SARS-CoV-2 Mutation Detail Information

Virus Mutation SARS-CoV-2 Mutation I2230T


Basic Characteristics of Mutations
Mutation Site I2230T
Mutation Site Sentence Our results further showed that at least two site mutations in B.1.1.7 resulted in a decrease in CD8+ T cell activation and a possible immune evasion, namely A1708D mutation in ORF1ab1707-1716 and I2230T mutation in ORF1ab2230-2238.
Mutation Level Amino acid level
Mutation Type Nonsynonymous substitution
Gene/Protein/Region ORF1ab
Standardized Encoding Gene ORF1ab  
Genotype/Subtype B.1.1.7
Viral Reference -
Functional Impact and Mechanisms
Disease COVID-19    
Immune -
Target Gene -
Clinical and Epidemiological Correlations
Clinical Information -
Treatment -
Location -
Literature Information
PMID 35194575
Title SARS-CoV-2 variant B.1.1.7 caused HLA-A2(+) CD8(+) T cell epitope mutations for impaired cellular immune response
Author Xiao C,Mao L,Wang Z,Gao L,Zhu G,Su J,Chen X,Yuan J,Hu Y,Yin Z,Xie J,Ji W,Niu H,Gao F,Luo OJ,Xiao L,Wang P,Chen G
Journal iScience
Journal Info 2022 Mar 18;25(3):103934
Abstract Here, we evaluated the immune properties of the HLA-A2 restricted CD8(+) T cell epitopes containing mutations from B.1.1.7, and furthermore performed a comprehensive analysis of the SARS-CoV-2 specific CD8(+) T cell responses from COVID-19 convalescent patients and SARS-CoV-2 vaccinees recognizing the ancestral Wuhan strain compared to B.1.1.7. First, most of the predicted CD8(+) T cell epitopes showed proper binding with HLA-A2, whereas epitopes from B.1.1.7 had lower binding capability than those from the ancestral strain. In addition, these peptides could effectively induce the activation and cytotoxicity of CD8(+) T cells. Our results further showed that at least two site mutations in B.1.1.7 resulted in a decrease in CD8(+) T cell activation and a possible immune evasion, namely A1708D mutation in ORF1ab(1707-1716) and I2230T mutation in ORF1ab(2230-2238). Our current analysis provides information that contributes to the understanding of SARS-CoV-2-specific CD8(+) T cell responses elicited by infection of mutated strains or vaccination.
Sequence Data -
Mutation Information
Note
Basic Characteristics of Mutations
  • Mutation Site: The specific location in a gene or protein sequence where a change occurs.
  • Mutation Level: The level at which a mutation occurs, including the nucleotide or amino acid level.
  • Mutation Type: The nature of the mutation, such as missense mutation, nonsense mutation, synonymous mutation, etc.
  • Gene/Protein/Region: Refers to the specific region of the virus where the mutation occurs. Including viral genes, viral proteins, or a specific viral genome region. If the article does not specifically indicate the relationship between the mutation and its correspondence, the main
  • Gene/Protein/Region studied in the article is marked.
  • Genotype/Subtype: Refers to the viral genotype or subtype where the mutation occurs. If the article does not specifically indicate the relationship between the mutation and its correspondence, the main Genotype/Subtype studied in the article is marked.
  • Viral Reference: Refers to the standard virus strain used to compare and analyze viral sequences.
Functional Impact and Mechanisms
  • Disease: An abnormal physiological state with specific symptoms and signs caused by viral infection.
  • Immune: The article focuses on the study of mutations and immune.
  • Target Gene: Host genes that viral mutations may affect.
Clinical and Epidemiological Correlations
  • Clinical Information: The study is a clinical or epidemiological study and provides basic information about the population.
  • Treatment: The study mentioned a certain treatment method, such as drug resistance caused by mutations. If the study does not specifically indicate the relationship between mutations and their correspondence treatment, the main treatment studied in the article is marked.
  • Location: The source of the research data.
Literature Information
  • Sequence Data: The study provides the data accession number.