SARS-CoV-2 Mutation Detail Information

Virus Mutation SARS-CoV-2 Mutation T17459C


Basic Characteristics of Mutations
Mutation Site T17459C
Mutation Site Sentence The other two (hCoV-19/Singapore/12/2020 and hCoV-19/Singapore/13/2020) each additionally showed two different non-synonymous mutations S-T2449C (F817L) and ORF3a-C176A (A59D),and ORF1ab-T17459C (V5820A) and N-C595T (P199S),respectively.
Mutation Level Nucleotide level
Mutation Type Nonsynonymous substitution
Gene/Protein/Region ORF1ab
Standardized Encoding Gene ORF1ab  
Genotype/Subtype -
Viral Reference MN908947.3
Functional Impact and Mechanisms
Disease COVID-19    
Immune -
Target Gene -
Clinical and Epidemiological Correlations
Clinical Information -
Treatment -
Location Taiwan
Literature Information
PMID 32543353
Title SARS-CoV-2 genomic surveillance in Taiwan revealed novel ORF8-deletion mutant and clade possibly associated with infections in Middle East
Author Gong YN,Tsao KC,Hsiao MJ,Huang CG,Huang PN,Huang PW,Lee KM,Liu YC,Yang SL,Kuo RL,Chen KF,Liu YC,Huang SY,Huang HI,Liu MT,Yang JR,Chiu CH,Yang CT,Chen GW,Shih SR
Journal Emerging microbes & infections
Journal Info 2020 Dec;9(1):1457-1466
Abstract Taiwan experienced two waves of imported infections with Coronavirus Disease 2019 (COVID-19). This study aimed at investigating the genomic variation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in Taiwan and compared their evolutionary trajectories with the global strains. We performed culture and full-genome sequencing of SARS-CoV-2 strains followed by phylogenetic analysis. A 382-nucleotides deletion in open reading frame 8 (ORF8) was found in a Taiwanese strain isolated from a patient on February 4, 2020 who had a travel history to Wuhan. Patients in the first wave also included several sporadic, local transmission cases. Genomes of 5 strains sequenced from clustered infections were classified into a new clade with ORF1ab-V378I mutation, in addition to 3 dominant clades ORF8-L84S, ORF3a-G251V and S-D614G. This highlighted clade also included some strains isolated from patients who had a travel history to Turkey and Iran. The second wave mostly resulted from patients who had a travel history to Europe and Americas. All Taiwanese viruses were classified into various clades. Genomic surveillance of SARS-CoV-2 in Taiwan revealed a new ORF8-deletion mutant and a virus clade that may be associated with infections in the Middle East, which contributed to a better understanding of the global SARS-CoV-2 transmission dynamics.
Sequence Data EPI_ISL_411915;EPI_ISL_417518;EPI_ISL_415741;EPI_ISL_415742;EPI_ISL_415743;EPI_ISL_417519;EPI_ISL_417520;EPI_ISL_417521;EPI_ISL_417522;EPI_ISL_417523;EPI_ISL_417524;EPI_ISL_417525;EPI_ISL_424969;EPI_ISL_424970;EPI_ISL_424971;EPI_ISL_424972;EPI_ISL_424973;EPI_ISL_424974;EPI_ISL_424975;EPI_ISL_424978
Mutation Information
Note
Basic Characteristics of Mutations
  • Mutation Site: The specific location in a gene or protein sequence where a change occurs.
  • Mutation Level: The level at which a mutation occurs, including the nucleotide or amino acid level.
  • Mutation Type: The nature of the mutation, such as missense mutation, nonsense mutation, synonymous mutation, etc.
  • Gene/Protein/Region: Refers to the specific region of the virus where the mutation occurs. Including viral genes, viral proteins, or a specific viral genome region. If the article does not specifically indicate the relationship between the mutation and its correspondence, the main
  • Gene/Protein/Region studied in the article is marked.
  • Genotype/Subtype: Refers to the viral genotype or subtype where the mutation occurs. If the article does not specifically indicate the relationship between the mutation and its correspondence, the main Genotype/Subtype studied in the article is marked.
  • Viral Reference: Refers to the standard virus strain used to compare and analyze viral sequences.
Functional Impact and Mechanisms
  • Disease: An abnormal physiological state with specific symptoms and signs caused by viral infection.
  • Immune: The article focuses on the study of mutations and immune.
  • Target Gene: Host genes that viral mutations may affect.
Clinical and Epidemiological Correlations
  • Clinical Information: The study is a clinical or epidemiological study and provides basic information about the population.
  • Treatment: The study mentioned a certain treatment method, such as drug resistance caused by mutations. If the study does not specifically indicate the relationship between mutations and their correspondence treatment, the main treatment studied in the article is marked.
  • Location: The source of the research data.
Literature Information
  • Sequence Data: The study provides the data accession number.