DENV Mutation Detail Information

Virus Mutation DENV Mutation T365I


Basic Characteristics of Mutations
Mutation Site T365I
Mutation Site Sentence The analysis of the 142 E gene sequences included in this study revealed 79 aa mutated sites, of which one aa substitution (T365I) was specifically encountered within the Oceania group and another (V287I) was only found in the PF80s group (Table 4).
Mutation Level Amino acid level
Mutation Type Nonsynonymous substitution
Gene/Protein/Region E
Standardized Encoding Gene Envelope
Genotype/Subtype DENV-4
Viral Reference EU448462
Functional Impact and Mechanisms
Disease Dengue    
Immune -
Target Gene -
Clinical and Epidemiological Correlations
Clinical Information -
Treatment -
Location France
Literature Information
PMID 22216313
Title Recent emergence of dengue virus serotype 4 in French Polynesia results from multiple introductions from other South Pacific Islands
Author Cao-Lormeau VM,Roche C,Aubry M,Teissier A,Lastere S,Daudens E,Mallet HP,Musso D,Aaskov J
Journal PloS one
Journal Info 2011;6(12):e29555
Abstract BACKGROUND: Infection by dengue virus (DENV) is a major public health concern in hundreds of tropical and subtropical countries. French Polynesia (FP) regularly experiences epidemics that initiate, or are consecutive to, DENV circulation in other South Pacific Island Countries (SPICs). In January 2009, after a decade of serotype 1 (DENV-1) circulation, the first cases of DENV-4 infection were reported in FP. Two months later a new epidemic emerged, occurring about 20 years after the previous circulation of DENV-4 in FP. In this study, we investigated the epidemiological and molecular characteristics of the introduction, spread and genetic microevolution of DENV-4 in FP. METHODOLOGY/PRINCIPAL FINDINGS: Epidemiological data suggested that recent transmission of DENV-4 in FP started in the Leeward Islands and this serotype quickly displaced DENV-1 throughout FP. Phylogenetic analyses of the nucleotide sequences of the envelope (E) gene of 64 DENV-4 strains collected in FP in the 1980s and in 2009-2010, and some additional strains from other SPICs showed that DENV-4 strains from the SPICs were distributed into genotypes IIa and IIb. Recent FP strains were distributed into two clusters, each comprising viruses from other but distinct SPICs, suggesting that emergence of DENV-4 in FP in 2009 resulted from multiple introductions. Otherwise, we observed that almost all strains collected in the SPICs in the 1980s exhibit an amino acid (aa) substitution V287I within domain I of the E protein, and all recent South Pacific strains exhibit a T365I substitution within domain III. CONCLUSIONS/SIGNIFICANCE: This study confirmed the cyclic re-emergence and displacement of DENV serotypes in FP. Otherwise, our results showed that specific aa substitutions on the E protein were present on all DENV-4 strains circulating in SPICs. These substitutions probably acquired and subsequently conserved could reflect a founder effect to be associated with epidemiological, geographical, eco-biological and social specificities in SPICs.
Sequence Data JN832498;JN832499;JN832507;JN832500;JN832501;JN832502;JN832503;JN832504;JN832505;JN832514;JN832519;JN832520;JN832521;JN832524;JN832530;JN832536;JN832541;JN832545;JN832546;JN832547;JN832548;JN832551;JN832552;JN832554;JN832555;JN832556;JN832557;JN832558;JN832559;JN832560;JN832561;JN832512;JN832543;JN832550;JN832553;JN832516;JN832526;JN832531;JN832535;JN832542;JN832509;JN832517;JN832518;JN832533;JN832544;JN832508;JN832511;JN832513;JN832515;JN832527;JN832532;JN832537;JN832506;JN832510;JN832522;JN832523;JN832549;JN832534;JN832525;JN832528;JN832538;JN832529;JN832540;JN832539
Mutation Information
Note
Basic Characteristics of Mutations
  • Mutation Site: The specific location in a gene or protein sequence where a change occurs.
  • Mutation Level: The level at which a mutation occurs, including the nucleotide or amino acid level.
  • Mutation Type: The nature of the mutation, such as missense mutation, nonsense mutation, synonymous mutation, etc.
  • Gene/Protein/Region: Refers to the specific region of the virus where the mutation occurs. Including viral genes, viral proteins, or a specific viral genome region. If the article does not specifically indicate the relationship between the mutation and its correspondence, the main
  • Gene/Protein/Region studied in the article is marked.
  • Genotype/Subtype: Refers to the viral genotype or subtype where the mutation occurs. If the article does not specifically indicate the relationship between the mutation and its correspondence, the main Genotype/Subtype studied in the article is marked.
  • Viral Reference: Refers to the standard virus strain used to compare and analyze viral sequences.
Functional Impact and Mechanisms
  • Disease: An abnormal physiological state with specific symptoms and signs caused by viral infection.
  • Immune: The article focuses on the study of mutations and immune.
  • Target Gene: Host genes that viral mutations may affect.
Clinical and Epidemiological Correlations
  • Clinical Information: The study is a clinical or epidemiological study and provides basic information about the population.
  • Treatment: The study mentioned a certain treatment method, such as drug resistance caused by mutations. If the study does not specifically indicate the relationship between mutations and their correspondence treatment, the main treatment studied in the article is marked.
  • Location: The source of the research data.
Literature Information
  • Sequence Data: The study provides the data accession number.