IV Mutation Detail Information

Virus Mutation IV Mutation M105K


Basic Characteristics of Mutations
Mutation Site M105K
Mutation Site Sentence We show that three mutations in particular occur with high frequency in the viral nucleoprotein (NP) protein (G102R, M105K and D375N) in a specific structural area upon in vivo adaptation.
Mutation Level Amino acid level
Mutation Type Nonsynonymous substitution
Gene/Protein/Region NP
Standardized Encoding Gene NP
Genotype/Subtype H1N1
Viral Reference HQ104928.1;HQ104926.1;HQ104924.1;HM598305.1;HQ104929.1;HQ104927.1;HQ104925.1;GU480807.1
Functional Impact and Mechanisms
Disease Influenza A    
Immune Y
Target Gene KPNA4    KPNA2   
Clinical and Epidemiological Correlations
Clinical Information -
Treatment -
Location -
Literature Information
PMID 31044563
Title Alternative interaction sites in the influenza A virus nucleoprotein mediate viral escape from the importin-alpha7 mediated nuclear import pathway
Author Resa-Infante P,Bonet J,Thiele S,Alawi M,Stanelle-Bertram S,Tuku B,Beck S,Oliva B,Gabriel G
Journal The FEBS journal
Journal Info 2019 Sep;286(17):3374-3388
Abstract Influenza A viruses are able to adapt to restrictive conditions due to their high mutation rates. Importin-alpha7 is a component of the nuclear import machinery required for avian-mammalian adaptation and replicative fitness in human cells. Here, we elucidate the mechanisms by which influenza A viruses may escape replicative restriction in the absence of importin-alpha7. To address this question, we assessed viral evolution in mice lacking the importin-alpha7 gene. We show that three mutations in particular occur with high frequency in the viral nucleoprotein (NP) protein (G102R, M105K and D375N) in a specific structural area upon in vivo adaptation. Moreover, our findings suggest that the adaptive NP mutations mediate viral escape from importin-alpha7 requirement likely due to the utilization of alternative interaction sites in NP beyond the classical nuclear localization signal. However, viral escape from importin-alpha7 by mutations in NP is, at least in part, associated with reduced viral replication highlighting the crucial contribution of importin-alpha7 to replicative fitness in human cells.
Sequence Data PRJEB32637
Mutation Information
Note
Basic Characteristics of Mutations
  • Mutation Site: The specific location in a gene or protein sequence where a change occurs.
  • Mutation Level: The level at which a mutation occurs, including the nucleotide or amino acid level.
  • Mutation Type: The nature of the mutation, such as missense mutation, nonsense mutation, synonymous mutation, etc.
  • Gene/Protein/Region: Refers to the specific region of the virus where the mutation occurs. Including viral genes, viral proteins, or a specific viral genome region. If the article does not specifically indicate the relationship between the mutation and its correspondence, the main
  • Gene/Protein/Region studied in the article is marked.
  • Genotype/Subtype: Refers to the viral genotype or subtype where the mutation occurs. If the article does not specifically indicate the relationship between the mutation and its correspondence, the main Genotype/Subtype studied in the article is marked.
  • Viral Reference: Refers to the standard virus strain used to compare and analyze viral sequences.
Functional Impact and Mechanisms
  • Disease: An abnormal physiological state with specific symptoms and signs caused by viral infection.
  • Immune: The article focuses on the study of mutations and immune.
  • Target Gene: Host genes that viral mutations may affect.
Clinical and Epidemiological Correlations
  • Clinical Information: The study is a clinical or epidemiological study and provides basic information about the population.
  • Treatment: The study mentioned a certain treatment method, such as drug resistance caused by mutations. If the study does not specifically indicate the relationship between mutations and their correspondence treatment, the main treatment studied in the article is marked.
  • Location: The source of the research data.
Literature Information
  • Sequence Data: The study provides the data accession number.