SARS-CoV-2 Mutation Detail Information

Virus Mutation SARS-CoV-2 Mutation G8X


Basic Characteristics of Mutations
Mutation Site G8X
Mutation Site Sentence Although most XBB.1 harbor the ORF8:G8stop mutation, this mutation occurred during the diversification of XBB.1 rather than in the most recent common ancestor (MRCA) of XBB.1.
Mutation Level Amino acid level
Mutation Type Nonsense mutation
Gene/Protein/Region ORF8
Standardized Encoding Gene ORF8  
Genotype/Subtype XBB.1
Viral Reference NC_045512.2
Functional Impact and Mechanisms
Disease COVID-19     Cell line    
Immune -
Target Gene -
Clinical and Epidemiological Correlations
Clinical Information -
Treatment -
Location -
Literature Information
PMID 38332154
Title Virological characteristics of the SARS-CoV-2 Omicron XBB.1.5 variant
Author Tamura T,Irie T,Deguchi S,Yajima H,Tsuda M,Nasser H,Mizuma K,Plianchaisuk A,Suzuki S,Uriu K,Begum MM,Shimizu R,Jonathan M,Suzuki R,Kondo T,Ito H,Kamiyama A,Yoshimatsu K,Shofa M,Hashimoto R,Anraku Y,Kimura KT,Kita S,Sasaki J,Sasaki-Tabata K,Maenaka K,Nao N,Wang L,Oda Y,Ikeda T,Saito A,Matsuno K,Ito J,Tanaka S,Sato K,Hashiguchi T,Takayama K,Fukuhara T
Journal Nature communications
Journal Info 2024 Feb 8;15(1):1176
Abstract Circulation of SARS-CoV-2 Omicron XBB has resulted in the emergence of XBB.1.5, a new Variant of Interest. Our phylogenetic analysis suggests that XBB.1.5 evolved from XBB.1 by acquiring the S486P spike (S) mutation, subsequent to the acquisition of a nonsense mutation in ORF8. Neutralization assays showed similar abilities of immune escape between XBB.1.5 and XBB.1. We determine the structural basis for the interaction between human ACE2 and the S protein of XBB.1.5, showing similar overall structures between the S proteins of XBB.1 and XBB.1.5. We provide the intrinsic pathogenicity of XBB.1 and XBB.1.5 in hamsters. Importantly, we find that the ORF8 nonsense mutation of XBB.1.5 resulted in impairment of MHC suppression. In vivo experiments using recombinant viruses reveal that the XBB.1.5 mutations are involved with reduced virulence of XBB.1.5. Together, our study identifies the two viral functions defined the difference between XBB.1 and XBB.1.5.
Sequence Data -
Mutation Information
Note
Basic Characteristics of Mutations
  • Mutation Site: The specific location in a gene or protein sequence where a change occurs.
  • Mutation Level: The level at which a mutation occurs, including the nucleotide or amino acid level.
  • Mutation Type: The nature of the mutation, such as missense mutation, nonsense mutation, synonymous mutation, etc.
  • Gene/Protein/Region: Refers to the specific region of the virus where the mutation occurs. Including viral genes, viral proteins, or a specific viral genome region. If the article does not specifically indicate the relationship between the mutation and its correspondence, the main
  • Gene/Protein/Region studied in the article is marked.
  • Genotype/Subtype: Refers to the viral genotype or subtype where the mutation occurs. If the article does not specifically indicate the relationship between the mutation and its correspondence, the main Genotype/Subtype studied in the article is marked.
  • Viral Reference: Refers to the standard virus strain used to compare and analyze viral sequences.
Functional Impact and Mechanisms
  • Disease: An abnormal physiological state with specific symptoms and signs caused by viral infection.
  • Immune: The article focuses on the study of mutations and immune.
  • Target Gene: Host genes that viral mutations may affect.
Clinical and Epidemiological Correlations
  • Clinical Information: The study is a clinical or epidemiological study and provides basic information about the population.
  • Treatment: The study mentioned a certain treatment method, such as drug resistance caused by mutations. If the study does not specifically indicate the relationship between mutations and their correspondence treatment, the main treatment studied in the article is marked.
  • Location: The source of the research data.
Literature Information
  • Sequence Data: The study provides the data accession number.