VZV Mutation Detail Information

Virus Mutation VZV Mutation G448A


Basic Characteristics of Mutations
Mutation Site G448A
Mutation Site Sentence The VZV-BC and VZV-MSP strains differed from the prototype Dumas VZV strain (GenBank accession no. X04370) in ORF68 by a single G448A nucleotide mutation (D150N amino acid substitution) in the 3B3 epitope of gE (Table).
Mutation Level Nucleotide level
Mutation Type Nonsynonymous substitution
Gene/Protein/Region gE
Standardized Encoding Gene ORF68  
Genotype/Subtype -
Viral Reference X04370
Functional Impact and Mechanisms
Disease Herpes zoster    
Immune Y
Target Gene -
Clinical and Epidemiological Correlations
Clinical Information Y
Treatment -
Location Canada
Literature Information
PMID 12498673
Title New variant of varicella-zoster virus
Author Tipples GA,Stephens GM,Sherlock C,Bowler M,Hoy B,Cook D,Grose C
Journal Emerging infectious diseases
Journal Info 2002 Dec;8(12):1504-5
Abstract In 1998, a varicella-zoster virus glycoprotein E (gE) mutant virus (VZV-MSP) was isolated from a child with chickenpox. VZV-MSP, representing a second VZV serotype, was considered a rarity. We isolated another VZV-MSP-like virus from an elderly man with herpes zoster. These gE mutant viruses may have arisen through independent mutation or may represent a distinct VZV subpopulation that emerged more than 50 years ago.
Sequence Data AY005330
Mutation Information
Note
Basic Characteristics of Mutations
  • Mutation Site: The specific location in a gene or protein sequence where a change occurs.
  • Mutation Level: The level at which a mutation occurs, including the nucleotide or amino acid level.
  • Mutation Type: The nature of the mutation, such as missense mutation, nonsense mutation, synonymous mutation, etc.
  • Gene/Protein/Region: Refers to the specific region of the virus where the mutation occurs. Including viral genes, viral proteins, or a specific viral genome region. If the article does not specifically indicate the relationship between the mutation and its correspondence, the main
  • Gene/Protein/Region studied in the article is marked.
  • Genotype/Subtype: Refers to the viral genotype or subtype where the mutation occurs. If the article does not specifically indicate the relationship between the mutation and its correspondence, the main Genotype/Subtype studied in the article is marked.
  • Viral Reference: Refers to the standard virus strain used to compare and analyze viral sequences.
Functional Impact and Mechanisms
  • Disease: An abnormal physiological state with specific symptoms and signs caused by viral infection.
  • Immune: The article focuses on the study of mutations and immune.
  • Target Gene: Host genes that viral mutations may affect.
Clinical and Epidemiological Correlations
  • Clinical Information: The study is a clinical or epidemiological study and provides basic information about the population.
  • Treatment: The study mentioned a certain treatment method, such as drug resistance caused by mutations. If the study does not specifically indicate the relationship between mutations and their correspondence treatment, the main treatment studied in the article is marked.
  • Location: The source of the research data.
Literature Information
  • Sequence Data: The study provides the data accession number.