HBV Mutation Detail Information

Virus Mutation HBV Mutation G145R


Basic Characteristics of Mutations
Mutation Site G145R
Mutation Site Sentence The G145R mutant is replication competent and is stable, and it appears to be the most common variant.
Mutation Level Amino acid level
Mutation Type Nonsynonymous substitution
Gene/Protein/Region S
Standardized Encoding Gene S  
Genotype/Subtype -
Viral Reference -
Functional Impact and Mechanisms
Disease Hepatitis B Virus Infection    
Immune -
Target Gene -
Clinical and Epidemiological Correlations
Clinical Information -
Treatment -
Location -
Literature Information
PMID 14638401
Title Mutations of the surface protein of hepatitis B virus
Author Zuckerman JN,Zuckerman AJ
Journal Antiviral research
Journal Info 2003 Oct;60(2):75-8
Abstract Neutralizing antibodies induced by immunization against hepatitis B infection are targeted to the conformational epitopes of the common a determinant of the surface antigen. However, amino acid substitutions within this region of the surface protein of the virus, particularly in the region of amino acid 137-147 allow replication of hepatitis B virus in vaccinated subjects, since antibodies induced by current vaccines do not recognize crucial changes in the surface antigen domain. The G145R mutant is replication competent and is stable, and it appears to be the most common variant. There is evidence that these mutants may not be detected by current screening tests and diagnostic reagents. Epidemiological monitoring of hepatitis B virus surface mutants is essential.
Sequence Data -
Mutation Information
Note
Basic Characteristics of Mutations
  • Mutation Site: The specific location in a gene or protein sequence where a change occurs.
  • Mutation Level: The level at which a mutation occurs, including the nucleotide or amino acid level.
  • Mutation Type: The nature of the mutation, such as missense mutation, nonsense mutation, synonymous mutation, etc.
  • Gene/Protein/Region: Refers to the specific region of the virus where the mutation occurs. Including viral genes, viral proteins, or a specific viral genome region. If the article does not specifically indicate the relationship between the mutation and its correspondence, the main
  • Gene/Protein/Region studied in the article is marked.
  • Genotype/Subtype: Refers to the viral genotype or subtype where the mutation occurs. If the article does not specifically indicate the relationship between the mutation and its correspondence, the main Genotype/Subtype studied in the article is marked.
  • Viral Reference: Refers to the standard virus strain used to compare and analyze viral sequences.
Functional Impact and Mechanisms
  • Disease: An abnormal physiological state with specific symptoms and signs caused by viral infection.
  • Immune: The article focuses on the study of mutations and immune.
  • Target Gene: Host genes that viral mutations may affect.
Clinical and Epidemiological Correlations
  • Clinical Information: The study is a clinical or epidemiological study and provides basic information about the population.
  • Treatment: The study mentioned a certain treatment method, such as drug resistance caused by mutations. If the study does not specifically indicate the relationship between mutations and their correspondence treatment, the main treatment studied in the article is marked.
  • Location: The source of the research data.
Literature Information
  • Sequence Data: The study provides the data accession number.