HPV Mutation Detail Information

Virus Mutation HPV Mutation L52A


Basic Characteristics of Mutations
Mutation Site L52A
Mutation Site Sentence Expression of an E6 mutant unable to interact with E6AP (L52A) [42] impaired p53 degradation, but retained the ability to enhance STAT3 phosphorylation.
Mutation Level Amino acid level
Mutation Type Nonsynonymous substitution
Gene/Protein/Region E6
Standardized Encoding Gene E6
Genotype/Subtype HPV18
Viral Reference -
Functional Impact and Mechanisms
Disease -
Immune -
Target Gene TP53    STAT3   
Clinical and Epidemiological Correlations
Clinical Information -
Treatment -
Location -
Literature Information
PMID 29630659
Title STAT3 activation by E6 is essential for the differentiation-dependent HPV18 life cycle
Author Morgan EL,Wasson CW,Hanson L,Kealy D,Pentland I,McGuire V,Scarpini C,Coleman N,Arthur JSC,Parish JL,Roberts S,Macdonald A
Journal PLoS pathogens
Journal Info 2018 Apr 9;14(4):e1006975
Abstract Introduction
Sequence Data -
Mutation Information
Note
Basic Characteristics of Mutations
  • Mutation Site: The specific location in a gene or protein sequence where a change occurs.
  • Mutation Level: The level at which a mutation occurs, including the nucleotide or amino acid level.
  • Mutation Type: The nature of the mutation, such as missense mutation, nonsense mutation, synonymous mutation, etc.
  • Gene/Protein/Region: Refers to the specific region of the virus where the mutation occurs. Including viral genes, viral proteins, or a specific viral genome region. If the article does not specifically indicate the relationship between the mutation and its correspondence, the main
  • Gene/Protein/Region studied in the article is marked.
  • Genotype/Subtype: Refers to the viral genotype or subtype where the mutation occurs. If the article does not specifically indicate the relationship between the mutation and its correspondence, the main Genotype/Subtype studied in the article is marked.
  • Viral Reference: Refers to the standard virus strain used to compare and analyze viral sequences.
Functional Impact and Mechanisms
  • Disease: An abnormal physiological state with specific symptoms and signs caused by viral infection.
  • Immune: The article focuses on the study of mutations and immune.
  • Target Gene: Host genes that viral mutations may affect.
Clinical and Epidemiological Correlations
  • Clinical Information: The study is a clinical or epidemiological study and provides basic information about the population.
  • Treatment: The study mentioned a certain treatment method, such as drug resistance caused by mutations. If the study does not specifically indicate the relationship between mutations and their correspondence treatment, the main treatment studied in the article is marked.
  • Location: The source of the research data.
Literature Information
  • Sequence Data: The study provides the data accession number.