DENV Mutation Detail Information

Virus Mutation DENV Mutation T10407C


Basic Characteristics of Mutations
Mutation Site T10407C
Mutation Site Sentence Although the maximum mutations were observed in the NS5 region that correlated with both TRDV and TRGV, one mutation, in particular T10407C, was positively and significantly correlated with both TRDV and TRGV in the severe patients only.
Mutation Level Nucleotide level
Mutation Type
Gene/Protein/Region 3'UTR
Standardized Encoding Gene
Genotype/Subtype DENV-2
Viral Reference NC_001474
Functional Impact and Mechanisms
Disease Dengue    
Immune -
Target Gene -
Clinical and Epidemiological Correlations
Clinical Information -
Treatment -
Location -
Literature Information
PMID 39403197
Title TCR repertoire dynamics and their responses underscores dengue severity
Author Khare K,Yadav S,Tarai B,Budhiraja S,Pandey R
Journal iScience
Journal Info 2024 Sep 16;27(10):110983
Abstract Despite recognizing the immune response's role in dengue progression, the intricate dynamics of T cell receptor (TCR) variations across DENV infection severities remain elusive. This study addresses this gap by analyzing in-house generated RNA-seq data from 112 dengue patients with varying disease severities. Our findings reveal that severe dengue patients exhibit pronounced clinical manifestations including leukopenia, thrombocytopenia, and elevated lymphocyte levels, Intriguingly, these patients also showed increased diversity in gamma and delta TCR chains, unique TRGV and TRBV segment usage, and extended delta-CDR3 sequences, suggesting specialized inflammatory functions. Furthermore, mutations in the NS5 and 3'UTR regions of the dengue genome correlated with increased TRDV and TRGV chains, indicating a significant role for these mutations in the prevalence of specific TCR chains during severe infections. Overall, the study highlights the complex role of TCR repertoire in dengue pathogenesis, enhancing our understanding of TCR dynamics for future infectious diseases.
Sequence Data -
Mutation Information
Note
Basic Characteristics of Mutations
  • Mutation Site: The specific location in a gene or protein sequence where a change occurs.
  • Mutation Level: The level at which a mutation occurs, including the nucleotide or amino acid level.
  • Mutation Type: The nature of the mutation, such as missense mutation, nonsense mutation, synonymous mutation, etc.
  • Gene/Protein/Region: Refers to the specific region of the virus where the mutation occurs. Including viral genes, viral proteins, or a specific viral genome region. If the article does not specifically indicate the relationship between the mutation and its correspondence, the main
  • Gene/Protein/Region studied in the article is marked.
  • Genotype/Subtype: Refers to the viral genotype or subtype where the mutation occurs. If the article does not specifically indicate the relationship between the mutation and its correspondence, the main Genotype/Subtype studied in the article is marked.
  • Viral Reference: Refers to the standard virus strain used to compare and analyze viral sequences.
Functional Impact and Mechanisms
  • Disease: An abnormal physiological state with specific symptoms and signs caused by viral infection.
  • Immune: The article focuses on the study of mutations and immune.
  • Target Gene: Host genes that viral mutations may affect.
Clinical and Epidemiological Correlations
  • Clinical Information: The study is a clinical or epidemiological study and provides basic information about the population.
  • Treatment: The study mentioned a certain treatment method, such as drug resistance caused by mutations. If the study does not specifically indicate the relationship between mutations and their correspondence treatment, the main treatment studied in the article is marked.
  • Location: The source of the research data.
Literature Information
  • Sequence Data: The study provides the data accession number.