HTLV1 Mutation Detail Information

Virus Mutation HTLV1 Mutation G8632A


Basic Characteristics of Mutations
Mutation Site G8632A
Mutation Site Sentence Table 5
Mutation Level Nucleotide level
Mutation Type
Gene/Protein/Region LTR
Standardized Encoding Gene
Genotype/Subtype -
Viral Reference -
Functional Impact and Mechanisms
Disease HTLV-1 Infection     Carrier State    
Immune -
Target Gene -
Clinical and Epidemiological Correlations
Clinical Information Y
Treatment -
Location Argentina
Literature Information
PMID 26516904
Title Low Proviral Load is Associated with Indeterminate Western Blot Patterns in Human T-Cell Lymphotropic Virus Type 1 Infected Individuals: Could Punctual Mutations be Related?
Author Canepa C,Salido J,Ruggieri M,Fraile S,Pataccini G,Berini C,Biglione M
Journal Viruses
Journal Info 2015 Oct 28;7(11):5643-58
Abstract BACKGROUND: indeterminate Western blot (WB) patterns are a major concern for diagnosis of human T-cell lymphotropic virus type 1 (HTLV-1) infection, even in non-endemic areas. OBJECTIVES: (a) to define the prevalence of indeterminate WB among different populations from Argentina; (b) to evaluate if low proviral load (PVL) is associated with indeterminate WB profiles; and (c) to describe mutations in LTR and tax sequence of these cases. RESULTS: Among 2031 samples, 294 were reactive by screening. Of them, 48 (16.3%) were WB indeterminate and of those 15 (31.3%) were PCR+. Quantitative real-time PCR (qPCR) was performed to 52 HTLV-1+ samples, classified as Group 1 (G1): 25 WB+ samples from individuals with pathologies; Group 2 (G2): 18 WB+ samples from asymptomatic carriers (AC); and Group 3 (G3): 9 seroindeterminate samples from AC. Median PVL was 4.78, 2.38, and 0.15 HTLV-1 copies/100 PBMCs, respectively; a significant difference (p=0.003) was observed. Age and sex were associated with PVL in G1 and G2, respectively. Mutations in the distal and central regions of Tax Responsive Elements (TRE) 1 and 2 of G3 were observed, though not associated with PVL.The 8403A>G mutation of the distal region, previously related to high PVL, was absent in G3 but present in 50% of WB+ samples (p = 0.03). CONCLUSIONS: indeterminate WB results confirmed later as HTLV-1 positive may be associated with low PVL levels. Mutations in LTR and tax are described; their functional relevance remains to be determined.
Sequence Data KT633516;KT633517;KT633518;KT633519;KT633520;KT633521;KT633522;KT633523;KT633524;KT633525;KT633526;KT633527;KT633528;KT633529; KT633530;KT633531;KT633532;KT633533;KT633534;T633535;KT633536;L02534;Y17014;Z32527;L76307;AY818432;Y17017;L76310;DI3784;AY324785;U12804;U12806;U12807;Y16481;AF054627;U32557;M37299;Y16484;Y16487;Y16485;U19949;J02029;Z31661;AY324788;Y16483;EU622623;EU622620;L03562;M81248;AY324777;EU622605;EU622609;EU622588;AY374468;AY374466;EU622586;EU622590;L76026;L76025;L76034;EU622600;EU622584;EU622589;AY374459;AY374462;AY374467;AY374460;L36905;EU622593;DQ323759;L42253;L42255;U87261;D23690;U87264;U32552;DQ323755;DQ323750;DQ323754;DQ323753;EU622615;EU622625;EU622616;EU622611;EU622608;EU622614;EU622585;AF063819;DQ323751;AF007755;X88871;X88872;L76028;DQ323755;EU622603;Y16480;AY324782;EU622604;AY374465;AY374461;EU622612;EU622601;X88875;DQ323757;Y16478;X88877;X88873;DQ323760;X88876;AY324783;Y16476;Y16479;Y16477;FJ751855;EU622596;EU622598;EU622606;EU622607;EU622595;EU622594;EU622592;EU622621;EU622591;FJ758161;FJ751856;EU622587;FJ751858;FJ751854;EU622622;AY324793;AY324778;EU622624;EU622602;Y16475;EU622618;AF007751;EU622619;EU622597;FJ751857;EU622610;EU622613
Mutation Information
Note
Basic Characteristics of Mutations
  • Mutation Site: The specific location in a gene or protein sequence where a change occurs.
  • Mutation Level: The level at which a mutation occurs, including the nucleotide or amino acid level.
  • Mutation Type: The nature of the mutation, such as missense mutation, nonsense mutation, synonymous mutation, etc.
  • Gene/Protein/Region: Refers to the specific region of the virus where the mutation occurs. Including viral genes, viral proteins, or a specific viral genome region. If the article does not specifically indicate the relationship between the mutation and its correspondence, the main
  • Gene/Protein/Region studied in the article is marked.
  • Genotype/Subtype: Refers to the viral genotype or subtype where the mutation occurs. If the article does not specifically indicate the relationship between the mutation and its correspondence, the main Genotype/Subtype studied in the article is marked.
  • Viral Reference: Refers to the standard virus strain used to compare and analyze viral sequences.
Functional Impact and Mechanisms
  • Disease: An abnormal physiological state with specific symptoms and signs caused by viral infection.
  • Immune: The article focuses on the study of mutations and immune.
  • Target Gene: Host genes that viral mutations may affect.
Clinical and Epidemiological Correlations
  • Clinical Information: The study is a clinical or epidemiological study and provides basic information about the population.
  • Treatment: The study mentioned a certain treatment method, such as drug resistance caused by mutations. If the study does not specifically indicate the relationship between mutations and their correspondence treatment, the main treatment studied in the article is marked.
  • Location: The source of the research data.
Literature Information
  • Sequence Data: The study provides the data accession number.