: The level at which a mutation occurs, including the nucleotide or amino acid level.
  • Mutation Type: The nature of the mutation, such as missense mutation, nonsense mutation, synonymous mutation, etc.
  • Gene/Protein/Region: Refers to the specific region of the virus where the mutation occurs. Including viral genes, viral proteins, or a specific viral genome region. If the article does not specifically indicate the relationship between the mutation and its correspondence, the main
  • Gene/Protein/Region studied in the article is marked.
  • Genotype/Subtype: Refers to the viral genotype or subtype where the mutation occurs. If the article does not specifically indicate the relationship between the mutation and its correspondence, the main Genotype/Subtype studied in the article is marked.
  • Viral Reference: Refers to the standard virus strain used to compare and analyze viral sequences.
Functional Impact and Mechanisms
  • Disease: An abnormal physiological state with specific symptoms and signs caused by viral infection.
  • Immune: The article focuses on the study of mutations and immune.
  • Target Gene: Host genes that viral mutations may affect.
Clinical and Epidemiological Correlations
  • Clinical Information: The study is a clinical or epidemiological study and provides basic information about the population.
  • Treatment: The study mentioned a certain treatment method, such as drug resistance caused by mutations. If the study does not specifically indicate the relationship between mutations and their correspondence treatment, the main treatment studied in the article is marked.
  • Location: The source of the research data.
Literature Information
  • Sequence Data: The study provides the data accession number.