HEV Mutation Detail Information

Virus Mutation HEV Mutation G490N


Basic Characteristics of Mutations
Mutation Site G490N
Mutation Site Sentence On the other hands, the HEV3c ORF2 autochthonous strain carried the following substitutions: E435D, S483T, G490N, V492M, S497T, L500F, T517S, S527T, T529I.
Mutation Level Amino acid level
Mutation Type Nonsynonymous substitution
Gene/Protein/Region ORF2
Standardized Encoding Gene ORF2
Genotype/Subtype Genotype 3c
Viral Reference FJ705359.1
Functional Impact and Mechanisms
Disease HEV Infection    
Immune -
Target Gene -
Clinical and Epidemiological Correlations
Clinical Information Y
Treatment -
Location Italy
Literature Information
PMID 40132339
Title Molecular characterization of autochthonous Hepatitis E virus detected from a human acute infection in the Calabria Region, Southern Italy
Author Marascio N,Pantanella M,Pavia G,Mazzei C,Di Salvo S,Trimboli F,Barreca GS,Lamberti AG,De Siena M,Gravina T,Matera G,Quirino A
Journal Diagnostic microbiology and infectious disease
Journal Info 2025 Jul;112(3):116807
Abstract Herein, we reported the molecular characterization of HEV autochthonous strain from an immunocompetent patient. The HEV was classified as subtype 3c and displayed the V1479I ribavirin resistance mutation. The phylogenetic tree analysis showed two statistically supported clusters, including viral strains from symptomatic patients, without severe disease, and meat products.
Sequence Data -
Mutation Information
Note
Basic Characteristics of Mutations
  • Mutation Site: The specific location in a gene or protein sequence where a change occurs.
  • Mutation Level: The level at which a mutation occurs, including the nucleotide or amino acid level.
  • Mutation Type: The nature of the mutation, such as missense mutation, nonsense mutation, synonymous mutation, etc.
  • Gene/Protein/Region: Refers to the specific region of the virus where the mutation occurs. Including viral genes, viral proteins, or a specific viral genome region. If the article does not specifically indicate the relationship between the mutation and its correspondence, the main
  • Gene/Protein/Region studied in the article is marked.
  • Genotype/Subtype: Refers to the viral genotype or subtype where the mutation occurs. If the article does not specifically indicate the relationship between the mutation and its correspondence, the main Genotype/Subtype studied in the article is marked.
  • Viral Reference: Refers to the standard virus strain used to compare and analyze viral sequences.
Functional Impact and Mechanisms
  • Disease: An abnormal physiological state with specific symptoms and signs caused by viral infection.
  • Immune: The article focuses on the study of mutations and immune.
  • Target Gene: Host genes that viral mutations may affect.
Clinical and Epidemiological Correlations
  • Clinical Information: The study is a clinical or epidemiological study and provides basic information about the population.
  • Treatment: The study mentioned a certain treatment method, such as drug resistance caused by mutations. If the study does not specifically indicate the relationship between mutations and their correspondence treatment, the main treatment studied in the article is marked.
  • Location: The source of the research data.
Literature Information
  • Sequence Data: The study provides the data accession number.