SARS-CoV-2 Mutation Detail Information

Virus Mutation SARS-CoV-2 Mutation W152R


Basic Characteristics of Mutations
Mutation Site W152R
Mutation Site Sentence As for BA.2.75, there are more distinct substitutions, including K147E, W152R, F157L, I210V, G257S, G339H, G446S, and N460K (Supplementary Fig. 1). 
Mutation Level Amino acid level
Mutation Type Nonsynonymous substitution
Gene/Protein/Region S
Standardized Encoding Gene S  
Genotype/Subtype BA.2.75
Viral Reference -
Functional Impact and Mechanisms
Disease Cell line    
Immune -
Target Gene -
Clinical and Epidemiological Correlations
Clinical Information -
Treatment -
Location -
Literature Information
PMID 37479708
Title Structural basis for receptor binding and broader interspecies receptor recognition of currently circulating Omicron sub-variants
Author Zhao Z,Xie Y,Bai B,Luo C,Zhou J,Li W,Meng Y,Li L,Li D,Li X,Li X,Wang X,Sun J,Xu Z,Sun Y,Zhang W,Fan Z,Zhao X,Wu L,Ma J,Li OY,Shang G,Chai Y,Liu K,Wang P,Gao GF,Qi J
Journal Nature communications
Journal Info 2023 Jul 21;14(1):4405
Abstract Multiple SARS-CoV-2 Omicron sub-variants, such as BA.2, BA.2.12.1, BA.4, and BA.5, emerge one after another. BA.5 has become the dominant strain worldwide. Additionally, BA.2.75 is significantly increasing in some countries. Exploring their receptor binding and interspecies transmission risk is urgently needed. Herein, we examine the binding capacities of human and other 28 animal ACE2 orthologs covering nine orders towards S proteins of these sub-variants. The binding affinities between hACE2 and these sub-variants remain in the range as that of previous variants of concerns (VOCs) or interests (VOIs). Notably, R493Q reverse mutation enhances the bindings towards ACE2s from humans and many animals closely related to human life, suggesting an increased risk of cross-species transmission. Structures of S/hACE2 or RBD/hACE2 complexes for these sub-variants and BA.2 S binding to ACE2 of mouse, rat or golden hamster are determined to reveal the molecular basis for receptor binding and broader interspecies recognition.
Sequence Data "EMD-33870;EMD-33841;EMD-34409;EMD-34138;EMD-34217;EMD-34120;EMD-34494;EMD-34498;EMD-34499;EMD-34509;EMD-34510;EMD-34506;PDB:7YJ3,7YHW,8H06,7YVU,8GRY,7YV8,8H5C;NMDCS0000020-NMDCS0000026"
Mutation Information
Note
Basic Characteristics of Mutations
  • Mutation Site: The specific location in a gene or protein sequence where a change occurs.
  • Mutation Level: The level at which a mutation occurs, including the nucleotide or amino acid level.
  • Mutation Type: The nature of the mutation, such as missense mutation, nonsense mutation, synonymous mutation, etc.
  • Gene/Protein/Region: Refers to the specific region of the virus where the mutation occurs. Including viral genes, viral proteins, or a specific viral genome region. If the article does not specifically indicate the relationship between the mutation and its correspondence, the main
  • Gene/Protein/Region studied in the article is marked.
  • Genotype/Subtype: Refers to the viral genotype or subtype where the mutation occurs. If the article does not specifically indicate the relationship between the mutation and its correspondence, the main Genotype/Subtype studied in the article is marked.
  • Viral Reference: Refers to the standard virus strain used to compare and analyze viral sequences.
Functional Impact and Mechanisms
  • Disease: An abnormal physiological state with specific symptoms and signs caused by viral infection.
  • Immune: The article focuses on the study of mutations and immune.
  • Target Gene: Host genes that viral mutations may affect.
Clinical and Epidemiological Correlations
  • Clinical Information: The study is a clinical or epidemiological study and provides basic information about the population.
  • Treatment: The study mentioned a certain treatment method, such as drug resistance caused by mutations. If the study does not specifically indicate the relationship between mutations and their correspondence treatment, the main treatment studied in the article is marked.
  • Location: The source of the research data.
Literature Information
  • Sequence Data: The study provides the data accession number.