EBV Mutation Detail Information

Virus Mutation EBV Mutation G54498A


Basic Characteristics of Mutations
Mutation Site G54498A
Mutation Site Sentence Three were synonymous mutations (G54498A, T54615C and C54711T), and two were nonsynonymous mutations (G54610T, T54637G).
Mutation Level Nucleotide level
Mutation Type Synonymous substitution
Gene/Protein/Region BHRF1
Standardized Encoding Gene BHRF1  
Genotype/Subtype -
Viral Reference V01555
Functional Impact and Mechanisms
Disease Leukemia, Myeloid, Acute     Leukemia, Lymphoblastic, Acute     Leukemia, Myelogenous, Chronic     Leukemia, Lymphocytic, Chronic     Myelodysplastic/Myeloproliferative Neoplasms     Acute Undifferentiated Leukemia     Hodgkin Disease     B-Cell Lymphoblastic Leukemia-Lymphoma     T-Cell Lymphoblastic Leukemia-Lymphoma     Lymphoma, Large B-Cell, Diffuse     Lymphoma, Mantle-Cell     Lymphoma, Follicular     Lymphoma, T-Cell, Peripheral     Burkitt Lymphoma     Lymphoma, Extranodal NK-T-Cell     Leukemia-Lymphoma, Adult T-Cell     Leukemia, Large Granular Lymphocytic     Immunoblastic Lymphadenopathy    
Immune -
Target Gene -
Clinical and Epidemiological Correlations
Clinical Information Y
Treatment -
Location China
Literature Information
PMID 37243920
Title Genetic variability and mutation of Epstein-Barr virus (EBV)-encoded LMP-1 and BHRF-1 genes in EBV-infected patients: identification of precise targets for development of personalized EBV vaccines
Author Wang Y,Rong Y,Yang L,Lu Z
Journal Virus genes
Journal Info 2023 Aug;59(4):541-553
Abstract The critical Epstein-Barr virus (EBV)-encoded latent membrane protein 1 (LMP-1) and BamHI fragment H rightward open reading frame 1 (BHRF-1) genes affect EBV-mediated malignant transformation and virus replication during EBV infection. Therefore, these two genes are considered ideal targets for EBV vaccine development. However, gene mutations in LMP-1 and BHRF-1 in different cohorts may affect the biological functions of EBV, which would seriously hinder development of personalized vaccines for EBV. In the present study, by performing nested polymerase chain reaction (nested PCR) and DNA sequence techniques, we analyzed the nucleotide variability and phylogeny of LMP-1 containing a 30 bp deletion region (del-LMP-1) and BHRF-1 in EBV-infected patients (N = 382) and healthy persons receiving physical examination (N = 98; defined as the control group) in Yunnan Province, China. Three BHRF-1 subtypes were identified in this study: 79V88V, 79L88L, and 79V88L, with mutation frequencies of 58.59%, 24.24%, and 17.17%, respectively. Compared with the control group, the distribution of BHRF-1 subtypes of the three groups showed no significant difference, suggesting that BHRF-1 is highly conserved in EBV-related samples. In addition, a short fragment of del-LMP-1 was found in 133 cases, and the nucleotide variation rate was 87.50% (133/152). For del-LMP-1, a significant distribution in three groups was detected, as characterized by a high mutation rate. In conclusion, our study illustrates gene variability and mutations of EBV-encoded del-LMP-1 and BHRF-1 in clinical samples. Highly mutated LMP-1 might be associated with various types of EBV-related diseases, indicating that BHRF-1 combined with LMP-1 may be used as an ideal target for development of EBV personalized vaccines.
Sequence Data KY454054-KY454158
Mutation Information
Note
Basic Characteristics of Mutations
  • Mutation Site: The specific location in a gene or protein sequence where a change occurs.
  • Mutation Level: The level at which a mutation occurs, including the nucleotide or amino acid level.
  • Mutation Type: The nature of the mutation, such as missense mutation, nonsense mutation, synonymous mutation, etc.
  • Gene/Protein/Region: Refers to the specific region of the virus where the mutation occurs. Including viral genes, viral proteins, or a specific viral genome region. If the article does not specifically indicate the relationship between the mutation and its correspondence, the main
  • Gene/Protein/Region studied in the article is marked.
  • Genotype/Subtype: Refers to the viral genotype or subtype where the mutation occurs. If the article does not specifically indicate the relationship between the mutation and its correspondence, the main Genotype/Subtype studied in the article is marked.
  • Viral Reference: Refers to the standard virus strain used to compare and analyze viral sequences.
Functional Impact and Mechanisms
  • Disease: An abnormal physiological state with specific symptoms and signs caused by viral infection.
  • Immune: The article focuses on the study of mutations and immune.
  • Target Gene: Host genes that viral mutations may affect.
Clinical and Epidemiological Correlations
  • Clinical Information: The study is a clinical or epidemiological study and provides basic information about the population.
  • Treatment: The study mentioned a certain treatment method, such as drug resistance caused by mutations. If the study does not specifically indicate the relationship between mutations and their correspondence treatment, the main treatment studied in the article is marked.
  • Location: The source of the research data.
Literature Information
  • Sequence Data: The study provides the data accession number.