SARS-CoV-2 Mutation Detail Information

Virus Mutation SARS-CoV-2 Mutation N439K


Basic Characteristics of Mutations
Mutation Site N439K
Mutation Site Sentence Circulating SARS-CoV-2 spike N439K variants maintain fitness while evading antibody-mediated immunity.
Mutation Level Amino acid level
Mutation Type Nonsynonymous substitution
Gene/Protein/Region S
Standardized Encoding Gene S  
Genotype/Subtype B.1.141;B.1.258
Viral Reference MN908947
Functional Impact and Mechanisms
Disease COVID-19    
Immune Y
Target Gene -
Clinical and Epidemiological Correlations
Clinical Information -
Treatment -
Location Switzerland
Literature Information
PMID 33621484
Title Circulating SARS-CoV-2 spike N439K variants maintain fitness while evading antibody-mediated immunity
Author Thomson EC,Rosen LE,Shepherd JG,Spreafico R,da Silva Filipe A,Wojcechowskyj JA,Davis C,Piccoli L,Pascall DJ,Dillen J,Lytras S,Czudnochowski N,Shah R,Meury M,Jesudason N,De Marco A,Li K,Bassi J,O'Toole A,Pinto D,Colquhoun RM,Culap K,Jackson B,Zatta F,Rambaut A,Jaconi S,Sreenu VB,Nix J,Zhang I,Jarrett RF,Glass WG,Beltramello M,Nomikou K,Pizzuto M,Tong L,Cameroni E,Croll TI,Johnson N,Di Iulio J,Wickenhagen A,Ceschi A,Harbison AM,Mair D,Ferrari P,Smollett K,Sallusto F,Carmichael S,Garzoni C,Nichols J,Galli M,Hughes J,Riva A,Ho A,Schiuma M,Semple MG,Openshaw PJM,Fadda E,Baillie JK,Chodera JD,Rihn SJ,Lycett SJ,Virgin HW,Telenti A,Corti D,Robertson DL,Snell G
Journal Cell
Journal Info 2021 Mar 4;184(5):1171-1187
Abstract SARS-CoV-2 can mutate and evade immunity, with consequences for efficacy of emerging vaccines and antibody therapeutics. Here, we demonstrate that the immunodominant SARS-CoV-2 spike (S) receptor binding motif (RBM) is a highly variable region of S and provide epidemiological, clinical, and molecular characterization of a prevalent, sentinel RBM mutation, N439K. We demonstrate N439K S protein has enhanced binding affinity to the hACE2 receptor, and N439K viruses have similar in vitro replication fitness and cause infections with similar clinical outcomes as compared to wild type. We show the N439K mutation confers resistance against several neutralizing monoclonal antibodies, including one authorized for emergency use by the US Food and Drug Administration (FDA), and reduces the activity of some polyclonal sera from persons recovered from infection. Immune evasion mutations that maintain virulence and fitness such as N439K can emerge within SARS-CoV-2 S, highlighting the need for ongoing molecular surveillance to guide development and usage of vaccines and therapeutics.
Sequence Data -
Mutation Information
Note
Basic Characteristics of Mutations
  • Mutation Site: The specific location in a gene or protein sequence where a change occurs.
  • Mutation Level: The level at which a mutation occurs, including the nucleotide or amino acid level.
  • Mutation Type: The nature of the mutation, such as missense mutation, nonsense mutation, synonymous mutation, etc.
  • Gene/Protein/Region: Refers to the specific region of the virus where the mutation occurs. Including viral genes, viral proteins, or a specific viral genome region. If the article does not specifically indicate the relationship between the mutation and its correspondence, the main
  • Gene/Protein/Region studied in the article is marked.
  • Genotype/Subtype: Refers to the viral genotype or subtype where the mutation occurs. If the article does not specifically indicate the relationship between the mutation and its correspondence, the main Genotype/Subtype studied in the article is marked.
  • Viral Reference: Refers to the standard virus strain used to compare and analyze viral sequences.
Functional Impact and Mechanisms
  • Disease: An abnormal physiological state with specific symptoms and signs caused by viral infection.
  • Immune: The article focuses on the study of mutations and immune.
  • Target Gene: Host genes that viral mutations may affect.
Clinical and Epidemiological Correlations
  • Clinical Information: The study is a clinical or epidemiological study and provides basic information about the population.
  • Treatment: The study mentioned a certain treatment method, such as drug resistance caused by mutations. If the study does not specifically indicate the relationship between mutations and their correspondence treatment, the main treatment studied in the article is marked.
  • Location: The source of the research data.
Literature Information
  • Sequence Data: The study provides the data accession number.