HTLV1 Mutation Detail Information

Virus Mutation HTLV1 Mutation G434A


Basic Characteristics of Mutations
Mutation Site G434A
Mutation Site Sentence Table 1
Mutation Level Nucleotide level
Mutation Type Nonsynonymous substitution
Gene/Protein/Region HBZ
Standardized Encoding Gene pX
Genotype/Subtype -
Viral Reference J02029.1
Functional Impact and Mechanisms
Disease HTLV-1 Infection     Paraparesis, Tropical Spastic    
Immune -
Target Gene -
Clinical and Epidemiological Correlations
Clinical Information -
Treatment -
Location Brazil
Literature Information
PMID 33835501
Title Molecular characterization of HTLV-1 genomic region hbz from patients with different clinical conditions
Author Cucco MS,de Moraes LEP,de Oliveira Andrade F,Khouri R,Galvao-Castro B,Araujo THA,de Almeida Rego FF,Gois LL,Barreto FK,Santos LA
Journal Journal of medical virology
Journal Info 2021 Nov;93(11):6418-6423
Abstract The human T-cell lymphotropic virus type-1 (HTLV-1) is associated with severe pathologies, such as HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP), adult T-cell leukemia-lymphoma (ATLL), and infective dermatitis associated with the HTLV-1 (IDH). Interestingly, HTLV-1 infection does not necessarily imply the development of pathological processes and it is unknown why some patients remain asymptomatic carriers (AC). Despite some mutations in the HTLV-1 genome appear to influence the outcome of HTLV-1, there are few studies that characterize molecularly the hbz region. This study aimed to perform the molecular characterization of hbz gene isolated from patients with different clinical outcomes. A total of 15 sequences were generated and analyzed with 571 sequences previously published. The analises showed that the R119Q mutation seems to be related to HTLV-1 clinical conditions since the frequency of this HBZ mutation is significantly different in comparison between AC with HAM/TSP and ATLL. The R119Q mutation is possibly a protective factor as the frequency is higher in AC sequences.
Sequence Data MW288041-MW288055;AB127436-AB127579; AB154777-AB154817; AB158146-AB158191;AB158266-AB158276; AB513134; AF042071; AY780366-AY780391;DQ065781-DQ065794;KF053876-KF053885;KF797897;KF797907;KF797910;KF797912;KM436104-KM437632; KU214243;KY007244-KY007274; L36905;LC192500-LC192536;M37301;MF158987-MF159019;MH392265;MH395864;MH399767-MH399769; MN781149; MN781150; MN781152-MN781156;U19949
Mutation Information
Note
Basic Characteristics of Mutations
  • Mutation Site: The specific location in a gene or protein sequence where a change occurs.
  • Mutation Level: The level at which a mutation occurs, including the nucleotide or amino acid level.
  • Mutation Type: The nature of the mutation, such as missense mutation, nonsense mutation, synonymous mutation, etc.
  • Gene/Protein/Region: Refers to the specific region of the virus where the mutation occurs. Including viral genes, viral proteins, or a specific viral genome region. If the article does not specifically indicate the relationship between the mutation and its correspondence, the main
  • Gene/Protein/Region studied in the article is marked.
  • Genotype/Subtype: Refers to the viral genotype or subtype where the mutation occurs. If the article does not specifically indicate the relationship between the mutation and its correspondence, the main Genotype/Subtype studied in the article is marked.
  • Viral Reference: Refers to the standard virus strain used to compare and analyze viral sequences.
Functional Impact and Mechanisms
  • Disease: An abnormal physiological state with specific symptoms and signs caused by viral infection.
  • Immune: The article focuses on the study of mutations and immune.
  • Target Gene: Host genes that viral mutations may affect.
Clinical and Epidemiological Correlations
  • Clinical Information: The study is a clinical or epidemiological study and provides basic information about the population.
  • Treatment: The study mentioned a certain treatment method, such as drug resistance caused by mutations. If the study does not specifically indicate the relationship between mutations and their correspondence treatment, the main treatment studied in the article is marked.
  • Location: The source of the research data.
Literature Information
  • Sequence Data: The study provides the data accession number.