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Basic Characteristics of Mutations
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Mutation Site
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S139N |
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Mutation Site Sentence
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Here we show that a single serine-to-asparagine substitution [Ser139 Asn139 (S139N)] in the viral polyprotein substantially increased ZIKV infectivity in both human and mouse neural progenitor cells (NPCs) and led to more severe microcephaly in the mouse fetus, as well as higher mortality rates in neonatal mice. |
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Mutation Level
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Amino acid level |
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Mutation Type
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Nonsynonymous substitution |
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Gene/Protein/Region
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prM |
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Standardized Encoding Gene
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prM
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Genotype/Subtype
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- |
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Viral Reference
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-
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Functional Impact and Mechanisms
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Disease
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Microcephaly
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Immune
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- |
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Target Gene
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-
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Clinical and Epidemiological Correlations
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Clinical Information
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- |
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Treatment
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- |
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Location
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- |
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Literature Information
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PMID
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28971967
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Title
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A single mutation in the prM protein of Zika virus contributes to fetal microcephaly
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Author
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Yuan L,Huang XY,Liu ZY,Zhang F,Zhu XL,Yu JY,Ji X,Xu YP,Li G,Li C,Wang HJ,Deng YQ,Wu M,Cheng ML,Ye Q,Xie DY,Li XF,Wang X,Shi W,Hu B,Shi PY,Xu Z,Qin CF
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Journal
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Science (New York, N.Y.)
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Journal Info
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2017 Nov 17;358(6365):933-936
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Abstract
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Zika virus (ZIKV) has evolved into a global health threat because of its unexpected causal link to microcephaly. Phylogenetic analysis reveals that contemporary epidemic strains have accumulated multiple substitutions from their Asian ancestor. Here we show that a single serine-to-asparagine substitution [Ser(139)-->Asn(139) (S139N)] in the viral polyprotein substantially increased ZIKV infectivity in both human and mouse neural progenitor cells (NPCs) and led to more severe microcephaly in the mouse fetus, as well as higher mortality rates in neonatal mice. Evolutionary analysis indicates that the S139N substitution arose before the 2013 outbreak in French Polynesia and has been stably maintained during subsequent spread to the Americas. This functional adaption makes ZIKV more virulent to human NPCs, thus contributing to the increased incidence of microcephaly in recent ZIKV epidemics.
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Sequence Data
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-
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