HBV Mutation Detail Information

Virus Mutation HBV Mutation T1803A


Basic Characteristics of Mutations
Mutation Site T1803A
Mutation Site Sentence Other mutations in descending order by mutation rate were a: A1762T/G1764A combined mutation (90. 48%); G1756C/T1803A/A(1757 ~ 1765)/A (1824 ~ 1832) combined mutation (80. 95%); T1753C/A1762T/ G1764A combined mutation (57. 14%); A1762T/G1764A/G1896A combined mutation (42. 86%); G1756C/Δ(1757~176.5) combined mutation,(28. 57%); T1753C/A1762T/G1764A/G1896A combined mutation (23. 81%).
Mutation Level Nucleotide level
Mutation Type
Gene/Protein/Region BCP;PreC
Standardized Encoding Gene C  
Genotype/Subtype -
Viral Reference -
Functional Impact and Mechanisms
Disease Hepatitis B Virus Infection     Carcinoma, Hepatocellular    
Immune -
Target Gene -
Clinical and Epidemiological Correlations
Clinical Information -
Treatment -
Location China
Literature Information
PMID 30702819
Title Analyses of the Genetic Diversities and Mutations of the Hepatitis B Virus Genome BCP/Pre C Region
Author Shu Y,Wang W,Dai P,Zhang W,Cheng S,Li D,Ji Q,Qiu R,Liu H,Zhao W,Yan Z
Journal Bing du xue bao = Chinese journal of virology
Journal Info 2017 Jan;33(1):36-43
Abstract We wished to study the genetic diversities and mutations of the basic core promoter (BCP) and pre-C region of the hepatitis B virus (HBV) in liver-cancer tissues. One hundred and ninety-two tissue samples were collected from patients suffering from hepatocellular carcinoma (HCC) and HBV infection in 2015 in Xijing Hospital. Twenty-one cases were selected, of which direct sequencing of the polymerase chain reaction (PCR)-amplified products of BCP/pre-C region was unsuccessful. Cloning and sequencing allowed the DNA sequences of the BCP/pre-C region to be analyzed. Sequencing showed infection with mixed mutants of HBV in 37. 89% of HBV-positive HCC patients, and that HBV DNA in each sample contained 2 ~ 11 types of mutations.. The mutation rate of deletion and insertion was 80. 95%. Other mutations in descending order by mutation rate were a: A1762T/G1764A combined mutation (90. 48%); G1756C/T1803A/A(1757 ~ 1765)/A (1824 ~ 1832) combined mutation (80. 95%); T1753C/A1762T/ G1764A combined mutation (57. 14%); A1762T/G1764A/G1896A combined mutation (42. 86%); G1756C/Delta(1757~176.5) combined mutation,(28. 57%); T1753C/A1762T/G1764A/G1896A combined mutation (23. 81%). The sequencing failure of PCR products may have been correlated directly with the deletion and insertion mutations of HBV DNA. These findings lay the foundation for further studies on HBV mutations, persistent infection, and the mechanism of personalized medicine.
Sequence Data -
Mutation Information
Note
Basic Characteristics of Mutations
  • Mutation Site: The specific location in a gene or protein sequence where a change occurs.
  • Mutation Level: The level at which a mutation occurs, including the nucleotide or amino acid level.
  • Mutation Type: The nature of the mutation, such as missense mutation, nonsense mutation, synonymous mutation, etc.
  • Gene/Protein/Region: Refers to the specific region of the virus where the mutation occurs. Including viral genes, viral proteins, or a specific viral genome region. If the article does not specifically indicate the relationship between the mutation and its correspondence, the main
  • Gene/Protein/Region studied in the article is marked.
  • Genotype/Subtype: Refers to the viral genotype or subtype where the mutation occurs. If the article does not specifically indicate the relationship between the mutation and its correspondence, the main Genotype/Subtype studied in the article is marked.
  • Viral Reference: Refers to the standard virus strain used to compare and analyze viral sequences.
Functional Impact and Mechanisms
  • Disease: An abnormal physiological state with specific symptoms and signs caused by viral infection.
  • Immune: The article focuses on the study of mutations and immune.
  • Target Gene: Host genes that viral mutations may affect.
Clinical and Epidemiological Correlations
  • Clinical Information: The study is a clinical or epidemiological study and provides basic information about the population.
  • Treatment: The study mentioned a certain treatment method, such as drug resistance caused by mutations. If the study does not specifically indicate the relationship between mutations and their correspondence treatment, the main treatment studied in the article is marked.
  • Location: The source of the research data.
Literature Information
  • Sequence Data: The study provides the data accession number.