HPV Mutation Detail Information

Virus Mutation HPV Mutation Q123K


Basic Characteristics of Mutations
Mutation Site Q123K
Mutation Site Sentence In addition, 3 novel variants at E6 (Q20P, H118Q, and Q123K) and 2 at E7 (D75N and T86P) were found.
Mutation Level Amino acid level
Mutation Type Nonsynonymous substitution
Gene/Protein/Region E6
Standardized Encoding Gene E6
Genotype/Subtype HPV16
Viral Reference NC_001526
Functional Impact and Mechanisms
Disease Cervical Intraepithelial Neoplasia     Uterine Cervical Neoplasms    
Immune -
Target Gene -
Clinical and Epidemiological Correlations
Clinical Information Y
Treatment -
Location China
Literature Information
PMID 21051983
Title Distribution of human papillomavirus 16 E6/E7 variants in cervical cancer and intraepithelial neoplasia in Chinese women
Author Ding T,Wang X,Ye F,Cheng X,Lu W,Xie X
Journal International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
Journal Info 2010 Nov;20(8):1391-8
Abstract INTRODUCTION: Human papillomavirus (HPV) type 16 is the major etiological agents of cervical cancer. Recently, the studies have demonstrated that HPV intratypic variations could affect oncogenic potential to cervical cancer development. The objectives of this study were to identify HPV-16 E6 and E7 variants prevalent in Chinese women and to assess the risk of them for invasive cervical carcinoma and cervical intraepithelial neoplasia (CIN). METHODS: DNA samples were genotyped by flow-through hybridization (HybriMax) and amplified by using primers specific for E6 and E7. Products were directly sequenced and analyzed using BLAST on PubMed. RESULTS: A total of 170 cervical samples (33 cases of normal control, 11 of CIN 1, 72 of CIN 2-3, and 54 of invasive cervical carcinoma) were HPV-16-positive and were analyzed for E6 and E7 sequence variation. The results showed that HPV-16 Asian lineage was the most frequently detected (77%) and that the Asian variant presented a significantly higher disease risk for cervical cancer and CIN. In addition, 3 novel variants at E6 (Q20P, H118Q, and Q123K) and 2 at E7 (D75N and T86P) were found. The substitution G368T at E6 leading to a premature stop codon occurred in an isolate of normal control sample. CONCLUSIONS: This study reported the distribution of HPV-16 E6 and E7 gene variations in women from southeastern China, which are different from that showed in previous studies and may be important when developing an effective vaccine for this area.
Sequence Data -
Mutation Information
Note
Basic Characteristics of Mutations
  • Mutation Site: The specific location in a gene or protein sequence where a change occurs.
  • Mutation Level: The level at which a mutation occurs, including the nucleotide or amino acid level.
  • Mutation Type: The nature of the mutation, such as missense mutation, nonsense mutation, synonymous mutation, etc.
  • Gene/Protein/Region: Refers to the specific region of the virus where the mutation occurs. Including viral genes, viral proteins, or a specific viral genome region. If the article does not specifically indicate the relationship between the mutation and its correspondence, the main
  • Gene/Protein/Region studied in the article is marked.
  • Genotype/Subtype: Refers to the viral genotype or subtype where the mutation occurs. If the article does not specifically indicate the relationship between the mutation and its correspondence, the main Genotype/Subtype studied in the article is marked.
  • Viral Reference: Refers to the standard virus strain used to compare and analyze viral sequences.
Functional Impact and Mechanisms
  • Disease: An abnormal physiological state with specific symptoms and signs caused by viral infection.
  • Immune: The article focuses on the study of mutations and immune.
  • Target Gene: Host genes that viral mutations may affect.
Clinical and Epidemiological Correlations
  • Clinical Information: The study is a clinical or epidemiological study and provides basic information about the population.
  • Treatment: The study mentioned a certain treatment method, such as drug resistance caused by mutations. If the study does not specifically indicate the relationship between mutations and their correspondence treatment, the main treatment studied in the article is marked.
  • Location: The source of the research data.
Literature Information
  • Sequence Data: The study provides the data accession number.