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Basic Characteristics of Mutations
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Mutation Site
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G53D |
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Mutation Site Sentence
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A Non-structural 1 Protein G53D Substitution Attenuates a Clinically Tested Live Dengue Vaccine |
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Mutation Level
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Amino acid level |
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Mutation Type
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Nonsynonymous substitution |
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Gene/Protein/Region
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NS1 |
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Standardized Encoding Gene
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NS1
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Genotype/Subtype
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DENV-2 |
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Viral Reference
|
KU725663
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Functional Impact and Mechanisms
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Disease
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Cell line
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Immune
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- |
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Target Gene
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-
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Clinical and Epidemiological Correlations
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Clinical Information
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- |
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Treatment
|
- |
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Location
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- |
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Literature Information
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PMID
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32402284
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Title
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A Non-structural 1 Protein G53D Substitution Attenuates a Clinically Tested Live Dengue Vaccine
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Author
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Choy MM,Ng DHL,Siriphanitchakorn T,Ng WC,Sundstrom KB,Tan HC,Zhang SL,Chan KWK,Manuel M,Kini RM,Chan KR,Vasudevan SG,Ooi EE
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Journal
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Cell reports
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Journal Info
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2020 May 12;31(6):107617
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Abstract
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The molecular basis of dengue virus (DENV) attenuation remains ambiguous and hampers a targeted approach to derive safe but nonetheless immunogenic live vaccine candidates. Here, we take advantage of DENV serotype 2 PDK53 vaccine strain, which recently and successfully completed a phase-3 clinical trial, to identify how this virus is attenuated compared to its wild-type parent, DENV2 16681. Site-directed mutagenesis on a 16681 infectious clone identifies a single G53D substitution in the non-structural 1 (NS1) protein that reduces 16681 infection and dissemination in both Aedes aegypti, as well as in mammalian cells to produce the characteristic phenotypes of PDK53. Mechanistically, NS1 G53D impairs the function of a known host factor, the endoplasmic reticulum (ER)-resident ribophorin 1 protein, to properly glycosylate NS1 and thus induce a host antiviral gene through ER stress responses. Our findings provide molecular insights on DENV attenuation on a clinically tested strain.
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Sequence Data
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-
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