SARS-CoV-2 Mutation Detail Information

Virus Mutation SARS-CoV-2 Mutation Y91A


Basic Characteristics of Mutations
Mutation Site Y91A
Mutation Site Sentence Mutagenesis of the LCDR3 similarly resulted in notable reduction in binding observed for Tyr91Ala and Arg96Ala substitutions, although neither of these residues directly contacted the RBD.
Mutation Level Amino acid level
Mutation Type Nonsynonymous substitution
Gene/Protein/Region
Standardized Encoding Gene
Genotype/Subtype B.1.1.7;B.1.351;P.1;B.1.429;B.1.526;B.1.617.1;B.1.617.2
Viral Reference KT444582;AY278554;AY278741;AY515512;AY525636;KC881005;KC881006;KF367457;MK211376;MN908947;MN996532;MG772933;MG772934;MK211374;DQ412042;DQ648856;MK211378;DQ022305;DQ412043;DQ648857;DQ071615;MK211375;MK211377
Functional Impact and Mechanisms
Disease Cell line    
Immune -
Target Gene -
Clinical and Epidemiological Correlations
Clinical Information -
Treatment -
Location -
Literature Information
PMID 34726473
Title A broadly cross-reactive antibody neutralizes and protects against sarbecovirus challenge in mice
Author Martinez DR,Schafer A,Gobeil S,Li D,De la Cruz G,Parks R,Lu X,Barr M,Stalls V,Janowska K,Beaudoin E,Manne K,Mansouri K,Edwards RJ,Cronin K,Yount B,Anasti K,Montgomery SA,Tang J,Golding H,Shen S,Zhou T,Kwong PD,Graham BS,Mascola JR,Montefiori DC,Alam SM,Sempowski G,Sempowski GD,Khurana S,Wiehe K,Saunders KO,Acharya P,Haynes BF,Baric RS
Journal Science translational medicine
Journal Info 2022 Jan 26;14(629):eabj7125
Abstract Severe acute respiratory syndrome coronaviruses 1 (SARS-CoV) and 2 (SARS-CoV-2), including SARS-CoV-2 variants of concern, can cause deadly infections. The mortality associated with sarbecovirus infection underscores the importance of developing broadly effective countermeasures against them, which could be key in the prevention and mitigation of current and future zoonotic events. Here, we demonstrate the neutralization of SARS-CoV; bat coronaviruses WIV-1 and RsSHC014; and SARS-CoV-2 variants D614G, B.1.1.7, B.1.351, P.1, B.1.429, B.1.526, B.1.617.1, and B.1.617.2 by a receptor binding domain (RBD)-specific human antibody, DH1047. Prophylactic and therapeutic treatment with DH1047 was protective against SARS-CoV, WIV-1, RsSHC014, and SARS-CoV-2 B.1.351 infection in mice. Binding and structural analysis showed high affinity binding of DH1047 to an epitope that is highly conserved among sarbecoviruses. Thus, DH1047 is a broadly protective antibody that can prevent infection and mitigate outbreaks caused by SARS-related strains and SARS-CoV-2 variants. Our results also suggest that the conserved RBD epitope bound by DH1047 is a rational target for a universal sarbecovirus vaccine.
Sequence Data -
Mutation Information
Note
Basic Characteristics of Mutations
  • Mutation Site: The specific location in a gene or protein sequence where a change occurs.
  • Mutation Level: The level at which a mutation occurs, including the nucleotide or amino acid level.
  • Mutation Type: The nature of the mutation, such as missense mutation, nonsense mutation, synonymous mutation, etc.
  • Gene/Protein/Region: Refers to the specific region of the virus where the mutation occurs. Including viral genes, viral proteins, or a specific viral genome region. If the article does not specifically indicate the relationship between the mutation and its correspondence, the main
  • Gene/Protein/Region studied in the article is marked.
  • Genotype/Subtype: Refers to the viral genotype or subtype where the mutation occurs. If the article does not specifically indicate the relationship between the mutation and its correspondence, the main Genotype/Subtype studied in the article is marked.
  • Viral Reference: Refers to the standard virus strain used to compare and analyze viral sequences.
Functional Impact and Mechanisms
  • Disease: An abnormal physiological state with specific symptoms and signs caused by viral infection.
  • Immune: The article focuses on the study of mutations and immune.
  • Target Gene: Host genes that viral mutations may affect.
Clinical and Epidemiological Correlations
  • Clinical Information: The study is a clinical or epidemiological study and provides basic information about the population.
  • Treatment: The study mentioned a certain treatment method, such as drug resistance caused by mutations. If the study does not specifically indicate the relationship between mutations and their correspondence treatment, the main treatment studied in the article is marked.
  • Location: The source of the research data.
Literature Information
  • Sequence Data: The study provides the data accession number.