HBV Mutation Detail Information

Virus Mutation HBV Mutation M204I


Basic Characteristics of Mutations
Mutation Site M204I
Mutation Site Sentence LMV-resistant mutations (rtL180M and/or rtM204VI) were detected in 9 patients before ETV treatment and not in another 5 patients before and after the treatment.
Mutation Level Amino acid level
Mutation Type Nonsynonymous substitution
Gene/Protein/Region RT
Standardized Encoding Gene P  
Genotype/Subtype -
Viral Reference -
Functional Impact and Mechanisms
Disease Hepatitis B, Chronic    
Immune -
Target Gene -
Clinical and Epidemiological Correlations
Clinical Information -
Treatment Lamivudine(LAM)
Location China
Literature Information
PMID 23968804
Title Dynamics of hepatitis B virus resistance substitutions correlates with virological response in lamivudine-refractory patients with entecavir rescue monotherapy
Author Zhang Y,He S,Li QL,Guo JJ
Journal Virus research
Journal Info 2013 Nov 6;177(2):156-62
Abstract Entecavir (ETV) demonstrates potent antiviral effects against lamivudine (LMV)-resistant hepatitis B virus (HBV). This study was designed to investigate the impact of LMV resistance mutations on the outcome of ETV rescue therapy in LMV-refractory patients. Twenty-six chronic hepatitis B patients who received ETV monotherapy for LMV resistance were enrolled. Dynamics of HBV DNA levels were monitored before and during ETV rescue therapy. Mutations in the HBV reverse transcriptase were examined by sequencing. LMV-resistant mutations (rtL180M and/or rtM204VI) were detected in 9 patients before ETV treatment and not in another 5 patients before and after the treatment. ETV therapy resulted in a greater reduction in the HBV DNA load in the patients with out LMV-associated mutations before treatment than in those with. Six patients with 100% LMV-resistant HBV variants at week 12 posttreatment had significantly (P<0.01) greater HBV DNA levels at the end of follow-up than the other patients studied. A comparable outcome was achieved between the patients with or without emergence of LMV-resistant mutations during the ETV treatment. In conclusion, patients without 100% LMV-resistant HBV mutants at week 12 and those without LMV-resistant mutations before treatment show a better response to ETV rescue therapy than the corresponding others. Therefore, individual treatment optimization is of significance in improving the efficacy of antiviral therapy for patients with chronic HBV infection.
Sequence Data -
Mutation Information
Note
Basic Characteristics of Mutations
  • Mutation Site: The specific location in a gene or protein sequence where a change occurs.
  • Mutation Level: The level at which a mutation occurs, including the nucleotide or amino acid level.
  • Mutation Type: The nature of the mutation, such as missense mutation, nonsense mutation, synonymous mutation, etc.
  • Gene/Protein/Region: Refers to the specific region of the virus where the mutation occurs. Including viral genes, viral proteins, or a specific viral genome region. If the article does not specifically indicate the relationship between the mutation and its correspondence, the main
  • Gene/Protein/Region studied in the article is marked.
  • Genotype/Subtype: Refers to the viral genotype or subtype where the mutation occurs. If the article does not specifically indicate the relationship between the mutation and its correspondence, the main Genotype/Subtype studied in the article is marked.
  • Viral Reference: Refers to the standard virus strain used to compare and analyze viral sequences.
Functional Impact and Mechanisms
  • Disease: An abnormal physiological state with specific symptoms and signs caused by viral infection.
  • Immune: The article focuses on the study of mutations and immune.
  • Target Gene: Host genes that viral mutations may affect.
Clinical and Epidemiological Correlations
  • Clinical Information: The study is a clinical or epidemiological study and provides basic information about the population.
  • Treatment: The study mentioned a certain treatment method, such as drug resistance caused by mutations. If the study does not specifically indicate the relationship between mutations and their correspondence treatment, the main treatment studied in the article is marked.
  • Location: The source of the research data.
Literature Information
  • Sequence Data: The study provides the data accession number.