HPV Mutation Detail Information

Virus Mutation HPV Mutation T178G


Basic Characteristics of Mutations
Mutation Site T178G
Mutation Site Sentence RESULTS: Compared with the European-Germanyl31 (EG131), 20 mutations were detected, of which eight mutations were detected from all the four biopsies: 131(G-A)(Gly-Arg), 178 (T-G)(Asp-Glu),350 (G-T)(Val-Leu), 647 (A-G)(Asn-Asp),846 (T-C) (synonymous mutation), L1 966th (C-T)(synonymous mutation),L1 1302 (C-T)(synonymous mutation) and L1 1434th (A-G) (synonymous mutation).
Mutation Level Nucleotide level
Mutation Type Nonsynonymous substitution
Gene/Protein/Region
Standardized Encoding Gene
Genotype/Subtype HPV16
Viral Reference -
Functional Impact and Mechanisms
Disease Uterine Cervical Neoplasms    
Immune -
Target Gene -
Clinical and Epidemiological Correlations
Clinical Information -
Treatment -
Location China
Literature Information
PMID 24601042
Title Research on sequence variations analysis of HPV-16 type in Southwestern China
Author Wang Y,Ding X,Zhu Y
Journal European journal of gynaecological oncology
Journal Info 2013;34(6):518-21
Abstract OBJECTIVE: This study was designed to analyze sequence variations in E6, E7, and L1 of human papillomavirus type 16 (HPV-16) to identify novel HPV-6 variants and correlate them with the progression of cervical cancer. MATERIALS AND METHODS: Cervical biopsies from 12 HPV-16 positive cervical neoplasia cases were analyzed by polymerase chain reaction (PCR) for E6,E7, and L1 gene. The products of PCR were ligated into pGEM-T vector and used to transform e. coli DH5a. Finally, the sequence of the insert was determined by an automated DNA sequencer. RESULTS: Compared with the European-Germanyl31 (EG131), 20 mutations were detected, of which eight mutations were detected from all the four biopsies: 131(G-A)(Gly-Arg), 178 (T-G)(Asp-Glu),350 (G-T)(Val-Leu), 647 (A-G)(Asn-Asp),846 (T-C) (synonymous mutation), L1 966th (C-T)(synonymous mutation),L1 1302 (C-T)(synonymous mutation) and L1 1434th (A-G) (synonymous mutation). CONCLUSIONS: Compared with other HPV-16 reference sequences, nucleotide sequencing analysis of the HPV-16, E6,E7, and L1 gene from cervical carcinoma biopses in Southwestern China consistently shows point mutations, including synonymous mutation and nonsynonymous mutation. Above all, the results may have implications for future researches of viral persistence, transmission, oncogenic potential, developing diagnostic probe, and designing vaccine or biological preparation for a particular population.
Sequence Data -
Mutation Information
Note
Basic Characteristics of Mutations
  • Mutation Site: The specific location in a gene or protein sequence where a change occurs.
  • Mutation Level: The level at which a mutation occurs, including the nucleotide or amino acid level.
  • Mutation Type: The nature of the mutation, such as missense mutation, nonsense mutation, synonymous mutation, etc.
  • Gene/Protein/Region: Refers to the specific region of the virus where the mutation occurs. Including viral genes, viral proteins, or a specific viral genome region. If the article does not specifically indicate the relationship between the mutation and its correspondence, the main
  • Gene/Protein/Region studied in the article is marked.
  • Genotype/Subtype: Refers to the viral genotype or subtype where the mutation occurs. If the article does not specifically indicate the relationship between the mutation and its correspondence, the main Genotype/Subtype studied in the article is marked.
  • Viral Reference: Refers to the standard virus strain used to compare and analyze viral sequences.
Functional Impact and Mechanisms
  • Disease: An abnormal physiological state with specific symptoms and signs caused by viral infection.
  • Immune: The article focuses on the study of mutations and immune.
  • Target Gene: Host genes that viral mutations may affect.
Clinical and Epidemiological Correlations
  • Clinical Information: The study is a clinical or epidemiological study and provides basic information about the population.
  • Treatment: The study mentioned a certain treatment method, such as drug resistance caused by mutations. If the study does not specifically indicate the relationship between mutations and their correspondence treatment, the main treatment studied in the article is marked.
  • Location: The source of the research data.
Literature Information
  • Sequence Data: The study provides the data accession number.