HPV Mutation Detail Information

Virus Mutation HPV Mutation L257V


Basic Characteristics of Mutations
Mutation Site L257V
Mutation Site Sentence The sequence analysis showed 27 substitutions at 25 nucleotides located between positions 2815 and 3766 (A2815G, T2817G, C2833T, T2835G, C2839A, T2841A, C2876G, C2876T T2877A, T2881G, T2881A, A2885T, A2910C, A2918T, G3187T, C3401A, C3409T, C3461T, C3464T, A3509T, T3523G, G3533T, A3534C, C3535T, C3573A, A3691G, G3766A) leading to an amino acid change (N21E, R27W, H29K, A41G, A41V, Y43D, Y43N, Y44F, K52N, N55I, V145L, A216E, P219S, T236M, T237I, H252L, L257V, D260S, S261L, S273R, T313A, D338N), while other nucleotide substitutions (C2892G, C2922T, A2937G, A3024G, A3186T, C3408T, C3438A, A3454T, C3504T, T3560G) were silent or encoded the STOP codon (C2948G, A2950T).
Mutation Level Amino acid level
Mutation Type Nonsynonymous substitution
Gene/Protein/Region E2
Standardized Encoding Gene E2
Genotype/Subtype HPV16
Viral Reference K02718
Functional Impact and Mechanisms
Disease Squamous Intraepithelial Lesions    
Immune -
Target Gene -
Clinical and Epidemiological Correlations
Clinical Information Y
Treatment -
Location Poland
Literature Information
PMID 33909391
Title Sequence variation analysis of the E1 and E2 genes of human papillomavirus type 16 in cervical lesions in women from the south of Poland
Author Sitarz K,Kopec J,Zawilinska B,Klimek M,Szostek S
Journal Acta biochimica Polonica
Journal Info 2021 Apr 28;68(2):341-346
Abstract The E1 and E2 genes of the human papillomavirus encode the so-called early proteins, their sequences are conserved, and regulatory functions are associated with the viral oncoproteins. The purpose of this study is to determine the HPV16 E1 and E2 mutations appearing in the female population of southern Poland, depending on the severity of cervical pathological changes. We also take into account the number of E1 and E2 mutations detected in the E6 gene variant (350G or 350T). This publication is one of the first in the Central and Eastern Europe to deal with this topic. We identified 4 mutations in the E1 gene and 24 mutations in the E2 gene that have not been described so far. In three cases of squamous cell carcinoma a C3409T mutation occurred, which is widely described as oncogenic. This mutation lies in the 3243-3539 area of the E2 hinge region. Statistical analyses show a possible relationship of mutations in this area with oncogenesis. The discovered dependencies may be important in the context of oncogenesis, however, a study with a larger group of patients is needed in order to confirm this view.
Sequence Data -
Mutation Information
Note
Basic Characteristics of Mutations
  • Mutation Site: The specific location in a gene or protein sequence where a change occurs.
  • Mutation Level: The level at which a mutation occurs, including the nucleotide or amino acid level.
  • Mutation Type: The nature of the mutation, such as missense mutation, nonsense mutation, synonymous mutation, etc.
  • Gene/Protein/Region: Refers to the specific region of the virus where the mutation occurs. Including viral genes, viral proteins, or a specific viral genome region. If the article does not specifically indicate the relationship between the mutation and its correspondence, the main
  • Gene/Protein/Region studied in the article is marked.
  • Genotype/Subtype: Refers to the viral genotype or subtype where the mutation occurs. If the article does not specifically indicate the relationship between the mutation and its correspondence, the main Genotype/Subtype studied in the article is marked.
  • Viral Reference: Refers to the standard virus strain used to compare and analyze viral sequences.
Functional Impact and Mechanisms
  • Disease: An abnormal physiological state with specific symptoms and signs caused by viral infection.
  • Immune: The article focuses on the study of mutations and immune.
  • Target Gene: Host genes that viral mutations may affect.
Clinical and Epidemiological Correlations
  • Clinical Information: The study is a clinical or epidemiological study and provides basic information about the population.
  • Treatment: The study mentioned a certain treatment method, such as drug resistance caused by mutations. If the study does not specifically indicate the relationship between mutations and their correspondence treatment, the main treatment studied in the article is marked.
  • Location: The source of the research data.
Literature Information
  • Sequence Data: The study provides the data accession number.