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Basic Characteristics of Mutations
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Mutation Site
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N2152S |
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Mutation Site Sentence
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Mutations were spread over the entire polyprotein with one mutation in the core protein (I30T), four in the glycoproteins E1 and E2 (H202Y / Q434R / F437L / V719L), two in NS2 (I888V / V899A), two in NS3 (V1074I / A1226G), two in NS4B (S1827T / I1834L), five in NS5A (R2080K / N2152S / V2340A / S2341P / Y2385H) and three in NS5B (N2561T / Q2603K / C2864F). |
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Mutation Level
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Amino acid level |
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Mutation Type
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Nonsynonymous substitution |
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Gene/Protein/Region
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NS5A |
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Standardized Encoding Gene
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NS5A
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Genotype/Subtype
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1b |
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Viral Reference
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-
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Functional Impact and Mechanisms
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Disease
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Cell line
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Immune
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- |
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Target Gene
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-
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Clinical and Epidemiological Correlations
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Clinical Information
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- |
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Treatment
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- |
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Location
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- |
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Literature Information
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PMID
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35763545
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Title
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A Hepatitis C virus genotype 1b post-transplant isolate with high replication efficiency in cell culture and its adaptation to infectious virus production in vitro and in vivo
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Author
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Heuss C,Rothhaar P,Burm R,Lee JY,Ralfs P,Haselmann U,Stroh LJ,Colasanti O,Tran CS,Schafer N,Schnitzler P,Merle U,Bartenschlager R,Patel AH,Graw F,Krey T,Laketa V,Meuleman P,Lohmann V
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Journal
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PLoS pathogens
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Journal Info
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2022 Jun 28;18(6):e1010472
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Abstract
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Hepatitis C virus (HCV) is highly diverse and grouped into eight genotypes (gts). Infectious cell culture models are limited to a few subtypes and isolates, hampering the development of prophylactic vaccines. A consensus gt1b genome (termed GLT1) was generated from an HCV infected liver-transplanted patient. GLT1 replicated to an outstanding efficiency in Huh7 cells upon SEC14L2 expression, by use of replication enhancing mutations or with a previously developed inhibitor-based regimen. RNA replication levels almost reached JFH-1, but full-length genomes failed to produce detectable amounts of infectious virus. Long-term passaging led to the adaptation of a genome carrying 21 mutations and concomitant production of high levels of transmissible infectivity (GLT1cc). During the adaptation, GLT1 spread in the culture even in absence of detectable amounts of free virus, likely due to cell-to-cell transmission, which appeared to substantially contribute to spreading of other isolates as well. Mechanistically, genome replication and particle production efficiency were enhanced by adaptation, while cell entry competence of HCV pseudoparticles was not affected. Furthermore, GLT1cc retained the ability to replicate in human liver chimeric mice, which was critically dependent on a mutation in domain 3 of nonstructural protein NS5A. Over the course of infection, only one mutation in the surface glycoprotein E2 consistently reverted to wildtype, facilitating assembly in cell culture but potentially affecting CD81 interaction in vivo. Overall, GLT1cc is an efficient gt1b infectious cell culture model, paving the road to a rationale-based establishment of new infectious HCV isolates and represents an important novel tool for the development of prophylactic HCV vaccines.
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Sequence Data
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-
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