HBV Mutation Detail Information

Virus Mutation HBV Mutation P120Q


Basic Characteristics of Mutations
Mutation Site P120Q
Mutation Site Sentence TABLE 1
Mutation Level Amino acid level
Mutation Type Nonsynonymous substitution
Gene/Protein/Region S
Standardized Encoding Gene S  
Genotype/Subtype D;B;F
Viral Reference AB241115;AY233278;AB116079;AY738141;AB194951;AB194952;AM180623;AY934764;FJ692609;FJ692613;GQ331047;GQ331048;AB014366;D00329;AP011084;AY596111;AB219427;AP011085;AP011086;AP011091;AP011093;AP011094;EF473977;M54923;AB073835;AB115551;AB287316;DQ463787;AB031265;AB112066;AB033553;AB368297;AF533983;HQ622095;KU695745;KU695746;X75656;X75665;AB048704;AB048705;KF873543;KF873545;AB241109;AP011099;EU410081;KM999992;KM999993;AP011103;AP011102;EU670263;AP011104;AP011105;AP011106;AP011107;AP011108;AB540583;AB554019;AB554020;AB554018;AB554025;AB644280;AB644281;GQ377555;HM011493;AB644286;AB644287;FJ904424;X80926;AB109475;Z35716;AB493845;AB493846;AY233291;X65257;AB033559;AB048702;AB033558;DQ315779;AM494716;FJ904430;AB091256;HM363610;X75664;AY090459;DQ823095;HM585194;AY090455;DQ899143;X69798;AB036905;AB036915;MH051986;AB166850;DQ823090;KJ843175;AB056513;AB064310;EF634480;AB516395;AY090454;AY090457;FJ023664;FJ023660;AB486012
Functional Impact and Mechanisms
Disease Carcinoma, Hepatocellular    
Immune Y
Target Gene -
Clinical and Epidemiological Correlations
Clinical Information -
Treatment -
Location Western Africa;Northern Europe;Central Asia;Eastern Africa;Caribbean;Eastern Asia;New Zealand;Northern Africa;South-eastern Asia;Australia;Melanesia;South America;North America;Southern Asia;Western Asia;Polynesia;Middle Africa;Central America;Southern Africa;Southern Europe;Western Europe;Eastern Europe
Literature Information
PMID 33381105
Title Comprehensive Analysis of Clinically Significant Hepatitis B Virus Mutations in Relation to Genotype, Subgenotype and Geographic Region
Author Araujo NM,Teles SA,Spitz N
Journal Frontiers in microbiology
Journal Info 2020 Dec 14;11:616023
Abstract Hepatitis B virus (HBV) is a highly variable DNA virus due to its unique life cycle, which involves an error-prone reverse transcriptase. The high substitution rate drives the evolution of HBV by generating genetic variants upon which selection operates. HBV mutants with clinical implications have been documented worldwide, indicating the potential for spreading and developing their own epidemiology. However, the prevalence of such mutants among the different HBV genotypes and subgenotypes has not been systematically analyzed. In the current study, we performed large-scale analysis of 6,479 full-length HBV genome sequences from genotypes A-H, with the aim of gaining comprehensive insights into the relationships of relevant mutations associated with immune escape, antiviral resistance and hepatocellular carcinoma (HCC) development with HBV (sub)genotypes and geographic regions. Immune escape mutations were detected in 10.7% of the sequences, the most common being I/T126S (1.8%), G145R (1.2%), M133T (1.2%), and Q129R (1.0%). HBV genotype B showed the highest rate of escape mutations (14.7%) while genotype H had no mutations (P < 0.001). HCC-associated mutations were detected in 33.7% of the sequences, with significantly higher frequency of C1653T, T1753V and A1762T/G1764A in genotype G than C (P < 0.001). The overall frequencies of lamivudine-, telbivudine-, adefovir-, and entecavir-resistant mutants were 7.3, 7.2, 0.5, and 0.2%, respectively, while only 0.05% showed reduced susceptibility to tenofovir. In particular, the highest frequency of lamivudine-resistant mutations was observed in genotype G and the lowest frequency in genotype E (32.5 and 0.3%; P < 0.001). The prevalence of HBV mutants was also biased by geographic location, with North America identified as one of the regions with the highest rates of immune escape, antiviral resistance, and HCC-associated mutants. The collective findings were discussed in light of natural selection and the known characteristics of HBV (sub)genotypes. Our data provide relevant information on the prevalence of clinically relevant HBV mutations, which may contribute to further improvement of diagnostic procedures, immunization programs, therapeutic protocols, and disease prognosis.
Sequence Data SupplementaryTable1
Mutation Information
Note
Basic Characteristics of Mutations
  • Mutation Site: The specific location in a gene or protein sequence where a change occurs.
  • Mutation Level: The level at which a mutation occurs, including the nucleotide or amino acid level.
  • Mutation Type: The nature of the mutation, such as missense mutation, nonsense mutation, synonymous mutation, etc.
  • Gene/Protein/Region: Refers to the specific region of the virus where the mutation occurs. Including viral genes, viral proteins, or a specific viral genome region. If the article does not specifically indicate the relationship between the mutation and its correspondence, the main
  • Gene/Protein/Region studied in the article is marked.
  • Genotype/Subtype: Refers to the viral genotype or subtype where the mutation occurs. If the article does not specifically indicate the relationship between the mutation and its correspondence, the main Genotype/Subtype studied in the article is marked.
  • Viral Reference: Refers to the standard virus strain used to compare and analyze viral sequences.
Functional Impact and Mechanisms
  • Disease: An abnormal physiological state with specific symptoms and signs caused by viral infection.
  • Immune: The article focuses on the study of mutations and immune.
  • Target Gene: Host genes that viral mutations may affect.
Clinical and Epidemiological Correlations
  • Clinical Information: The study is a clinical or epidemiological study and provides basic information about the population.
  • Treatment: The study mentioned a certain treatment method, such as drug resistance caused by mutations. If the study does not specifically indicate the relationship between mutations and their correspondence treatment, the main treatment studied in the article is marked.
  • Location: The source of the research data.
Literature Information
  • Sequence Data: The study provides the data accession number.