HBV Mutation Detail Information

Virus Mutation HBV Mutation H580Q


Basic Characteristics of Mutations
Mutation Site H580Q
Mutation Site Sentence These nucleotide mutations included 12 amino acid mutations in the pre-S1 gene (pre-S1_S78I), S gene (S21W, D144A, K160N, S174N, and I226S), P gene (E258D, G294R, I515L, H580Q, and P583S), and X gene (H52Y).
Mutation Level Amino acid level
Mutation Type Nonsynonymous substitution
Gene/Protein/Region RT
Standardized Encoding Gene P  
Genotype/Subtype B1
Viral Reference HBVB1:AB287326;AB900104;AB287327;D23678;AB302095;AB931168;AB931169;AB073845;AB073858;AB900112;LC461174;LC461175;AB073852;AB073849;A864210;AB106884;AB882708;AB362933;AB900103;AB900097;D50522;AB073847;AB900105;AB900106;AB900095;AB073844;LC603638;LC603637;AB073843;AB900108;AB073842;AB073846;AB073854;AB073855;AB073857;AB073856;AB073851;AB900102;AB246341;D23679;LC500247;AB010292;AB010291;AB073850;AB602818;AB246342;AB246343;AB073838;AB010289;HBVB2:AB900107;AB073830;AB073837;AB073821;B2-AB073827;B2-AB031266;HBVB3:B3-M54923;B3-AB033555;B3-AB033543;B3-AB033551
Functional Impact and Mechanisms
Disease Hepatitis B Virus Infection    
Immune -
Target Gene -
Clinical and Epidemiological Correlations
Clinical Information Y
Treatment -
Location Japan
Literature Information
PMID 38748198
Title Spontaneous reactivation of hepatitis B virus with multiple novel mutations in an elderly patient with resolved hepatitis B virus infection
Author Sasaki T,Kakisaka K,Miyasaka A,Nishiya M,Yanagawa N,Kuroda H,Matsumoto T,Takahashi M,Okamoto H
Journal Clinical journal of gastroenterology
Journal Info 2024 Aug;17(4):683-690
Abstract Spontaneous reactivation of the Hepatitis B virus (HBV) is rare in individuals with previously resolved infections. This report presents the case of a 71 year-old Japanese woman who experienced HBV reactivation without any prior immunosuppressive therapy or chemotherapy. Before the onset of liver injury, the patient was negative for hepatitis B surface antigen (HBsAg) but positive for hepatitis B surface antibody. She subsequently developed liver injury, with the reappearance of HBsAg and HBV DNA. The patient was successfully treated with tenofovir alafenamide, and prednisolone. Full-genome sequencing of HBV revealed subgenotype B1 without hepatitis B e-negative mutations in the precore and core promoter regions and 12 amino acid alterations in the pre-S1/S, P, and X genes. Notably, the S gene mutations D144A and K160N, which alter the antigenicity of HBsAg and potentially contribute to its reactivation, were identified. This case emphasizes the importance of vigilance for spontaneous reactivation of resolved HBV, highlighting the need for comprehensive genomic analysis to understand the associated virological intricacies.
Sequence Data HB22-1126;LC791220
Mutation Information
Note
Basic Characteristics of Mutations
  • Mutation Site: The specific location in a gene or protein sequence where a change occurs.
  • Mutation Level: The level at which a mutation occurs, including the nucleotide or amino acid level.
  • Mutation Type: The nature of the mutation, such as missense mutation, nonsense mutation, synonymous mutation, etc.
  • Gene/Protein/Region: Refers to the specific region of the virus where the mutation occurs. Including viral genes, viral proteins, or a specific viral genome region. If the article does not specifically indicate the relationship between the mutation and its correspondence, the main
  • Gene/Protein/Region studied in the article is marked.
  • Genotype/Subtype: Refers to the viral genotype or subtype where the mutation occurs. If the article does not specifically indicate the relationship between the mutation and its correspondence, the main Genotype/Subtype studied in the article is marked.
  • Viral Reference: Refers to the standard virus strain used to compare and analyze viral sequences.
Functional Impact and Mechanisms
  • Disease: An abnormal physiological state with specific symptoms and signs caused by viral infection.
  • Immune: The article focuses on the study of mutations and immune.
  • Target Gene: Host genes that viral mutations may affect.
Clinical and Epidemiological Correlations
  • Clinical Information: The study is a clinical or epidemiological study and provides basic information about the population.
  • Treatment: The study mentioned a certain treatment method, such as drug resistance caused by mutations. If the study does not specifically indicate the relationship between mutations and their correspondence treatment, the main treatment studied in the article is marked.
  • Location: The source of the research data.
Literature Information
  • Sequence Data: The study provides the data accession number.