EBV Mutation Detail Information

Virus Mutation EBV Mutation G162852T


Basic Characteristics of Mutations
Mutation Site G162852T
Mutation Site Sentence The three SNPs 162507C>T, 162852G>T and 162215C>A reaching genome-wide significance are labeled as green.
Mutation Level Nucleotide level
Mutation Type
Gene/Protein/Region BALF2
Standardized Encoding Gene BALF2  
Genotype/Subtype -
Viral Reference NC007605.1
Functional Impact and Mechanisms
Disease Nasopharyngeal Carcinoma    
Immune -
Target Gene -
Clinical and Epidemiological Correlations
Clinical Information -
Treatment -
Location China
Literature Information
PMID 31209392
Title Genome sequencing analysis identifies Epstein-Barr virus subtypes associated with high risk of nasopharyngeal carcinoma
Author Xu M,Yao Y,Chen H,Zhang S,Cao SM,Zhang Z,Luo B,Liu Z,Li Z,Xiang T,He G,Feng QS,Chen LZ,Guo X,Jia WH,Chen MY,Zhang X,Xie SH,Peng R,Chang ET,Pedergnana V,Feng L,Bei JX,Xu RH,Zeng MS,Ye W,Adami HO,Lin X,Zhai W,Zeng YX,Liu J
Journal Nature genetics
Journal Info 2019 Jul;51(7):1131-1136
Abstract Epstein-Barr virus (EBV) infection is ubiquitous worldwide and is associated with multiple cancers, including nasopharyngeal carcinoma (NPC). The importance of EBV viral genomic variation in NPC development and its striking epidemic in southern China has been poorly explored. Through large-scale genome sequencing of 270 EBV isolates and two-stage association study of EBV isolates from China, we identify two non-synonymous EBV variants within BALF2 that are strongly associated with the risk of NPC (odds ratio (OR) = 8.69, P = 9.69 x 10(-25) for SNP 162476_C; OR = 6.14, P = 2.40 x 10(-32) for SNP 163364_T). The cumulative effects of these variants contribute to 83% of the overall risk of NPC in southern China. Phylogenetic analysis of the risk variants reveals a unique origin in Asia, followed by clonal expansion in NPC-endemic regions. Our results provide novel insights into the NPC endemic in southern China and also enable the identification of high-risk individuals for NPC prevention.
Sequence Data MK540241-MK540470
Mutation Information
Note
Basic Characteristics of Mutations
  • Mutation Site: The specific location in a gene or protein sequence where a change occurs.
  • Mutation Level: The level at which a mutation occurs, including the nucleotide or amino acid level.
  • Mutation Type: The nature of the mutation, such as missense mutation, nonsense mutation, synonymous mutation, etc.
  • Gene/Protein/Region: Refers to the specific region of the virus where the mutation occurs. Including viral genes, viral proteins, or a specific viral genome region. If the article does not specifically indicate the relationship between the mutation and its correspondence, the main
  • Gene/Protein/Region studied in the article is marked.
  • Genotype/Subtype: Refers to the viral genotype or subtype where the mutation occurs. If the article does not specifically indicate the relationship between the mutation and its correspondence, the main Genotype/Subtype studied in the article is marked.
  • Viral Reference: Refers to the standard virus strain used to compare and analyze viral sequences.
Functional Impact and Mechanisms
  • Disease: An abnormal physiological state with specific symptoms and signs caused by viral infection.
  • Immune: The article focuses on the study of mutations and immune.
  • Target Gene: Host genes that viral mutations may affect.
Clinical and Epidemiological Correlations
  • Clinical Information: The study is a clinical or epidemiological study and provides basic information about the population.
  • Treatment: The study mentioned a certain treatment method, such as drug resistance caused by mutations. If the study does not specifically indicate the relationship between mutations and their correspondence treatment, the main treatment studied in the article is marked.
  • Location: The source of the research data.
Literature Information
  • Sequence Data: The study provides the data accession number.