HPV Mutation Detail Information

Virus Mutation HPV Mutation G274T


Basic Characteristics of Mutations
Mutation Site G274T
Mutation Site Sentence Among the remaining 31 variants, variants with the T350G nucleotide change were predominant (13/31, 42%), followed by variants containing G94A (11/31, 35%), G176A (4/31, 13%) and G274T (2/31, 7%).
Mutation Level Nucleotide level
Mutation Type Nonsynonymous substitution
Gene/Protein/Region E6
Standardized Encoding Gene E6
Genotype/Subtype HPV16
Viral Reference K02718
Functional Impact and Mechanisms
Disease Cervical Intraepithelial Neoplasia     Uterine Cervical Neoplasms    
Immune -
Target Gene -
Clinical and Epidemiological Correlations
Clinical Information Y
Treatment -
Location Mongolia
Literature Information
PMID 19256739
Title Distribution of HPV-16 intratypic variants among women with cervical intraepithelial neoplasia and invasive cervical cancer in Mongolia
Author Chimeddorj B,Pak CY,Damdin A,Okamoto N,Miyagi Y
Journal Asian Pacific journal of cancer prevention : APJCP
Journal Info 2008 Oct-Dec;9(4):563-8
Abstract OBJECTIVES: Infection with high-risk human papillomavirus (HPV) is a critical factor associated with carcinogenesis of the uterine cervix. HPV-16 is most frequently found, and is further subclassified into intratypic variants based on the nucleotide sequences of the viral genes. Although certain HPV-16 variants are reported to be associated with the progression of cervical lesions, these relationships remain controversial with different results for different populations. To provide data for another population, we investigated the prevalence of HPV-16 and distributions of its intratypic variants among Mongolian women with cervical intraepithelial neoplasia (CIN) and invasive cervical cancer. MATERIALS AND METHODS: We analyzed samples from 374 randomly selected women who attended the National Cancer Center of Mongolia between January 2002 and July 2007, including 147 invasive cervical cancer patients, 127 CIN patients and 100 age-matched controls who were cytologically normal. HPV genotyping was initially conducted, followed by variant analysis for HPV-16-positive samples by nucleotide sequencing of the E6 gene. The HPV data were evaluated statistically for correlations with the patients' clinical data. RESULTS: HPV genotyping detected 101 HPV-16-positive samples. Among these samples, 92 were available for subsequent variant analysis, including 66 invasive cervical cancer samples, 25 CIN samples and 1 cytologically normal sample. A total of 14 different variants were identified. All 14 variants belonged to the European lineage, and the European prototype was detected in 66% (61/92) of the samples. Among the remaining 31 variants, variants with the T350G nucleotide change were predominant (13/31, 42%), followed by variants containing G94A (11/31, 35%), G176A (4/31, 13%) and G274T (2/31, 7%). There were no significant differences among all the variants regarding their distributions in CIN and invasive cervical cancers. CONCLUSIONS: HPV-16 variants of the European lineage were exclusively distributed among the Mongolian women examined, and the European prototype was overwhelmingly predominant. Since no significant differences were found between the types of variants and severities of the cervical lesions, it is possible that racial or geographic factors may have some influences on these relationships.
Sequence Data -
Mutation Information
Note
Basic Characteristics of Mutations
  • Mutation Site: The specific location in a gene or protein sequence where a change occurs.
  • Mutation Level: The level at which a mutation occurs, including the nucleotide or amino acid level.
  • Mutation Type: The nature of the mutation, such as missense mutation, nonsense mutation, synonymous mutation, etc.
  • Gene/Protein/Region: Refers to the specific region of the virus where the mutation occurs. Including viral genes, viral proteins, or a specific viral genome region. If the article does not specifically indicate the relationship between the mutation and its correspondence, the main
  • Gene/Protein/Region studied in the article is marked.
  • Genotype/Subtype: Refers to the viral genotype or subtype where the mutation occurs. If the article does not specifically indicate the relationship between the mutation and its correspondence, the main Genotype/Subtype studied in the article is marked.
  • Viral Reference: Refers to the standard virus strain used to compare and analyze viral sequences.
Functional Impact and Mechanisms
  • Disease: An abnormal physiological state with specific symptoms and signs caused by viral infection.
  • Immune: The article focuses on the study of mutations and immune.
  • Target Gene: Host genes that viral mutations may affect.
Clinical and Epidemiological Correlations
  • Clinical Information: The study is a clinical or epidemiological study and provides basic information about the population.
  • Treatment: The study mentioned a certain treatment method, such as drug resistance caused by mutations. If the study does not specifically indicate the relationship between mutations and their correspondence treatment, the main treatment studied in the article is marked.
  • Location: The source of the research data.
Literature Information
  • Sequence Data: The study provides the data accession number.