SARS-CoV-2 Mutation Detail Information

Virus Mutation SARS-CoV-2 Mutation G75V


Basic Characteristics of Mutations
Mutation Site G75V
Mutation Site Sentence The Lambda variant (C.37 lineage) contains six substitution mutations (G75V, T76I, L452Q, F490S, D614G, and T859N) and a 7-amino-acid deletion in the N-terminal domain (NTD) (RSYLTPGD246-253N) of the spike (S) protein, as well as six substitution mutations (T1246I, P2287S, F2387V, L3201P, T3255I, G3278S) and a 2-amino-acid deletion (del3675/3677) in ORF1.
Mutation Level Amino acid level
Mutation Type Nonsynonymous substitution
Gene/Protein/Region S
Standardized Encoding Gene S  
Genotype/Subtype C.37
Viral Reference NC_045512
Functional Impact and Mechanisms
Disease COVID-19    
Immune -
Target Gene -
Clinical and Epidemiological Correlations
Clinical Information -
Treatment -
Location -
Literature Information
PMID 36786950
Title Evidence of natural selection and dominance of SARS-CoV-2 variant Lambda (C.37) over variants of concern in Cusco, Peru
Author Quispe-Ricalde MA,Castelan-Sanchez HG,Meza-Rodriguez PM,Davila-Ramos S,Sierra JL,Batista-Garcia R,Concha-Velasco F,Lucana SF,De Santa Cruz J,Zea V,Galarza M,Caceres-Rey O,Tsukayama P,Foronda P,Soto-Chambi BJ,Abreu N
Journal Archives of virology
Journal Info 2023 Feb 14;168(3):88
Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) lineage C.37 (Lambda) has spread rapidly in Peru and other Latin American countries. However, most studies in Peru have focused on Lima, the capital city, without knowing the dynamics of the spread of the variant in other departments. Cusco, Peru, is one of the most popular departments in the country for tourists, so the introduction of new variants of SARS-CoV-2 might occur despite closure of the borders. Therefore, in this work, we analyzed the variants circulating in Cusco. The aim of this work was to better understand the distribution of SARS-CoV-2 lineages circulating in Cusco and to characterize the genomes of these strains. To this end, 46 SARS-CoV-2 genomes from vaccinated and unvaccinated patients were sequenced in the first half of 2021. The genomes were analyzed using phylogenetic and natural selection methods. Phylogenetic trees from Cusco showed dominance of the Lambda lineage over the variants of concern (VOCs), and there was no clustering of variants by district. Natural selection analysis revealed mutations, mainly in the spike protein, at positions 75, 246, 247, 707, 769, and 1020. In addition, we found that unvaccinated patients accumulated more new mutations than did vaccinated patients, and these included the F101Y mutation in ORF7a, E419A in NSP3, a deletion in S (21,618-22,501), and a deletion in ORF3a (25,437-26,122).
Sequence Data EPI_ISL_3020244; EPI_ISL_3020245; EPI_ISL_3020248; EPI_ISL_3020249; EPI_ISL_3020250; EPI_ISL_3707384; EPI_ISL_3020255; EPI_ISL_3020257; EPI_ISL_3020260; EPI_ISL_3020261; EPI_ISL_3020262; EPI_ISL_3020263; EPI_ISL_3020268; EPI_ISL_3020269; EPI_ISL_3020270; EPI_ISL_3020271; EPI_ISL_3020272; EPI_ISL_13522153; EPI_ISL_13522163; EPI_ISL_13522152; EPI_ISL_13522154; EPI_ISL_13522155; EPI_ISL_13522156; EPI_ISL_13522157; EPI_ISL_13522158; EPI_ISL_13522159; EPI_ISL_13522160; EPI_ISL_13522162; EPI_ISL_3020246; EPI_ISL_3020251; EPI_ISL_3020252; EPI_ISL_3020253; EPI_ISL_3020258; EPI_ISL_3020259; EPI_ISL_3707383; EPI_ISL_3020264; EPI_ISL_3020265; EPI_ISL_3020266; EPI_ISL_3020267; EPI_ISL_3020273
Mutation Information
Note
Basic Characteristics of Mutations
  • Mutation Site: The specific location in a gene or protein sequence where a change occurs.
  • Mutation Level: The level at which a mutation occurs, including the nucleotide or amino acid level.
  • Mutation Type: The nature of the mutation, such as missense mutation, nonsense mutation, synonymous mutation, etc.
  • Gene/Protein/Region: Refers to the specific region of the virus where the mutation occurs. Including viral genes, viral proteins, or a specific viral genome region. If the article does not specifically indicate the relationship between the mutation and its correspondence, the main
  • Gene/Protein/Region studied in the article is marked.
  • Genotype/Subtype: Refers to the viral genotype or subtype where the mutation occurs. If the article does not specifically indicate the relationship between the mutation and its correspondence, the main Genotype/Subtype studied in the article is marked.
  • Viral Reference: Refers to the standard virus strain used to compare and analyze viral sequences.
Functional Impact and Mechanisms
  • Disease: An abnormal physiological state with specific symptoms and signs caused by viral infection.
  • Immune: The article focuses on the study of mutations and immune.
  • Target Gene: Host genes that viral mutations may affect.
Clinical and Epidemiological Correlations
  • Clinical Information: The study is a clinical or epidemiological study and provides basic information about the population.
  • Treatment: The study mentioned a certain treatment method, such as drug resistance caused by mutations. If the study does not specifically indicate the relationship between mutations and their correspondence treatment, the main treatment studied in the article is marked.
  • Location: The source of the research data.
Literature Information
  • Sequence Data: The study provides the data accession number.