SARS-CoV-2 Mutation Detail Information

Virus Mutation SARS-CoV-2 Mutation N234P


Basic Characteristics of Mutations
Mutation Site N234P
Mutation Site Sentence Brief dispersion of a putative B.1.1.28-derived SARS-CoV-2 lineage harboring additional N234P and E471Q spike protein mutations in individuals crossing the Argentina-Brazil border.
Mutation Level Amino acid level
Mutation Type Nonsynonymous substitution
Gene/Protein/Region S
Standardized Encoding Gene S  
Genotype/Subtype B.1.1.28
Viral Reference EPI_ISL_2918997;EPI_ISL_2919009;EPI_ISL_2918996;EPI_ISL_2919005;EPI_ISL_2919016;EPI_ISL_2919006;EPI_ISL_2918999;EPI_ISL_2919007;EPI_ISL_2918998;EPI_ISL_2919008;EPI_ISL_2919001; EPI_ISL_2919012; EPI_ISL_2919002;EPI_ISL_2919013;EPI_ISL_2919003;EPI_ISL_2919014;EPI_ISL_2919004;EPI_ISL_2919015;EPI_ISL_2919010;EPI_ISL_2919000; EPI_ISL_2919011;EPI_ISL_2925736; EPI_ISL_2928141; EPI_ISL_2928341; EPI_ISL_2928344;EPI_ISL_2928147;EPI_ISL_2928510;EPI_ISL_2928509;EPI_ISL_2928508;EPI_ISL_2928507
Functional Impact and Mechanisms
Disease -
Immune -
Target Gene -
Clinical and Epidemiological Correlations
Clinical Information -
Treatment -
Location Argentina;Brazil
Literature Information
PMID 35753659
Title Brief dispersion of a putative B.1.1.28-derived SARS-CoV-2 lineage harboring additional N234P and E471Q spike protein mutations in individuals crossing the Argentina-Brazil border
Author Soares da Silva M,Gularte JS,Demoliner M,Hansen AW,Heldt FH,Filippi M,Luckmann CB,Malayhka de Abreu Goes Pereira V,de Almeida Vaucher R,Barboza VDS,Giongo JL,Rosa RB,Tarouco da Rocha E,Goulart BK,Fernandes FDS,Pinto JM,Bolzan LP,Medeiros Frescura Duarte MM,Weber MN,Rodrigues de Almeida P,Fleck JD,Spilki FR
Journal Travel medicine and infectious disease
Journal Info 2022 Sep-Oct;49:102390
Abstract BACKGROUND: SARS-CoV-2, the virus that causes COVID-19, is constantly mutating, leading to new variants that culminate in a temporal lineages fluctuation. B.1.1.28 lineage has been evolving in Brazil since February 2020 and originated P.1 (VOC), P.2 (VOI) and other P.Xs proposed as new variants. METHODS AND RESULTS: In this study, through the Illumina platform, we performed the whole-genome sequencing of 26 positive samples of SARS-CoV-2. Employing variant calling analysis on FASTQ reads and phylogenetic inference, we report a brief dispersion of a potentially new B.1.1.28-derived variant detected between 2021 May and June in individuals crossing the border between Brazil and Argentina, and local spread to inpatients from hospitals at the Rio Grande do Sul state capital (Porto Alegre). Besides, the Rio Grande do Sul State SARS-CoV-2 genomic epidemiological data was analyzed and showed an important B.1.1.28 peak in RS at the same period (May-June), even in the presence of a major Gamma wave. CONCLUSIONS: The emergence of a putative B.1.1.28-derived lineage was identified in travelers crossing Brazil-Argentina border representing an important peak of B.1.1.28 in RS State with a decreased in Gamma variant frequency in the same period of time.
Sequence Data -
Mutation Information
Note
Basic Characteristics of Mutations
  • Mutation Site: The specific location in a gene or protein sequence where a change occurs.
  • Mutation Level: The level at which a mutation occurs, including the nucleotide or amino acid level.
  • Mutation Type: The nature of the mutation, such as missense mutation, nonsense mutation, synonymous mutation, etc.
  • Gene/Protein/Region: Refers to the specific region of the virus where the mutation occurs. Including viral genes, viral proteins, or a specific viral genome region. If the article does not specifically indicate the relationship between the mutation and its correspondence, the main
  • Gene/Protein/Region studied in the article is marked.
  • Genotype/Subtype: Refers to the viral genotype or subtype where the mutation occurs. If the article does not specifically indicate the relationship between the mutation and its correspondence, the main Genotype/Subtype studied in the article is marked.
  • Viral Reference: Refers to the standard virus strain used to compare and analyze viral sequences.
Functional Impact and Mechanisms
  • Disease: An abnormal physiological state with specific symptoms and signs caused by viral infection.
  • Immune: The article focuses on the study of mutations and immune.
  • Target Gene: Host genes that viral mutations may affect.
Clinical and Epidemiological Correlations
  • Clinical Information: The study is a clinical or epidemiological study and provides basic information about the population.
  • Treatment: The study mentioned a certain treatment method, such as drug resistance caused by mutations. If the study does not specifically indicate the relationship between mutations and their correspondence treatment, the main treatment studied in the article is marked.
  • Location: The source of the research data.
Literature Information
  • Sequence Data: The study provides the data accession number.