Gene Name	ATF4
Gene ID	468
Gene Full Name	activating transcription factor 4
Gene Alias	CREB-2|CREB2|TAXREB67|TXREB
Transcripts	ENSG00000128272
Virus	ZIKV
Gene Type	protein-coding
HPA Location Info	Nucleoplasm;
Membrane Info	Predicted intracellular proteins, Transcription factors
Uniport_ID	P18848
HGNC ID	HGNC:786
OMIM ID	604064
Summary	This gene encodes a transcription factor that was originally identified as a widely expressed mammalian DNA binding protein that could bind a tax-responsive enhancer element in the LTR of HTLV-1. The encoded protein was also isolated and characterized as the cAMP-response element binding protein 2 (CREB-2). The protein encoded by this gene belongs to a family of DNA-binding proteins that includes the AP-1 family of transcription factors, cAMP-response element binding proteins (CREBs) and CREB-like proteins. These transcription factors share a leucine zipper region that is involved in protein-protein interactions, located C-terminal to a stretch of basic amino acids that functions as a DNA binding domain. Two alternative transcripts encoding the same protein have been described. Two pseudogenes are located on the X chromosome at q28 in a region containing a large inverted duplication. [provided by RefSeq, Sep 2011]

Mutation Table: if previous studies reported that target gene was related to virus gene/region/protein, the information in this literature was listed in this section

ID	PMID	Mutation	Gene/Protein/Region	Encoding Gene/Protein	Disease	Description	Detail
1	40291117	N154A	E	envelope	Cell line	D R T	View
2	40291117	N154D	E	envelope	Cell line	D R I T	View
3	40291117	V153D	E	envelope	Cell line	D R I T	View

Data ID	Experiment type	Sample number	Platform
GSE198542	RNA-seq	12	Illumina NextSeq 500 (Homo sapiens)
GSE176428	RNA-seq	8	Illumina MiSeq (Homo sapiens)
GSE78711	RNA-seq	8	Illumina MiSeq (Homo sapiens);Illumina NextSeq 500 (Homo sapiens)
GSE178621	RNA-seq	28	Illumina NovaSeq 6000 (Homo sapiens)
C   GSE161783	Chip-seq;RNA-seq;csRNA-seq	51	Illumina NextSeq 500 (Homo sapiens);Illumina HiSeq 4000 (Homo sapiens);Illumina NovaSeq 6000 (Homo sapiens)
GSE105884	RNA-seq	60	Illumina HiSeq 2500 (Homo sapiens)
GSE209698	RNA-seq	16	Illumina NextSeq 500 (Homo sapiens)
GSE123835	RNA-seq	6	Illumina HiSeq 2500 (Homo sapiens)
GSE160201	RNA-seq	16	Illumina NextSeq 500 (Homo sapiens)

• Genome binding/occupancy profiling

When the gene can detect a peak in the dataset, a peak plot will be displayed.

> Dataset: GSE161783 - ATF4 peak across samples

Peak Plot