SARS-CoV-2 Mutation Detail Information

Virus Mutation SARS-CoV-2 Mutation S477N


Basic Characteristics of Mutations
Mutation Site S477N
Mutation Site Sentence We here describe a SARS-CoV-2 lineage - designated B.1.620 - discovered in Lithuania and carrying many mutations and deletions in the spike protein shared with widespread variants of concern (VOCs), including E484K, S477N and deletions HV69Delta, Y144Delta, and LLA241/243Delta.
Mutation Level Amino acid level
Mutation Type Nonsynonymous substitution
Gene/Protein/Region S
Standardized Encoding Gene S  
Genotype/Subtype B.1.620
Viral Reference NC_045512
Functional Impact and Mechanisms
Disease COVID-19    
Immune Y
Target Gene -
Clinical and Epidemiological Correlations
Clinical Information -
Treatment -
Location Lithuania
Literature Information
PMID 34599175
Title Emergence and spread of SARS-CoV-2 lineage B.1.620 with variant of concern-like mutations and deletions
Author Dudas G,Hong SL,Potter BI,Calvignac-Spencer S,Niatou-Singa FS,Tombolomako TB,Fuh-Neba T,Vickos U,Ulrich M,Leendertz FH,Khan K,Huber C,Watts A,Olendraite I,Snijder J,Wijnant KN,Bonvin AMJJ,Martres P,Behillil S,Ayouba A,Maidadi MF,Djomsi DM,Godwe C,Butel C,Simaitis A,Gabrielaite M,Katenaite M,Norvilas R,Raugaite L,Koyaweda GW,Kandou JK,Jonikas R,Nasvytiene I,Zemeckiene Z,Gecys D,Tamusauskaite K,Norkiene M,Vasiliunaite E,Ziogiene D,Timinskas A,Sukys M,Sarauskas M,Alzbutas G,Aziza AA,Lusamaki EK,Cigolo JM,Mawete FM,Lofiko EL,Kingebeni PM,Tamfum JM,Belizaire MRD,Essomba RG,Assoumou MCO,Mboringong AB,Dieng AB,Juozapaite D,Hosch S,Obama J,Ayekaba MO,Naumovas D,Pautienius A,Rafai CD,Vitkauskiene A,Ugenskiene R,Gedvilaite A,Cereskevicius D,Lesauskaite V,Zemaitis L,Griskevicius L,Baele G
Journal Nature communications
Journal Info 2021 Oct 1;12(1):5769
Abstract Distinct SARS-CoV-2 lineages, discovered through various genomic surveillance initiatives, have emerged during the pandemic following unprecedented reductions in worldwide human mobility. We here describe a SARS-CoV-2 lineage - designated B.1.620 - discovered in Lithuania and carrying many mutations and deletions in the spike protein shared with widespread variants of concern (VOCs), including E484K, S477N and deletions HV69Delta, Y144Delta, and LLA241/243Delta. As well as documenting the suite of mutations this lineage carries, we also describe its potential to be resistant to neutralising antibodies, accompanying travel histories for a subset of European cases, evidence of local B.1.620 transmission in Europe with a focus on Lithuania, and significance of its prevalence in Central Africa owing to recent genome sequencing efforts there. We make a case for its likely Central African origin using advanced phylogeographic inference methodologies incorporating recorded travel histories of infected travellers.
Sequence Data -
Mutation Information
Note
Basic Characteristics of Mutations
  • Mutation Site: The specific location in a gene or protein sequence where a change occurs.
  • Mutation Level: The level at which a mutation occurs, including the nucleotide or amino acid level.
  • Mutation Type: The nature of the mutation, such as missense mutation, nonsense mutation, synonymous mutation, etc.
  • Gene/Protein/Region: Refers to the specific region of the virus where the mutation occurs. Including viral genes, viral proteins, or a specific viral genome region. If the article does not specifically indicate the relationship between the mutation and its correspondence, the main
  • Gene/Protein/Region studied in the article is marked.
  • Genotype/Subtype: Refers to the viral genotype or subtype where the mutation occurs. If the article does not specifically indicate the relationship between the mutation and its correspondence, the main Genotype/Subtype studied in the article is marked.
  • Viral Reference: Refers to the standard virus strain used to compare and analyze viral sequences.
Functional Impact and Mechanisms
  • Disease: An abnormal physiological state with specific symptoms and signs caused by viral infection.
  • Immune: The article focuses on the study of mutations and immune.
  • Target Gene: Host genes that viral mutations may affect.
Clinical and Epidemiological Correlations
  • Clinical Information: The study is a clinical or epidemiological study and provides basic information about the population.
  • Treatment: The study mentioned a certain treatment method, such as drug resistance caused by mutations. If the study does not specifically indicate the relationship between mutations and their correspondence treatment, the main treatment studied in the article is marked.
  • Location: The source of the research data.
Literature Information
  • Sequence Data: The study provides the data accession number.