HPV Mutation Detail Information

Virus Mutation HPV Mutation S189T


Basic Characteristics of Mutations
Mutation Site S189T
Mutation Site Sentence Two samples of HPV 54 (samples 320 and 465) had the same aa substitutions: S189T (EF loop), D270E (FG loop) and L280P (FG loop).
Mutation Level Amino acid level
Mutation Type Nonsynonymous substitution
Gene/Protein/Region L1
Standardized Encoding Gene L1
Genotype/Subtype HPV54
Viral Reference -
Functional Impact and Mechanisms
Disease HPV-HIV Coinfection    
Immune -
Target Gene -
Clinical and Epidemiological Correlations
Clinical Information Y
Treatment -
Location Brazil
Literature Information
PMID 40105445
Title Intratype variants and high genotypic diversity of human papillomavirus with polymorphisms in the antigenic hypervariable loops of the L1 protein from women living with human immunodeficiency virus in Northeastern Brazil
Author Vieira Alves M,Oliveira Pereira G,Alves Dos Santos Silva L,Doria Araujo E,Barreto da Silva BE,Dolce de Lemos LM,de Aragao Batista MV
Journal Journal of medical microbiology
Journal Info 2025 Mar;74(3):001981
Abstract Introduction. The human papillomavirus (HPV) is one of the main oncogenic viruses. High-risk HPV types are associated with the development of cervical cancers. In addition, it is known that some mutations in HPV genes, or variant viral lineages, have been associated with greater oncogenic risk.Gap statement. The L1 protein is the major component of the viral capsid and is therefore used in currently available vaccines. However, the characterization of mutations in the L1 gene, which is relevant to increasing the knowledge of the immune escape mechanisms used by the virus, is still incipient.Aim. This study aimed to characterize mutations associated with antigenic domains in the L1 protein of HPVs isolated from cervical samples of women living with HIV in Northeastern Brazil.Methodology. L1 gene sequences were obtained from the samples, and the mutations and the viral variants were characterized. Phylogenetic and functional analyses of the structure of the L1 protein were carried out.Results. A total of 41 HPV variant isolates were obtained, distributed among 16 different viral types. Of this, 25 non-synonymous mutations were evaluated regarding the stability of the L1 protein. It was observed that 10 of these mutations were predicted to increase, and 14 to decrease, the stability of the L1 protein and that most of them occurred in the FG hypervariable antigenic loop.Conclusion. These results add useful knowledge to understanding the biological and immunological aspects of HPV variants and the impact of these mutations on the development of vaccine strategies.
Sequence Data PP972021-PP972061
Mutation Information
Note
Basic Characteristics of Mutations
  • Mutation Site: The specific location in a gene or protein sequence where a change occurs.
  • Mutation Level: The level at which a mutation occurs, including the nucleotide or amino acid level.
  • Mutation Type: The nature of the mutation, such as missense mutation, nonsense mutation, synonymous mutation, etc.
  • Gene/Protein/Region: Refers to the specific region of the virus where the mutation occurs. Including viral genes, viral proteins, or a specific viral genome region. If the article does not specifically indicate the relationship between the mutation and its correspondence, the main
  • Gene/Protein/Region studied in the article is marked.
  • Genotype/Subtype: Refers to the viral genotype or subtype where the mutation occurs. If the article does not specifically indicate the relationship between the mutation and its correspondence, the main Genotype/Subtype studied in the article is marked.
  • Viral Reference: Refers to the standard virus strain used to compare and analyze viral sequences.
Functional Impact and Mechanisms
  • Disease: An abnormal physiological state with specific symptoms and signs caused by viral infection.
  • Immune: The article focuses on the study of mutations and immune.
  • Target Gene: Host genes that viral mutations may affect.
Clinical and Epidemiological Correlations
  • Clinical Information: The study is a clinical or epidemiological study and provides basic information about the population.
  • Treatment: The study mentioned a certain treatment method, such as drug resistance caused by mutations. If the study does not specifically indicate the relationship between mutations and their correspondence treatment, the main treatment studied in the article is marked.
  • Location: The source of the research data.
Literature Information
  • Sequence Data: The study provides the data accession number.