HTLV1 Mutation Detail Information

Virus Mutation HTLV1 Mutation S246Y


Basic Characteristics of Mutations
Mutation Site S246Y
Mutation Site Sentence The potential protein domain analysis of Env sequences showed the loss of a CK-2 phosphorylation site caused by D197N mutation in one epitope, and a N-glycosylation site caused by S246Y and V247I mutations in another epitope.
Mutation Level Amino acid level
Mutation Type Nonsynonymous substitution
Gene/Protein/Region env
Standardized Encoding Gene env  
Genotype/Subtype -
Viral Reference ATK1 reference strain
Functional Impact and Mechanisms
Disease HTLV-1 Infection    
Immune Y
Target Gene -
Clinical and Epidemiological Correlations
Clinical Information -
Treatment -
Location Brazil
Literature Information
PMID 17924005
Title Mapping the molecular characteristics of Brazilian human T-cell lymphotropic virus type 1 Env (gp46) and Pol amino acid sequences for vaccine design
Author Mota-Miranda AC,de-Oliveira T,Moreau DR,Bomfim C,Galvao-Castro B,Alcantara LC Jr
Journal Memorias do Instituto Oswaldo Cruz
Journal Info 2007 Sep;102(6):741-9
Abstract This study was carried out to evaluate the molecular pattern of all available Brazilian human T-cell lymphotropic virus type 1 Env (n = 15) and Pol (n = 43) nucleotide sequences via epitope prediction, physico-chemical analysis, and protein potential sites identification, giving support to the Brazilian AIDS vaccine program. In 12 previously described peptides of the Env sequences we found 12 epitopes, while in 4 peptides of the Pol sequences we found 4 epitopes. The total variation on the amino acid composition was 9 and 17% for human leukocyte antigen (HLA) class I and class II Env epitopes, respectively. After analyzing the Pol sequences, results revealed a total amino acid variation of 0.75% for HLA-I and HLA-II epitopes. In 5 of the 12 Env epitopes the physico-chemical analysis demonstrated that the mutations magnified the antigenicity profile. The potential protein domain analysis of Env sequences showed the loss of a CK-2 phosphorylation site caused by D197N mutation in one epitope, and a N-glycosylation site caused by S246Y and V247I mutations in another epitope. Besides, the analysis of selection pressure have found 8 positive selected sites (w = 9.59) using the codon-based substitution models and maximum-likelihood methods. These studies underscore the importance of this Env region for the virus fitness, for the host immune response and, therefore, for the development of vaccine candidates.
Sequence Data U81869;U81865;U81866;U81867;U81868;DQ007198;DQ007197;DQ007194;DQ007191;DQ007197;DQ007193;DQ007158;DQ007189;DQ007190;DQ007195;AF197327;AF197326;AF197325;AF197324;AF197323;AF197322;AF197321;AF197320;AF197319;AF197318;AF197317;AF197316;AF197315;AF197314;AF197313;AF197312;AF197311;AF197310;AF197309;AF197308;AF197307;AF197306;AF197305;AF197304;AF197303;AF197302;AF197301;AF197300;AF197299;AF197298;AF197297;AF197296;AF197295;AF197294;AF197293;AF197292;AF197291;AF197290;AF197289;AF197288;AF197287;AF197286;AF197285
Mutation Information
Note
Basic Characteristics of Mutations
  • Mutation Site: The specific location in a gene or protein sequence where a change occurs.
  • Mutation Level: The level at which a mutation occurs, including the nucleotide or amino acid level.
  • Mutation Type: The nature of the mutation, such as missense mutation, nonsense mutation, synonymous mutation, etc.
  • Gene/Protein/Region: Refers to the specific region of the virus where the mutation occurs. Including viral genes, viral proteins, or a specific viral genome region. If the article does not specifically indicate the relationship between the mutation and its correspondence, the main
  • Gene/Protein/Region studied in the article is marked.
  • Genotype/Subtype: Refers to the viral genotype or subtype where the mutation occurs. If the article does not specifically indicate the relationship between the mutation and its correspondence, the main Genotype/Subtype studied in the article is marked.
  • Viral Reference: Refers to the standard virus strain used to compare and analyze viral sequences.
Functional Impact and Mechanisms
  • Disease: An abnormal physiological state with specific symptoms and signs caused by viral infection.
  • Immune: The article focuses on the study of mutations and immune.
  • Target Gene: Host genes that viral mutations may affect.
Clinical and Epidemiological Correlations
  • Clinical Information: The study is a clinical or epidemiological study and provides basic information about the population.
  • Treatment: The study mentioned a certain treatment method, such as drug resistance caused by mutations. If the study does not specifically indicate the relationship between mutations and their correspondence treatment, the main treatment studied in the article is marked.
  • Location: The source of the research data.
Literature Information
  • Sequence Data: The study provides the data accession number.