SARS-CoV-2 Mutation Detail Information

Virus Mutation SARS-CoV-2 Mutation T492I


Basic Characteristics of Mutations
Mutation Site T492I
Mutation Site Sentence Four amino acid changes showed significant positive selection: P141S (Nsp3), T492I (Nsp4), P681H (S), and T732A (S) (Table 1).
Mutation Level Amino acid level
Mutation Type Nonsynonymous substitution
Gene/Protein/Region NSP4
Standardized Encoding Gene ORF1a  
Genotype/Subtype -
Viral Reference NC_045512.2
Functional Impact and Mechanisms
Disease COVID-19    
Immune -
Target Gene -
Clinical and Epidemiological Correlations
Clinical Information Y
Treatment -
Location Mexico
Literature Information
PMID 37260697
Title Molecular transition of SARS-CoV-2 from critical patients during the first year of the COVID-19 pandemic in Mexico City
Author De La Cruz-Montoya AH,Diaz Velasquez CE,Martinez-Gregorio H,Ruiz-De La Cruz M,Bustos-Arriaga J,Castro-Jimenez TK,Olguin-Hernandez JE,Rodriguez-Sosa M,Terrazas-Valdes LI,Jimenez-Alvarez LA,Regino-Zamarripa NE,Ramirez-Martinez G,Cruz-Lagunas A,Peralta-Arrieta I,Armas-Lopez L,Contreras-Garza BM,Palma-Cortes G,Cabello-Gutierrez C,Baez-Saldana R,Zuniga J,Avila-Moreno F,Vaca-Paniagua F
Journal Frontiers in cellular and infection microbiology
Journal Info 2023 May 16;13:1155938
Abstract BACKGROUND: The SARS-CoV-2 virus has caused unprecedented mortality since its emergence in late 2019. The continuous evolution of the viral genome through the concerted action of mutational forces has produced distinct variants that became dominant, challenging human immunity and vaccine development. AIM AND METHODS: In this work, through an integrative genomic approach, we describe the molecular transition of SARS-CoV-2 by analyzing the viral whole genome sequences from 50 critical COVID-19 patients recruited during the first year of the pandemic in Mexico City. RESULTS: Our results revealed differential levels of the evolutionary forces across the genome and specific mutational processes that have shaped the first two epidemiological waves of the pandemic in Mexico. Through phylogenetic analyses, we observed a genomic transition in the circulating SARS-CoV-2 genomes from several lineages prevalent in the first wave to a dominance of the B.1.1.519 variant (defined by T478K, P681H, and T732A mutations in the spike protein) in the second wave. CONCLUSION: This work contributes to a better understanding of the evolutionary dynamics and selective pressures that act at the genomic level, the prediction of more accurate variants of clinical significance, and a better comprehension of the molecular mechanisms driving the evolution of SARS-CoV-2 to improve vaccine and drug development.
Sequence Data PRJNA967733
Mutation Information
Note
Basic Characteristics of Mutations
  • Mutation Site: The specific location in a gene or protein sequence where a change occurs.
  • Mutation Level: The level at which a mutation occurs, including the nucleotide or amino acid level.
  • Mutation Type: The nature of the mutation, such as missense mutation, nonsense mutation, synonymous mutation, etc.
  • Gene/Protein/Region: Refers to the specific region of the virus where the mutation occurs. Including viral genes, viral proteins, or a specific viral genome region. If the article does not specifically indicate the relationship between the mutation and its correspondence, the main
  • Gene/Protein/Region studied in the article is marked.
  • Genotype/Subtype: Refers to the viral genotype or subtype where the mutation occurs. If the article does not specifically indicate the relationship between the mutation and its correspondence, the main Genotype/Subtype studied in the article is marked.
  • Viral Reference: Refers to the standard virus strain used to compare and analyze viral sequences.
Functional Impact and Mechanisms
  • Disease: An abnormal physiological state with specific symptoms and signs caused by viral infection.
  • Immune: The article focuses on the study of mutations and immune.
  • Target Gene: Host genes that viral mutations may affect.
Clinical and Epidemiological Correlations
  • Clinical Information: The study is a clinical or epidemiological study and provides basic information about the population.
  • Treatment: The study mentioned a certain treatment method, such as drug resistance caused by mutations. If the study does not specifically indicate the relationship between mutations and their correspondence treatment, the main treatment studied in the article is marked.
  • Location: The source of the research data.
Literature Information
  • Sequence Data: The study provides the data accession number.