Virus Dataset Detail

> Detail information for each sample

Dataset Information
Accession GSE198542
Status 2022/10/31
Title Type I interferons govern Zika virus resistance of human macrophages and microglia
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary The role of the human type I interferon (IFN-I) system in restricting Zika virus (ZIKV) is uncertain. Here, genetic and pharmacological ablation of IFN-I signalling enhanced ZIKV replication and cytopathicity in macrophages and microglia, key cells in ZIKV transmission and pathogenesis. Thus, despite the extensive IFN-I countermeasures employed by ZIKV, IFN-I dictates the outcome of infection in macrophages. Therapeutic manipulation of the IFN-I system may bring clinical benefit in ZIKV.
Samples
GSM ID Sample info Characteristics Description
GSM5951877 1_17_WT_uninfected_MOCK ifnar2:positive; zikv:MOCK; extraction date:20191129 -
GSM5951878 2_18_WT_infected_ZIKV ifnar2:positive; zikv:ZIKV; extraction date:20191129 -
GSM5951879 3_19_MUT_uninfected_MOCK ifnar2:negative; zikv:MOCK; extraction date:20191129 -
GSM5951880 4_20_MUT_infected_ZIKV ifnar2:negative; zikv:ZIKV; extraction date:20191129 -
GSM5951881 5_25_WT_uninfected_MOCK ifnar2:positive; zikv:MOCK; extraction date:20191129 -
GSM5951882 6_26_WT_infected_ZIKV ifnar2:positive; zikv:ZIKV; extraction date:20191129 -
GSM5951883 7_27_MUT_uninfected_MOCK ifnar2:negative; zikv:MOCK; extraction date:20191129 -
GSM5951884 8_28_MUT_infected_ZIKV ifnar2:negative; zikv:ZIKV; extraction date:20191129 -
GSM5951885 9_29_WT_uninfected_MOCK ifnar2:positive; zikv:MOCK; extraction date:20191217 -
GSM5951886 10_30_WT_infected_ZIKV ifnar2:positive; zikv:ZIKV; extraction date:20191217 -
GSM5951887 11_31_MUT_uninfected_MOCK ifnar2:negative; zikv:MOCK; extraction date:20191217 -
GSM5951888 12_32_MUT_infected_ZIKV ifnar2:negative; zikv:ZIKV; extraction date:20191217 -
Platform GPL18573  : Illumina NextSeq 500 (Homo sapiens)
Literature 36439115  
Download Download xCell Data  Download Expression Analysis Data  
xCell Plot
* p<0.05 ** p<0.01