CHIKV Mutation Detail Information

Virus Mutation CHIKV Mutation V264A


Basic Characteristics of Mutations
Mutation Site V264A
Mutation Site Sentence This strain possessed E1-K211E, E2-V264A, and E1-I317V mutations.
Mutation Level Amino acid level
Mutation Type Nonsynonymous substitution
Gene/Protein/Region E2
Standardized Encoding Gene E2
Genotype/Subtype -
Viral Reference KY057363
Functional Impact and Mechanisms
Disease Chikungunya Fever    
Immune -
Target Gene -
Clinical and Epidemiological Correlations
Clinical Information Y
Treatment -
Location -
Literature Information
PMID 39469502
Title Genetic characterization and phylogenetic analysis of Chikungunya Virus: A case from Jeddah during the COVID-19 Pandemic
Author Alguridi HI,Zaki EA,Hapuarachchi HC,Almalki SA,Alzahrani AA,Alsalem WS,Alzahrani FA,Altayb HN
Journal IDCases
Journal Info 2024 Oct 11;38:e02087
Abstract Chikungunya fever is an arboviral disease caused by the Chikungunya virus (CHIKV), which is classified into three genotypes, namely Asian, West African, and East/Central/South African (ECSA). Due to the frequency and severity of CHIKV outbreaks, it is crucial to genetically characterize the virus, especially in non-endemic regions. This report describes a case and genome characterization of CHIKV from a case that was detected in Jeddah (in 2021) during the COVID-19 pandemic. CHIKV was identified in a 32-year-old male patient in Jeddah, originally from India, who presented with fever, myalgia, malaise, and fatigue and was initially suspected of having dengue. The patient had no history of travel in the fortnight prior to his presentation. Treatment included paracetamol, saline, and vitamin C, which is important for the host immune response and detoxification of viral products. The genome of CHIKV was sequenced using various techniques and bioinformatics tools. Amino acid mutations were studied. Phylogenetic analysis showed that the CHIKV strain detected in 2021 was genetically distinct from those reported in 2018. The 2021 virus shared ancestry with CHIKV strains reported in India. This strain possessed E1-K211E, E2-V264A, and E1-I317V mutations. Novel substitutions were identified. The CHIKV re-emergence in 2021 in Jeddah belonged to the Indian subcontinent/Southeast Asia clade of ECSA. More molecular epidemiological information is needed to better understand and evaluate the prevalence of CHIKV in Saudi Arabia.
Sequence Data OR626603
Mutation Information
Note
Basic Characteristics of Mutations
  • Mutation Site: The specific location in a gene or protein sequence where a change occurs.
  • Mutation Level: The level at which a mutation occurs, including the nucleotide or amino acid level.
  • Mutation Type: The nature of the mutation, such as missense mutation, nonsense mutation, synonymous mutation, etc.
  • Gene/Protein/Region: Refers to the specific region of the virus where the mutation occurs. Including viral genes, viral proteins, or a specific viral genome region. If the article does not specifically indicate the relationship between the mutation and its correspondence, the main
  • Gene/Protein/Region studied in the article is marked.
  • Genotype/Subtype: Refers to the viral genotype or subtype where the mutation occurs. If the article does not specifically indicate the relationship between the mutation and its correspondence, the main Genotype/Subtype studied in the article is marked.
  • Viral Reference: Refers to the standard virus strain used to compare and analyze viral sequences.
Functional Impact and Mechanisms
  • Disease: An abnormal physiological state with specific symptoms and signs caused by viral infection.
  • Immune: The article focuses on the study of mutations and immune.
  • Target Gene: Host genes that viral mutations may affect.
Clinical and Epidemiological Correlations
  • Clinical Information: The study is a clinical or epidemiological study and provides basic information about the population.
  • Treatment: The study mentioned a certain treatment method, such as drug resistance caused by mutations. If the study does not specifically indicate the relationship between mutations and their correspondence treatment, the main treatment studied in the article is marked.
  • Location: The source of the research data.
Literature Information
  • Sequence Data: The study provides the data accession number.